A Brief Review on 3D Bioprinted Skin Substitutes

Fayyazbakhsh, Fateme; Leu, Ming-Chuan

doi:10.1016/j.promfg.2020.05.115

Cited by 25 publications

(22 citation statements)

References 46 publications

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“…The hierarchical design of fabricated MEW mPCL, assimilated the J‐shaped strain stiffening, anisotropic behavior of natural skin tissue, and created a cellular environment similar to native stem cell niche that enhanced human gingival tissue multipotent MSC (hGMSC) attachment and proliferation. [ 167 ] In another study, Li et al. developed a novel transparent in situ forming hydrogels dressing with multiple properties including moist‐retaining, self‐healing, and bioadhesiveness to augment the wound healing process.…”

Section: Bioinspired Active Dressingsmentioning

confidence: 99%

“…These type of thin‐film skin bandages can be employed for multiple purposes, including analyzing the drug abuse, athletic performance, or disease diagnosis at the early stages. [ 167–169 ] The utilized electrodes and biosensors in these sweat analyzing skin bandages are capable of detecting a broad class of biomarkers including ions (Na+, Cl−, K+, NH4+), molecules (cortisol, urea, lactate, glucose), or small proteins and peptides. [ 170 ] Koh et al.…”

Section: Soft Electronic Materials In Fabricating Smart Wound Dressingsmentioning

confidence: 99%

“…Recently, 3D bioprinting technology has received significant attention as a new area of research in medicine. Diverse applications of this technology in the fabrication of native tissue mimicking structures or biosensing substrates have promised a bright future for the treatment of different types of diseases, [ 167,197 ] including skin burns, and chronic wounds. [ 198 ] Thanks to the superiority of bioprinting technology in the precise deposition of cells and biomaterials in a 3D orientation fashion, clinical applications of this approach in fabricating appropriate wound dressings promise an auspicious skin regeneration alternative for large skin size defects compared to previous conventional approaches.…”

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

“…Distinguished properties of electrospun nanofiber‐based wound dressings, including ease of fabrication, degraded without causing any substantial immune‐response, have turned these constructions into a favorable substance for direct delivery of therapeutic molecules to the wound site. [ 167 ] Jiang et al. fabricated a nanofiber‐based wound dressing using gelatin/polycaprolactone conjugated with dopamine to eliminate the postsurgical defect of sutures after surgical incision.…”

Section: Evolutionary Trend Of Wound Dressingsmentioning

confidence: 99%

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Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

317

219

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The universal increase in the number of patients with nonhealing skin wounds imposes a huge social and economic burden on the patients and healthcare systems. Although, the application of traditional wound dressings contributes to an effective wound healing outcome, yet, the complexity of the healing process remains a major health challenge. Recent advances in materials and fabrication technologies have led to the fabrication of dressings that provide proper conditions for effective wound healing. The 3D‐printed wound dressings, biomolecule‐loaded dressings, as well as smart and flexible bandages are among the recent alternatives that have been developed to accelerate wound healing. Additionally, the new generation of wound dressings contains a variety of microelectronic sensors for real‐time monitoring of the wound environment and is able to apply required actions to support the healing progress. Moreover, advances in manufacturing flexible microelectronic sensors enable the development of the next generation of wound dressing substrates, known as electronic skin, for real‐time monitoring of the whole physiochemical markers in the wound environment in a single platform. The current study reviews the importance of smart wound dressings as an emerging strategy for wound care management and highlights different types of smart dressings for promoting the wound healing process.

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Section: Bioinspired Active Dressingsmentioning

confidence: 99%

Section: Soft Electronic Materials In Fabricating Smart Wound Dressingsmentioning

confidence: 99%

Section: D Printing Technologies For the Development Of Wound Dressingsmentioning

confidence: 99%

Section: Evolutionary Trend Of Wound Dressingsmentioning

confidence: 99%

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Wound Healing: From Passive to Smart Dressings

Farahani

Shafiee

2021

Adv Healthcare Materials

317

219

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“…There are excellent reviews that cover 3D printing and its applications on the skin, as transdermal drug delivery [21] and bioprinting [22][23][24]. However, to the best of our knowledge, none of them were dedicated to discussing the association of 3D printing and pharmaceutical topical skin products for drug delivery and dressings.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

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3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

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