A biocompatible Zr-based metal-organic framework UiO-66-PDC as an oral drug carrier for pH-response release

Wang, Yan; Lin, Wenxin; Yu, Shijiang; Huang, Xiajuan; Lang, Xiurui; He, Qing; Gao, Linhui; Zhu, Hongliang; Chen, Jianjun

doi:10.1016/j.jssc.2020.121805

Cited by 42 publications

(19 citation statements)

References 37 publications

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“…42 Ibuprofen sodium (IBUNa), an anti-inflammatory medicine, was also loaded into UiO-66-PDC (PDC = 2,5-pyridinedicarboxylic acid). 43 Tan and colleagues reported Zr-based MOFs with Ca 2+ , pH, and temperature triple responsiveness for drug release in bone diseases. 44 In addition, cancer cells were treated with dichloroacetate and 5fluorouracil (5-FU) delivered by Zr-MOFs in a dual delivery system.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Lin and colleagues reported using a Zr cluster-based MOF UiO-68-NH 2 to deliver cisplatin and siRNA simultaneously to improve the treatment efficiency . Ibuprofen sodium (IBUNa), an anti-inflammatory medicine, was also loaded into UiO-66-PDC (PDC = 2,5-pyridinedicarboxylic acid) . Tan and colleagues reported Zr-based MOFs with Ca 2+ , pH, and temperature triple responsiveness for drug release in bone diseases .…”

Section: Introductionmentioning

confidence: 99%

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MOF-801 as a Nanoporous Water-Based Carrier System for In Situ Encapsulation and Sustained Release of 5-FU for Effective Cancer Therapy

Parsaei

Akhbari

2022

Inorg. Chem.

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Nanoporous metal−organic frameworks (MOFs) have been gaining a reputation for their drug delivery applications. In the current work, MOF-801 was successfully prepared by a facile, cost-efficient, and environmentally friendly approach through the reaction of ZrCl 4 and fumaric acid as organic linkers to deliver 5-fluorouracil (5-FU). The prepared nanostructure was fully characterized by a series of analytical techniques including Fourier transform infrared spectroscopy, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive Xray spectroscopy, UV−vis spectroscopy, 1 H NMR spectroscopy, thermogravimetric analysis, high-performance liquid chromatography, and Brunauer−Emmett−Teller analysis. MOF-801 could be used for the delivery of the anticancer drug 5-FU due to its high surface area, suitable pore size, and biocompatible ingredients. Based on in vitro loading and release studies, a high 5-FU loading capacity and pH-dependent drug release behavior were observed. Moreover, the interactions between the structure of MOFs and 5-FU were investigated through Monte Carlo simulation calculations. An in vitro cytotoxicity test was done, and the results indicated that 5-FU@MOF-801 was more potent than 5-FU on SW480 cancerous cells, indicating the highlighted role of this drug delivery system. Finally, the kinetics of drug release was investigated.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MOF-801 as a Nanoporous Water-Based Carrier System for In Situ Encapsulation and Sustained Release of 5-FU for Effective Cancer Therapy

Parsaei

Akhbari

2022

Inorg. Chem.

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“…One of the most investigated Zr-based MOF drug-controlled release systems is UiO-66. − A smart temperature-response drug release of UiO-66-PNIPAM (poly( N -isopropylacrylamide) was reported . 2,5-Pyridinedicarboxylic acid ligands were applied to the synthesis of UiO-66-PDC as a pH-response oral drug carrier . The preparation of k-carrageenan/tramadol@UiO-66 also was reported as a pH-responsive delivery vehicle .…”

Section: Introductionmentioning

confidence: 99%

“…75 2,5-Pyridinedicarboxylic acid ligands were applied to the synthesis of UiO-66-PDC as a pHresponse oral drug carrier. 76 The preparation of k-carrageenan/ tramadol@UiO-66 also was reported as a pH-responsive delivery vehicle. 77 The incorporation of doxorubicin (DOX) and folic acid (FA) into UiO-66 is investigated.…”

Section: Introductionmentioning

confidence: 99%

Smart Multifunctional UiO-66 Metal–Organic Framework Nanoparticles with Outstanding Drug-Loading/Release Potential for the Targeted Delivery of Quercetin

Parsaei

Akhbari

2022

Inorg. Chem.

