A blend of benzoic acid and essential oil compounds as an alternative to antibiotic growth promoters in broiler diets

Aristimunha, P. C.; Rosa, Alexandre Pires; Boemo, Lenise Schroder; Garcez, Dino César Pereira; Rosa, Daniele Pozzebon da; Londero, A. T.; Scher, A.; Forgiarini, Juliana

doi:10.3382/japr/pfw015

Cited by 19 publications

(11 citation statements)

References 36 publications

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“…Generally, all parts contained tannins, polyphenols, flavonoids, saponin, terpenoids, steroids, and alkaloids, but tested negative for anthraquinone and glycoside. These findings concur with those obtained by Aristimunha et al (2016) and Ogbe and Affiku (2012) . Proportionately, the amounts determined from different plant parts in this study (see Table 2 ) compare well with those reported in other studies evaluating D. edulis phytochemical composition ( Ogboru, 2015 ; Ebana et al, 2016 ; Okolo et al, 2016 ; Oyetunji and Opeyemi, 2017 ).…”

Section: Discussionsupporting

confidence: 93%

Effect of feed supplementation of Dacryodes edulis parts’ powder as prebiotic on the growth traits, ceca microbiota and blood parameters of local chickens

Tangomo¹,

Keambou

Gicheha

et al. 2020

Translational Animal Science

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This study aimed at testing the efficacy and safety of Dacryodes edulis plant parts in diets fed to chicken. The plant has potential for use as a natural prebiotic to substitute the conventionally used antibiotic growth promoters in poultry production. Phytochemical analyses of the plant leaves, stem, and bark combination (stembark) and seed powders from the D. edulis were carried out. The powder from the three D. edulis plant parts were used as supplement in formulating six experimental diets tested in this study. The diets were TL0Ed (0.5% leaves powder), TL1Ed (1.0% leaves powder), TB0Ed (0.5% stembark powder), TB1Ed (1.0% stembark powder), TS0Ed (0.5% seeds powder), and TS1Ed (1.0% seeds powder). Besides, a positive (T+ positive control; 0.5-g oxytetracycline as recommended by the manufacturer) and a negative (T- negative control; having no commercial antibiotic and no plant supplement) diets were prepared for comparison purposes. The diets were fed to a total of 288 dual-purpose chicken for a period of 14 weeks. The chicken growth and body composition characteristics, blood chemistry, and microbiota count were collected and used as indicators of the plant parts efficacy and safety. The analysis of the D. edulis plant parts significantly differed (P ≤ 0.05) in their phytochemical contents. The initial body weight and feed conversion efficiency ratios were not significantly different (P ≥ 0.05) between and among treatment groups. However, significant differences (P ≤ 0.05) were detected in the feed intake and body weight gain at eighth week. Live weight at eighth week was significantly different (P ≤ 0.05) with its values ranging between 503.32 and 614.93 g for treatments TL1Ed and TNeg-, respectively. The dietary treatment of D. edulis leaves, stembark, and seed powder at the two inclusion levels significantly (P ≤ 0.05) decreased the colonies forming unit of Escherichia coli and Salmonella sp. as compared with negative control treatment in the eighth week phase. The level of glucose, total cholesterol, triglycerides, aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, and the packed cell volume did not differ significantly (P ≥ 0.05) between and among dietary D. edulis treatments. The findings from this research provide crucial information on the efficacy and safety of D. edulis plant parts. This is an important step in testing the potential of the plant in use as a prebiotic in chicken feeds production.

