A botulinum neurotoxin-like function ofPotentilla chinensisextract that inhibits neuronal SNARE complex formation, membrane fusion, neuroexocytosis, and muscle contraction

Potentilla and Rubus medicinal plants

“…An ethanolic extract from R. coreanus showed fatigue-alleviating effect on mice (Lee et al, 2011b). The extract of P. chinensis (Chinese cinquefoil) flower inhibited neurotransmitter release from neuronal PC12 cells by approximately 90% at a concentration of 10 mg/ml (Jung et al, 2012). The extract paralyzed muscle as efficiently as botulinum neurotoxins, suggesting its potential versatility in cosmetics and therapeutics.…”