2022
DOI: 10.1590/1678-9199-jvatitd-2021-0056
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A biocomplex to repair experimental critical size defects associated with photobiomodulation therapy

Abstract: Background: The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. The incorporation of particulate biomaterials into three-dimensional fibrin bioproducts together with photobiomodulation therapy (PBM) has potential and can improve regenerative medicine procedures. The objective of this experiment was to evaluate the effects of PBM therapy on critical size defects filled with xenogenic bone substitute associated with fibrin biopoly… Show more

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Cited by 8 publications
(16 citation statements)
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References 85 publications
(114 reference statements)
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“…The increasing bone formation observed over time in this research was also reported in studies that used similar methodologies [ 20 , 44 ]. These data demonstrate that PBM may have positive effects on bone tissue, improving the quality and density of newly formed bone [ 44 , 46 , 47 ].…”
Section: Resultssupporting
confidence: 86%
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“…The increasing bone formation observed over time in this research was also reported in studies that used similar methodologies [ 20 , 44 ]. These data demonstrate that PBM may have positive effects on bone tissue, improving the quality and density of newly formed bone [ 44 , 46 , 47 ].…”
Section: Resultssupporting
confidence: 86%
“…In this period of analysis, it is possible to observe the presence of vascular sprouts in the G4/BFB + PBM group, which may be due to the effects of PBM therapy on the local microcirculation [ 46 ]. In addition to PBM, the fibrin biopolymer also contributed to stimulate angiogenic factors and neovascularization, as observed in previous studies [ 20 , 44 ]. The analyses performed at 42 postoperative days shows that there was an advance in bone formation in all experimental groups, but without the complete closure of the defects.…”
Section: Resultssupporting
confidence: 58%
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