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Section: Discussionsupporting

confidence: 93%

Effect of feed supplementation of Dacryodes edulis parts’ powder as prebiotic on the growth traits, ceca microbiota and blood parameters of local chickens

Tangomo¹,

Keambou

Gicheha

et al. 2020

Translational Animal Science

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“…Data tabulated in the database were subjected to a mixed [30] 450 0-21 oregano EOs 0-500 Tiihonen et al [51] 720 0-42 Blend (thy, cin) 0-20 Amad et al [9] 528 0-42 Blend (thy, ane) 0-750 Amerah et al [59] 192 0-35 Blend (cin, thy) 0-100 Alp et al [60] 1200 0-42 Oregano EOs 0-300 Bravo et al [61] 240 0-21 Blend (car, cin) 0-100 Bozkurt et al [62] 1248 [70] 310 0-21 Blend (cin, car) 0-100 Aristimunha et al [12] 930 0-42 Blend (thy, eug, pip) 0-300 Hafeez et al [71] 600 0-42 Blend (men, ane) 0-100 Basmacioğlu-Malayoğlu et al [10] 240 0-42 Blend (car, cum, eug) 0-300 Kim et al [6] 840 0-35 Blend (thy, ane) 0-150 Ding et al [72] 192 0-42 Star anise EOs (ane) 0-200 Masouri et al [33] 288 0-42 Khuzistanica EOs (car) 0-500 Mohiti-Asli and Ghanaatparast-Rashti [73] 200 0-42 Blend (oregano, anise and citrus peel) 0-500 Paraskeuas et al [74] 150 0-42 Blend (men, ane, eug) 0-150 Ri et al [75] 180 0-42 Oregano EOs 0-150 Altop et al [28] 375 0-42 Sweet gum EOs 0-162.2 Giannenas et al [76] 320 0-42 Blend (β-car, men) 0-500 Hosseini and Meimandipour [77] 150 0-42 Thyme EOs 0-80 Mohiti-Asli and Ghanaatparast-Rashti [78] 200 0-42 Blend (oregano, anise and citrus peel) and oregano 0-500 Pirgozliev et al [7] 256 0-21 Blend (cin, car, cap) 0-100 Park and Kim [38] 360 0-42 Blend (thy, eug, pip) 0-300 Reis et al [52] 240 0-42 Blend (car, thy, cin) 0-500 Abdel-Wareth et al [25] 384 0-35 peppermint EOs and men 0-222 Attia et al [11] 216 0-36 Blend (cin, thy) 0-150 Galli et al [53] 135…”

Section: Discussionmentioning

confidence: 99%

Essential oils as growth-promoting additives on performance, nutrient digestibility, cecal microbes, and serum metabolites of broiler chickens: a meta-analysis

et al. 2021

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Objective: The purpose of this meta-analysis was to evaluate the effect of dietary essential oils (EOs) on productive performance, nutrient digestibility, and serum metabolite profiles of broiler chickens and to compare their effectiveness as growth-promoting additives against antibiotics.Methods: Peer-reviewed articles were retrieved from Web of Science, Science Direct, PubMed, and Google scholar and selected based on pre-determined criteria. A total of 41 articles containing 55 experiments with 163 treatment units were eligible for analyses. Data were subjected to a meta-analysis based on mixed model methodology considering the doses of EOs as fixed effects and the different studies as random effects.Results: Results showed a linear increase (p<0.001) on body weight gain (BWG) where Antibiotics (FCR) and average daily feed intake decreased (p<0.001) linearly with an increasing dose of EOs. Positive effects were observed on the increased (p<0.01) digestibility of dry matter, crude protein, ether extract, and cecal Lactobacillus while Escherichia coli (E. coli) population in the cecum decreased (p<0.001) linearly. There was a quadratic effect on the weight of gizzard (p<0.01), spleen (p<0.05), bursa of fabricius (p<0.001), and liver (p< 0.10) while carcass, abdominal fat, and pancreas increased (p<0.01) linearly. The dose of EOs linearly increased high density lipoprotein, glucose, protein, and globulin concentrations (p<0.01). In comparison to control and antibiotics, all type of EOs significantly reduced (p<0.001) FCR and tended to increase (p<0.1) BWG and final body weight. Cinnamaldehyde-compound was the only EOs type showing a tendency to increase (p<0.1) carcass weight, albumin, and protein of serum metabolites while this EOs together with EOs-Blend 1 decreased (p<0.01) E. coli population. Low density lipoprotein concentration decreased (p<0.05) with antibiotics and carvacrol-based compound when compared to the control group.Conclusion: This evidence confirms that EOs are suitable to be used as growth promoters and their economical benefit appears to be promising.

