“…Experimental results showed that only H 2 O 2 induced a strong fluorescence enhancement, while other ROS generating agents, KO 2 , NaOCl, NaOtBu, ONOO – , TBHP, TBAB, TBAF, ascorbic acid, BSA, glutamic acid, proline, leucine, and tryptophan, showed insignificant changes (Figure B). In some cases, peroxynitrite (ONOO – ) reacts with the boronate ester group and transform to other fluorescent products. , But, some reports also show that ONOO – does not have much significant reaction with the boronate ester group. , Our derivative VBD also not significantly react with ONOO – . The tremendous selectivity of our probe toward H 2 O 2 is due to the H 2 O 2 specific boronate deprotection reaction.…”