A Biomathematical Model of Particle Clearance and Retention in the Lungs of Coal Miners

Kuempel, Eileen D.; O’Flaherty, Ellen J.; Stayner, Leslie T.; Smith, Randall J.; Green, Francis H. Y.; Vallyathan, Val

doi:10.1006/rtph.2001.1479

Cited by 69 publications

(85 citation statements)

References 55 publications

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“…We used a compartmentalized physiologically based (PB) lung model developed by Tran et al [28][29][30] and Kuempel et al [31] to estimate TiO 2 burden in lung tissue. The PB lung model is capable of describing the progress over time of the retention of particles and the alveolar macrophage (AM)-mediated clearance process in the pulmonary region associated with the particle redistribution and the overload phenomena.…”

Section: Lung-cellular Uptake Modelmentioning

confidence: 99%

Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Liao

Chiang

Chio

2009

Journal of Hazardous Materials

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Section: Lung-cellular Uptake Modelmentioning

confidence: 99%

Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Liao

Chiang

Chio

2009

Journal of Hazardous Materials

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“…Third, the factors such as race and smoking habit could influence the prediction of total SiO 2 lung burden. In fact, these factors could reduce elimination rate of lung and accelerate accumulation of SiO 2 dust (Kuempel et al 2001a;, resulting in an elevating risk of SiO 2 exposurerelated diseases. Hence, we suggest that race and smoking habit can also be incorporated into the PBAD model to improve the predictability in the future research.…”

Section: Limitation and Implicationsmentioning

confidence: 98%

“…Numerous well-established physiologically based mathematical models have been developed in a decade for describing respirable crystalline silica dynamics, inflammatory reaction, and fibrosis development (Kuempel et al 2001a;Tran et al 2001;2002). Cox (2011) used a statistical analysis to investigate the exposure-response relations between crystalline silica and risk of lung pathologies.…”

Section: Responsible Editor: Marcus Schulzmentioning

confidence: 99%

“…a See text for symbol meanings b (Min-Max) c Adopted from Tran et al (2001) d Adopted from Kuempel et al (2001b) to as the Hill coefficient determining the overall shape of the curve. Hill coefficient is a measure of cooperativity.…”

Section: Dose-response Modelmentioning

confidence: 99%

“…We used a compartmentalized physiologically based alveolar deposition (PBAD) model developed by Kuempel et al (2001a; and Tran et al (2001;2002) to estimate SiO 2 lung burden. The PBAD model is capable of describing the long-term total silica burden and the alveolar macrophagemediated clearance processes in the pulmonary region associated with the particle redistribution and the overload phenomena.…”

Section: Alveolar Deposition Modelmentioning

confidence: 99%

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Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease

Liao

Cheng

et al. 2015

Environ Sci Pollut Res

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Inhalation of silica (SiO2) in occupational exposures can cause pulmonary fibrosis (silicosis), lung function deficits, pulmonary inflammation, and lung cancer. Current risk assessment models, however, cannot fully explain the magnitude of silica-induced pulmonary disease risk. The purpose of this study was to assess human health risk exposed to airborne silica dust in Taiwan ceramics manufacturing. We conducted measurements to characterize workplace-specific airborne silica dust in tile and commodity ceramic factories and used physiologically based alveolar exposure model to estimate exposure dose. We constructed dose-response models for describing relationships between exposure dose and inflammatory responses, by which health risks among workers can be assessed. We found that silica contents were 0.22-33.04 % with mean concentration ranges of 0.11-5.48 and 0.46-1763.30 μg m(-3), respectively, in commodity and tile ceramic factories. We showed that granulation workers in tile ceramic factory had the highest total SiO2 lung burden (∼1000 mg) with cumulative SiO2 lung burden of ∼4 × 10(4) mg-year. The threshold estimates with an effect on human lung inflammation and fibrosis are 407.31 ± 277.10 (mean ± sd) and 505.91 ± 231.69 mg, respectively. For granulation workers, long-term exposure to airborne silica dust for 30-45 years was likely to pose severe adverse health risks of inflammation and fibrosis. We provide integrated assessment algorithms required to implement the analyses and maintain resulting concentration of silica dust at safety threshold level in the hope that they will stimulate further analyses and interpretation. We suggest that decision-makers take action to implement platforms for effective risk management to prevent the related long-term occupational disease in ceramics manufacturing.

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Coal

Attfield¹,

Castranova²,

Kuempel³

et al. 2012

Patty's Toxicology

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Coal is an organic, combustible, rock‐like natural substance that occurs in various forms from hard and brittle anthracite to soft and friable lignite. Coal mine dust often contains silica and other minerals found within the coal seam or in the adjacent strata. In the US and other countries, coal miners continue to be at risk of developing chronic lung diseases caused by cumulative exposure to respirable coal mine dust. These diseases can lead to significant lung function impairment, disability, and premature death. Collectively known as “Black Lung”, they include coal workers' pneumoconiosis (CWP), and its more advanced stage, progressive massive fibrosis (PMF), as well as chronic obstructive lung disease (COPD). Many countries have occupational exposure limits for coal mine dust typically based on assessment of the mass of dust collected during a work shift. Surface mining of coal has a considerable environmental impact on the landscape and can impact water supplies.

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A Biomathematical Model of Particle Clearance and Retention in the Lungs of Coal Miners

Cited by 69 publications

References 55 publications

Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Assessing the airborne titanium dioxide nanoparticle-related exposure hazard at workplace

Ceramics manufacturing contributes to ambient silica air pollution and burden of lung disease

Coal

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