A Bioinspired Medical Adhesive Derived from Skin Secretion of Andrias davidianus for Wound Healing

Abstract

Existing surgical tissue adhesives on the market cannot meet the desired demand for clinical operations due to their limited adhesivity or undesired cytotoxicity. A new bioadhesive is derived from the skin secretion of Andrias davidianus (SSAD). This bioinspired SSAD has significantly stronger tissue adhesion than the fibrin glue and improved elasticity and biocompatibility when compared to the cyanoacrylate glue both ex vivo and in vivo. Additionally, the SSAD‐based adhesive decreases skin wound healing time and promotes wound regeneration and angiogenesis. The SSAD‐based adhesive is completely degradable, strongly adhesive, and easily produced from a renewable source. Based on these favorable properties, the SSAD‐based bioadhesive demonstrates potential as a surgical bioadhesive for a broad range of medical applications.

Bioinspired Double‐Dynamic‐Bond Crosslinked Bioadhesive Enables Post‐Wound Closure Care

“…No serious tissue toxicity or inflammation was observed in the surrounding skin tissue from the H&E staining (Figure 4c). We also examined the systemic toxicity of the PL‐Cat/Fe/ODex hydrogel [ 5 ] after eight weeks and the results showed that no toxicity was detected in the main organs (Figure 4d). The results indicate that the PL‐Cat/Fe/ODex hydrogel is safe when applied in vivo.…”

“…Full thickness skin incision [ 5 ] was used as wound model to test the wound closure performance of the PL‐Cat/Fe/ODex hydrogel. First, the ability to repeatedly close the incision was evaluated.…”

“…As illustrated in Figure 5e, after adding DFO, the hydrogel that formed on the skin of the rats can also be dissolved quickly (within 10 min). It normally at least takes several days for wounds to heal after they were closed [ 5,36 ] and during this post‐wound closure time, the closed wounds may be broken by unexpected force or may need additional treatments. As shown by the clinical study, some wounds of the patient showed infection or seroma during the post‐wound closure time, and these closed wounds need to be facilely reopened and further handled.…”

“…[ 3,4 ] Sutureless wound closure, which mainly utilizes bioadhesives, is able to close the wounds by bonding the tissues around the wounds and has shown superiority in producing less pain and scars, enabling quick use and facilitating easy acceptance by patients in comparison with conventional sutures and staples. [ 5–7 ] In the past few years, various bioadhesives have been developed, showing adequate ability in wound closure. These bioadhesives can be conveniently applied through injection and have sufficient adhesive strength as well as low toxicity.…”

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

“…Especially, the adhesive dressing can avoid the secondary damage due to the fragility of soft tissue and localized stress and subsequent removal of non‐degradable sutures or staples, and simplify operation procedures, shorten recovery times, and improve patient care quality. [ 19 ] Catechol group contained substances have good biocompatibility and free radical scavenging ability, which can also show good tissue adhesiveness, self‐healing, and photothermal capacity after complexing with Fe 3+ . Combining the catechol–Fe 3+ coordination cross‐linked synthetic flexible polymer with UPy hydrogen bonding cross‐linked gelatin can prepare synthetic–natural hybrid physical double‐network hydrogel adhesive, integrating the flexible network of synthetic polymer, healing efficiency of natural gelatin, [ 1 ] antioxidant activity, photothermal sterilization, self‐healing and on demand photothermal removal.…”