A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies

Mansouri, Hedieh; Gholibegloo, Elham; Mortezazadeh, Tohid; Yazdi, Mohammad Hossein; Ashouri, Fatemeh; Malekzadeh, Reza; Najafi, Atabak; Foroumadi, Alireza; Khoobi, Mehdi

doi:10.1016/j.carbpol.2020.117262

Cited by 33 publications

(22 citation statements)

References 58 publications

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“…In vivo assessment of the nanoparticles revealed an enhancement of both T1 and T2 contrast in subcutaneous tumors of mice, generated by 4T1 cells implantation in the right flanks. Moreover, the tumor shrinking was registered, and it was highly significant compared to free Curcumin treatment [141].…”

Section: Biological Analysis Of Magnetite-based Spions Functionalized...mentioning

confidence: 94%

Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

et al. 2022

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The enormous development of nanomaterials technology and the immediate response of many areas of science, research, and practice to their possible application has led to the publication of thousands of scientific papers, books, and reports. This vast amount of information requires careful classification and order, especially for specifically targeted practical needs. Therefore, the present review aims to summarize to some extent the role of iron oxide nanoparticles in biomedical research. Summarizing the fundamental properties of the magnetic iron oxide nanoparticles, the review’s next focus was to classify research studies related to applying these particles for cancer diagnostics and therapy (similar to photothermal therapy, hyperthermia), in nano theranostics, multimodal therapy. Special attention is paid to research studies dealing with the opportunities of combining different nanomaterials to achieve optimal systems for biomedical application. In this regard, original data about the synthesis and characterization of nanolipidic magnetic hybrid systems are included as an example. The last section of the review is dedicated to the capacities of magnetite-based magnetic nanoparticles for the management of oncological diseases.

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Section: Biological Analysis Of Magnetite-based Spions Functionalized...mentioning

confidence: 94%

Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

et al. 2022

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“…β-CD (1 mmol) was next added to the asprepared dispersions followed by addition Et 3 N (1 mL). They were stirred at room temperature for 3 h. Then, EPI (8 mmol) was added and the mixtures were stirred for another 3 h. The ZnO NMs coated with PCD (ZnOS@PCD and ZnOR@PCD NPs) were nally collected with centrifugal force, washed with ethanol and dried in vacuum for 24 h [31,33].…”

Section: Synthesis Of the Zno Nms Coated With Pcdmentioning

confidence: 99%

“…In the TGA curves of ZnOS@PCD and ZnOR@PCD NMs, there are mainly two steps of weight losses at temperature range of below 180 ºC and between 180-500 ºC with similar pattern for the both NMs. The rst and second sharp weight losses (about 4 and 16%, respectively) could be attributed to the desorption of the solvent molecule and degradation of the PCD shell coated on the surface of ZnO NPs, respectively [31,33].…”

Section: Tga Analysismentioning

confidence: 99%

“…The performance of β-CD as a carrier could be improved via its modi cation and polymerization using bifunctional crosslinking agents like dianhydrides [29,30]. In recent years, polycyclodextrins (PCDs) decorated on the surface of MeO NPs has attracted great attentions for biological application [31][32][33]. PCDs are porous polymeric matrix with large amount of carbonyl and hydroxyl groups with the capability to be easinly functionalized by appropriate ligands and ability to improve CUR loading, solubility and stability [29,34].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Gholibegloo¹,

Akbari²,

Torshabi³

et al. 2022

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Antimicrobial photodynamic therapy (aPDT) is a high potential strategy for the treatment of microbial infections in endodontics. In this study, a novel antibacterial agent was designed and prepared based on the two morphologies of zinc oxide nanomaterials (NMs) as ZnO nanosphere (ZnOS) and ZnO nanorod (ZnOR). Their surfaces were coated with carnosine (CAR)-functionalized polycyclodextrin (ZnO@PCD-CAR) for higher payload of curcumin (CUR) as a photosensitizer (PS). This system was characterized using FT-IR, XRD, TGA, FE-SEM, zeta potential analysis and UV-visible spectroscopy. The colony forming unit (CFU) assay was carried out to evaluate the antimicrobial properties of the nanoformulations againts Enterococcus faecalis (E. Faecalis). The target products (ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR) exhibited a light stability approximately by 2.9 and 2.8 fold, respectively, higher than the free CUR. Compared to the bare CUR, these materials indicated more stability againts pH variations. ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR NMs-mediated aPDT, significantly declined the count of E. Faecalis strains about 1.5 and 2 log (P < 0.05). Due to the high CUR loading, proper stability and significant inhibitory effects against E. Faecalis, ZnO@PCD-CAR/CUR could be considered as a promising antimicrobial agent in aPDT for efficient treatment of root canal infections.

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“…A new theranostic nanoplatform able to release curmumin (CUR) encapsulated into a polymer of β-CDs (PCD) was reported. 95 Simultaneously, T1 and T2 contrast agents were associated using DTPA-Gd and Fe 3 O 4 nanoparticles both covalently immobilized on PCD, respectively. The efficiency of Fe 3 O 4 @PCD-DTPA-Gd showed no toxicity against normal and cancerous cell lines.…”

Section: Cyclodextrins Covalently Linked To Contrast Agentsmentioning

confidence: 99%

Cyclodextrins: promising scaffolds for MRI contrast agents

2021

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A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo studies

Cited by 33 publications

References 58 publications

Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

Biomedical Applications of Iron Oxide Nanoparticles: Current Insights Progress and Perspectives

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Cyclodextrins: promising scaffolds for MRI contrast agents

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