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Herein, UiO-66 and its two functional analogs (with −NO 2 and −NH 2 functional groups) were synthesized, and their potential ability as pH stimulus nanocarriers of quercetin (QU), an anticancer agent, was studied. UiO-66 is a low-toxicity, biocompatible metal−organic framework with a large surface area and good stability, which can be prepared through a facile and inexpensive method. Before and after drug loading, various analyses were conducted to characterize the synthesized nanocarriers. Moreover, Monte Carlo simulations were performed to investigate their structures and interactions with quercetin. The most promising drug loading potential and prolonged drug release (over 25 days) were observed in QU@UiO-66-NO 2 with 37% drug loading content, which was the best-tested sample that exhibited a higher release rate under acidic conditions (pH = 5) than that in normal cells (pH = 7.4). This behavior is known as pH-stimuluscontrolled ability. The cell treatment with free QU, UiO-66-R, and QU@UiO-66-R (R = −H, −NO 2 , and −NH 2 ) was performed, and an MTT assay was conducted on HEK-293 and MDA-MB-231 cells for the cytotoxicity study. Additionally, the kinetic modeling of drug release was investigated on the basis of the analysis of the drug release profiles.

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“…None of the UiO MOFs exhibited substantial cytotoxicity at either incubation time, except for UiO-66-NH 2 ; at a 200 µM dose and 24 h of incubation, this material showed moderate cytotoxicity to HepG2 cells. The good biocompatibility of UiO MOFs has been stated in [ 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Loaded Core–Shell UiO-66@SiO2 Metal–Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment

et al. 2022

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Beneficial features of biocompatible high-capacity UiO-66 nanoparticles, mesoporous SiO2, and folate-conjugated pluronic F127 were combined to prepare the core–shell UiO-66@SiO2/F127-FA drug delivery carrier for targeted cellular uptake in cancer treatment. UiO-66 and UiO-66-NH2 nanoparticles with a narrow size and shape distribution were used to form a series of core–shell MOF@SiO2 structures. The duration of silanization was varied to change the thickness of the SiO2 shell, revealing a nonlinear dependence that was attributed to silicon penetration into the porous MOF structure. Doxorubicin encapsulation showed a similar final loading of 5.6 wt % for both uncoated and silica-coated particles, demonstrating the potential of the nanocomposite’s application in small molecule delivery. Silica coating improved the colloidal stability of the composites in a number of model physiological media, enabled grafting of target molecules to the surface, and prevented an uncontrolled release of their cargo, with the drawback of decreased overall porosity. Further modification of the particles with the conjugate of pluronic and folic acid was performed to improve the biocompatibility, prolong the blood circulation time, and target the encapsulated drug to the folate-expressing cancer cells. The final DOX-loaded UiO-66@SiO2/F127-FA nanoparticles were subjected to properties characterization and in vitro evaluation, including studies of internalization into cells and antitumor activity. Two cell lines were used: MCF-7 breast cancer cells, which have overexpressed folate receptors on the cell membranes, and RAW 264.7 macrophages without folate overexpression. These findings will provide a potential delivery system for DOX and increase the practical value of MOFs.

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A biocompatible Zr-based metal-organic framework UiO-66-PDC as an oral drug carrier for pH-response release

Cited by 42 publications

References 37 publications

MOF-801 as a Nanoporous Water-Based Carrier System for In Situ Encapsulation and Sustained Release of 5-FU for Effective Cancer Therapy

MOF-801 as a Nanoporous Water-Based Carrier System for In Situ Encapsulation and Sustained Release of 5-FU for Effective Cancer Therapy

Smart Multifunctional UiO-66 Metal–Organic Framework Nanoparticles with Outstanding Drug-Loading/Release Potential for the Targeted Delivery of Quercetin

Doxorubicin-Loaded Core–Shell UiO-66@SiO2 Metal–Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment

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