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“…Similar results were reported by Stefanello et al ( 2020 ) and Abdelli et al ( 2020 ), who demonstrated that a blend of OAs improved the BWG and FCR in the intestinal challenged group. Furthermore, under the Eimeria challenge, a blend of benzoic acid and essential oil enhances the growth performance in broilers (Aristimunha et al 2016 ). Better performance could be attributed to the presence of OAs in water and feed, which enhances endogenous GIT enzyme secretion that ultimately produces a positive impact on GIT passage rate and nutrient digestibility in broilers (Khan and Iqbal 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of organic acids on growth performance, intestinal morphology, and immunity of broiler chickens with and without coccidial challenge

et al. 2021

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A total of 360-day-old broiler chicks were allocated into six groups in 2 (Coccidial challenge or not) × 3 (dietary treatments) factorial design. Three dietary treatments including: basic diet, basic diet plus organic acids (OAs) in drinking water, and basic diet plus OAs in the feed with and without coccidial challenge. The OAs in water or feed improved (P < 0.01) average body weight (ABW), average body weight gain (ABWG), and feed conversion ratio (FCR) as compared with the control diet during starter, grower, and whole experimental period. Coccidial challenge decreased BW, ABWG, and average feed intake (AFI), as well as resulted in poor FCR during the starter and whole experimental period (P < 0.05). Though there was no interaction between OAs supplementation and coccidial challenge, the OAs supplementation improved the overall performance with and without coccidial challenge birds on 21 d and 35 d. IgG was found higher (P = 0.03) in broilers fed OAs in feed without the coccidial challenge group. On 18 d, OAs supplementation in feed increased TNF-γ (P = 0.006), whereas the coccidial challenge decreases TNF-γ (P = 0.01) and IL-10 (P = < .0001), and increases IgM (P = 0.03), IgG (P = 0.04) and IgA (P = 0.02). On 29 d, the coccidial challenge increases IgM and IgA. On 18 d, jejunal lesion score was found significantly higher in the coccidial challenged group as compared to OAs supplementation with coccidial challenged groups on 18 d (P < 0.0001) and 29 d (P = 0.03). Crypt depth was higher, and Villus-height to Crypt depth ratio was lower in the coccidial challenge group on 18 and 29 d. The Goblet cells were found higher in the non-coccidial challenge on 18 d. After 18 d, 16S rDNA gene sequence analysis of ileal chyme has shown that coccidial challenge decreases Lactobacillus_reuteri species as compared to the non-challenged group (P = 0.02). After 29, Cyanobacteria abundance reduced (P = 0.014) in the challenged group than the non-challenged group at the phylum level. At the genus level, Lactobacillus (P = 0.036) and unidentified Cyanobacteria (P = 0.01) were found higher in the non-challenged group than the coccidial challenge group. The results indicate that the OAs supplementation showed improved responses in a pattern similar to the non-challenged control group by neutralizing the negative effects of the coccidial challenge.

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A blend of benzoic acid and essential oil compounds as an alternative to antibiotic growth promoters in broiler diets

Cited by 19 publications

References 36 publications

Effect of feed supplementation of Dacryodes edulis parts’ powder as prebiotic on the growth traits, ceca microbiota and blood parameters of local chickens

Effect of feed supplementation of Dacryodes edulis parts’ powder as prebiotic on the growth traits, ceca microbiota and blood parameters of local chickens

Essential oils as growth-promoting additives on performance, nutrient digestibility, cecal microbes, and serum metabolites of broiler chickens: a meta-analysis

Effect of organic acids on growth performance, intestinal morphology, and immunity of broiler chickens with and without coccidial challenge

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