A brief history of the DNA repair field

Friedberg, Errol C.

doi:10.1038/cr.2007.113

Cited by 95 publications

(59 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At least six distinct DNA repair pathways have been described. A detailed discussion of individual pathways is beyond the scope of this chapter as several recent excellent reviews on DNA repair are available [1][2][3][4][5][6]. Briefly, direct repair is involved in the repair of alkylated bases (such as O 6 methyl guanine) by MGMT (O 6 methyl guanine DNA methyl transferases [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

Mohan¹,

Madhusudan²

2013

New Research Directions in DNA Repair

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

Mohan¹,

Madhusudan²

2013

New Research Directions in DNA Repair

View full text Add to dashboard Cite

“…The response of marine bacteria to UVA irradiation is considered important because approximately 95 % of UV radiation is UVA (320-400 nm). On the other hand, bacteria are also exposed to UVC (254 nm) radiation used as a disinfection method to kill bacteria and prevent food poisoning in humans [3].…”

Section: Introductionmentioning

confidence: 99%

“…to sense and respond effectively to changes in the environment is crucial for their survival [2]. Bacteria in nature have cellular physiological systems to protect cells from various environmental stresses such as ultraviolet irradiation [3]. Marine bacteria, such as Vibrio alginolyticus and V. parahaemolyticus, are exposed to solar UV radiation daily.…”

Section: Introductionmentioning

confidence: 99%

Identification of Outer Membrane Proteins Altered in Response to UVC-Radiation in Vibrio parahaemolyticus and Vibrio alginolyticus

et al. 2012

View full text Add to dashboard Cite

Vibrio parahaemolyticus and V. alginolyticus, marine foodborne pathogens, were treated with UVCradiation (240 J/m 2 ) to evaluate alterations in their outer membrane protein profiles. Outer membrane protein patterns of UVC-irradiated bacteria were found altered when analyzed by sodium dodecyl sulphate polyacrylamide gel electrophoresis. Altered proteins were identified by mass spectrometry (MS and MS/MS) and analysis revealed that OmpW, OmpA, Long-chain fatty acid transport protein, Outer membrane receptor protein, Putative uncharacterized protein VP0167, Maltoporin (lamB), Polar flagellin B/D, Agglutination protein Peptidoglycan-associated lipoprotein and MltA-interacting protein MipA were appeared, thereby they can be considered as UVC-stress proteins in some vibrios. In addition, expression of OmpK decreased to nondetectable level. Furthermore, we observed a decrease or an increase in the expression level of other outer membrane proteins.

show abstract

“…In addition, the genomic DNA is probably subject to various types of damage caused by a range of endogenous and environmental factors which may cause single-or double-strand breaks, nucleotide modifications, abasic sites, bulky adducts, and mismatches (14). Virtually all bacteria have evolved more or less sophisticated DNA repair mechanisms to limit the detrimental effects of DNA damage and to maintain the structure and genetic integrity of their DNA (16). The importance of DNA repair for the survival and genetic diversity of C. jejuni, however, is still largely unknown.…”

mentioning

confidence: 99%

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

et al. 2009

View full text Add to dashboard Cite

The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C. jejuni NCTC 11168 suggests the presence of genes involved in methyl-directed mismatch repair (MMR), nucleotide excision repair, base excision repair (BER), and recombinational repair. To assess the functionality of these putative repair mechanisms in C. jejuni, mutS, uvrB, ung, and recA knockout mutants were constructed and analyzed for their ability to repair spontaneous point mutations, UV irradiation-induced DNA damage, and nicked DNA. Inactivation of the different putative DNA repair genes did not alter the spontaneous mutation frequency. Disruption of the UvrB and RecA orthologues, but not the putative MutS or Ung proteins, resulted in a significant reduction in viability after exposure to UV irradiation. Assays performed with uracil-containing plasmid DNA showed that the putative uracil-DNA glycosylase (Ung) protein, important for initiation of the BER pathway, is also functional in C. jejuni. Inactivation of recA also resulted in a loss of natural transformation. Overall, the data indicate that C. jejuni has multiple functional DNA repair systems that may protect against DNA damage and limit the generation of genetic diversity. On the other hand, the apparent absence of a functional MMR pathway may enhance the frequency of on-and-off switching of phase variable genes typical for C. jejuni and may contribute to the genetic heterogeneity of the C. jejuni population.

show abstract

A brief history of the DNA repair field

Cited by 95 publications

References 18 publications

DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

DNA Base Excision Repair: Evolving Biomarkers for Personalized Therapies in Cancer

Identification of Outer Membrane Proteins Altered in Response to UVC-Radiation in Vibrio parahaemolyticus and Vibrio alginolyticus

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni

Contact Info

Product

Resources

About