A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids

Devarajan, Sriraman; Chatterjee, Biprabuddha; Urata, Hidenori; Zhang, Bo; Ali, Amanat; Singh, Ravinder; Sambandam, G.

doi:10.1016/j.amjmed.2016.02.044

Cited by 37 publications

(30 citation statements)

References 45 publications

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“…Our results do not correspond with studies showing significantly decreased levels of TGs [14,15,17,25]. Kuriyan and colleagues used RBO for daily cooking so that it did not change the proportion of daily fat intake.…”

Section: Discussioncontrasting

confidence: 99%

“…Changes in blood glucose levels upon RBO administration in the present study were not significantly different from those recorded in other studies. In research conducted by Devarajan and colleagues using a mixture of RBO with sesame seeds in a large study for 8 w, changes in blood glucose levels showed a significant change (p<0.001) [17].…”

Section: Discussionmentioning

confidence: 93%

“…Devarajan and co-workers found a significant increase in HDL-C levels at 8 w in 300 newly diagnosed DM patients given a mixture of EVOO and sesame seeds [17]. Previous studies on EVOO showed no significant changes in olive oil [15].…”

Section: Discussionmentioning

confidence: 96%

“…Studies conducted by the research teams of Rivellese [14], Carnevale [15], Lai [16], Devarajan [17], and Violi [18] have shown that RBO and EVOO can reduce blood sugar levels and control levels of cholesterol and TGs in T2DM patients. However, it is not known if RBO or EVOO is more effective in daily use, a question that we attempted to answer in the present study.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Extra Virgin Olive Oil Versus Rice Bran Oil on Glycemic Control in Patients With Type-2 Diabetes Mellitus

et al. 2019

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Objective: The purpose of this study was to determine the effect of extra virgin olive oil (EVOO) and rice bran oil (RBO) on glycemic control and lipid profiles in patients with type-2 diabetes mellitus (T2DM). Methods: Ten patients with T2DM received 15 ml/day of EVOO or RBO. Levels of fasting blood glucose (FBG), postprandial blood glucose (PBG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TGs) were measured. RBO or EVOO was administered for 4 consecutive weeks. During a 2-week interval, the treatment was not administered. After this washout period, a crossover design was implemented by exchanging EVOO supplementation with RBO supplementation and vice versa for 4 consecutive weeks. Results: Changes in levels of FBG, PBG, TC, LDL-C, and TGs were not significantly different in the two groups. However, significantly decreased the levels of HDL-C were observed in both groups. Conclusion: RBO and EVOO had no significant influence on levels of FBG or PBG.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Effects of Extra Virgin Olive Oil Versus Rice Bran Oil on Glycemic Control in Patients With Type-2 Diabetes Mellitus

et al. 2019

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“…Devarajan et al . () reported that HDL‐c levels increased significantly in hypertensive patients treated with sesame oil.…”

Section: Discussionmentioning

confidence: 97%

Effect of testosterone supplementation on nitroso‐redox imbalance, cardiac metabolism markers, and S100 proteins expression in the heart of castrated male rats

et al. 2017

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The aim of this study was to investigate the effects of castration and testosterone supplementation on nitroso-redox status, cardiac metabolism markers, and S100 proteins expression in the heart of male rats. 50 male Wistar rats were randomized into five groups with ten animals each: group 1: control intact (CON); group 2: sham operated (Sh-O); group 3: sesame oil-treated rats (S-oil); group 4: gonadoectomized (GDX); and group 5: gonadoectomized rats treated with testosterone (GDX-T) for 8 weeks. Our results showed myofibrillar weaving, apoptosis, inflammation, and fibrosis (as reflected by increased activity of MMP 9 and MMP 2) in the heart of gonadoectomized rats. Testosterone supplementation restored the normal structure of the heart. In addition, a state of nitroso-redox imbalance was observed in the heart of castrated rats with increased NO (425.1 ± 322.8 vs. 208 ± 67.06, p ˂ 0.05) and MDA (33.18 ± 9.45 vs. 22.04 ± 7.13, p ˂ 0.05) and decreased GSH levels (0.71 ± 0.13 vs. 1.09 ± 0.19, p = 0.001). Testosterone treatment leads to a re-establish of only NO levels (425.1 ± 322.8 vs. 210.4 ± 114.3, p > 0.05). Markers of cardiac metabolism showed an enhancement of LDH activity (12725 ± 4604 vs. 5381 ± 3122, p ˂ 0.05) in the heart of castrated rats. This was inversed by testosterone replacement (12725 ± 4604 vs. 5781 ± 5187, p ˂ 0.05). Furthermore, castration induced heart's accumulation of triglycerides (37.24 ± 6.17 vs. 27.88 ± 6.47, p ˂ 0.05) and total cholesterol (61.44 ± 3.59 vs. 54.11 ± 7.55, p ˂ 0.05), which were significantly reduced by testosterone supplementation (29.03 ± 2.47 vs. 37.24 ± 6.17, p ˂ 0.05) and (47.9 ± 4.15 vs. 61.44 ± 3.59, p ˂ 0.001). Cardiomyocytes of castrated rats showed a decreased immunoexpression of S100 proteins compared to control animals. A restoration of S100 proteins immunostaining in cardiomyocyte cytoplasm was observed after testosterone supplementation. These findings confirm the deleterious effects of testosterone deficiency on cardiac function and highlight the involvement of nitric oxide, metalloproteinases 2 and 9, and S100 proteins.

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Canola oil compared with sesame and sesame‐canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three‐way randomized triple‐blind cross‐over trial

Raeisi‐Dehkordi

Amiri

Zimorovat

et al. 2020

Diabetes Metabolism Res

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Background This study aimed to compare the effects of sesame (SO), canola (CO), and sesame‐canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 diabetes. Methods In this randomized, triple‐blind, three‐way, cross‐over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2‐IR), beta‐cell function (HOMA2‐%B), insulin sensitivity (HOMA2‐%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods. Results Ninety‐two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2‐%S (p < 0.05). SO and SCO led to favourable changes in HOMA2‐IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2‐%B (p < 0.05). The sex‐stratified analysis revealed that FSI and HOMA2‐IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma‐glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058). Conclusions SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).

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A Blend of Sesame and Rice Bran Oils Lowers Hyperglycemia and Improves the Lipids

Abstract: A novel blend of 20% cold-pressed unrefined sesame oil and 80% physically refined rice bran oil as cooking oil, lowered hyperglycemia and improved the lipid profile in type 2 diabetes mellitus patients.

Cited by 37 publications

References 45 publications

Effects of Extra Virgin Olive Oil Versus Rice Bran Oil on Glycemic Control in Patients With Type-2 Diabetes Mellitus

Effects of Extra Virgin Olive Oil Versus Rice Bran Oil on Glycemic Control in Patients With Type-2 Diabetes Mellitus

Effect of testosterone supplementation on nitroso‐redox imbalance, cardiac metabolism markers, and S100 proteins expression in the heart of castrated male rats

Canola oil compared with sesame and sesame‐canola oil on glycaemic control and liver function in patients with type 2 diabetes: A three‐way randomized triple‐blind cross‐over trial

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