A biocompatible two-photon absorbing fluorescent mitochondrial probe for deepin vivobioimaging

Abstract

Mitochondria, key organelles which keep in tune with energy demands for eukaryotic cells, are firmly associated with neurological conditions and post-traumatic rehabilitation. In vivo fluorescence imaging of mitochondria, especially with...

Noncancerous disease-targeting AIEgens

“…14H and I). 180 Compared to conventional fluorescent compounds, AIEgens show great advantages in the imaging of CVDs, including the long wavelength emission in the NIR-IIb region that promotes the bioimaging of deep tissues, high QYs that promote fluorescence intensity, high clarity, and enhanced SNRs, especially in cerebral angiography, [189][190][191][192][193][194][195] expand the progresses of CVDs. Hence, they should be applied for bioimaging in more animal and non-cancer disease models.…”

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

“…This ultrahigh luminescence stability of octahedral Mo 6 nanoclusters originated from their strong and homogeneous interactions with the host matrix, which can greatly inhibit any unwanted phase segregation or leaching of integrated Mo 6 nanoclusters. Known for about 90 years, luminescence induced via two-photon absorption is still an appealing and critical research direction that is of particular relevance when dealing with high-resolution imaging and photocytotoxic therapy. − Octahedral Mo 6 clusters, with evidence of two-photon absorption-induced highly stable NIR-I phosphorescence, will afford new opportunities in broadening the library of in vivo bioimaging probes.…”

Cocrystal Approach to Modulate the Photoluminescent Properties of a GFP Chromophore Analogue: Role of Halogen/Hydrogen Bonding in Achieving a Wide Range of Solid-State Fluorescence Emissions

“…Organic solid-state chromophores have received great attention in recent years because of their potential optoelectronic applications in light-emitting diodes, optical waveguides, lasers, sensors, and two-photon fluorescent materials. − These materials deliver and illuminate facts via modern technologies due to their flexibility, brightness, easy processability, tunable photophysical properties, high optical gain, and possible biocompatibility. They have been extensively used in photonics, optoelectronic devices, biological probes, and fluorescent sensors. − In general, most applications require solids or aggregate-state luminous materials, such as thin films, bulk crystals (polymorphs/cocrystals/salts), and nanoparticles. − However, the planar aromatic structures of conventional organic chromophores make these materials susceptible to the well-known aggregation-caused quenching (ACQ) effect or help in aggregation-induced emission (AIE). − The ACQ or AIE effect is facilitated through π-stacking and other physical interactions, including energy transfer and intermolecular or intramolecular charge transfer.…”