Cyclodextrins: promising scaffolds for MRI contrast agents

Sembo-Backonly, Berthe Sandra; Estour, François; Gouhier, Géraldine

doi:10.1039/d1ra04084g

Cited by 7 publications

(10 citation statements)

References 106 publications

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“…In recent years, CD‐based nanogels have also gained importance in the field of nuclear imaging. [ 243–245 ] As mentioned in the earlier chapters, CD nanogels have distinctive features derived from their host–guest complexation properties. This unique behavior of CDs can offer several utilities such as constructing radiolabeled drug delivery/releasing systems, [ 208 ] and designing pre‐targeting platforms.…”

Section: Radiolabeled Nanogelsmentioning

confidence: 99%

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Kubeil,

Suzuki,

Casulli

et al. 2023

Adv Healthcare Materials

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Nanogels open up access to a wide range of applications and offer among others hopeful approaches for use in the field of biomedicine. This review provides a brief overview of current developments of nanogels in general, particularly in the fields of drug delivery, therapeutic applications, tissue engineering and sensor systems. Specifically, cyclodextrin (CD)‐based nanogels are important because they have exceptional complexation properties and are highly biocompatible. Nanogels as a whole and CD‐based nanogels in particular can be customized in a wide range of sizes and equipped with a desired surface charge as well as containing additional molecules inside and outside, such as dyes, solubility‐mediating groups or even biological vector molecules for pharmaceutical targeting. Currently, biological investigations are mainly carried out in vitro, but more and more in vivo applications are gaining importance. Modern molecular imaging methods are increasingly being used for the latter. Due to an extremely high sensitivity and the possibility of obtaining quantitative data on pharmacokinetic and pharmacodynamic properties, nuclear methods such as single photon emission computed tomography (SPECT) and positron emission tomography (PET) using radiolabeled compounds are particularly suitable here. The use of radiolabeled nanogels for imaging, but also for therapy, is being discussed.This article is protected by copyright. All rights reserved

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Section: Radiolabeled Nanogelsmentioning

confidence: 99%

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Kubeil,

Suzuki,

Casulli

et al. 2023

Adv Healthcare Materials

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Section: Introductionmentioning

confidence: 99%

“…Other parameters that affect relaxivity are τ M (residence time of water molecule in the coordination sphere) and τ R (rotational correlation time); large size and high molecular weight organic ligand can positively affect these parameters resulting in an increase of relaxivity. 7 Despite all the advantages of GBCAs, it is necessary to take into account that the gadolinium is extremely toxic as free ion. Therefore, for clinical use, it must be bound in a complex of high stability and exhibit a long-term resistance to Gd(III) ion transmetallation or transchelation.…”

mentioning

confidence: 99%

Advances in MRI: Peptide and peptidomimetic‐based contrast agents

Pierri,

Schettini

2023

Journal of Peptide Science

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Magnetic resonance imaging (MRI) is a common medical imaging technique that provides three‐dimensional body images. MRI contrast agents improve image contrast by raising the rate of water proton relaxation in specific tissues. Peptides and peptidomimetics act as scaffolds for MRI imaging agents because of their increased size and offer the possibility to engine a higher hydration value within the design. The design of a new Gd‐based contrast agent must take into account high stability constants to avoid free Gd(III), with the subsequent nephrotoxicity, and high relaxivity values. This review analyzes various synthetic approaches, reports studies of relaxometric parameters, and focuses on the description and application of Gd(III)‐chelates based on peptide and peptidomimetic scaffolds. In addition, the X‐ray molecular structures of three DOTA complexes will be reported to emphasize the necessity of using the X‐ray diffraction analysis to identify the coordination sphere of the metals and the mechanism of action of the compounds.

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“…For the effective use of lanthanide complex compounds for these purposes, it is necessary to ensure their bioavailability and target properties, as well as guarantee their safety and low toxicity to humans [ 7 ]. The latter quality is determined by the thermodynamic and kinetic stability of complexes of lanthanide ions [ 8 , 9 , 10 , 11 , 12 ]. However, this problem has not yet been fully resolved.…”

Section: Introductionmentioning

confidence: 99%

Hyperbranched Polyester Polyfumaratomaleate Doped with Gd(III) and Dy(III) Ions: Synthesis, Structure and Properties

et al. 2022

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For the first time, metal–polymer complexes have been synthesized using hyperbranched polyester polyfumaratomaleate as a matrix, the structure of which has been established by 1H NMR, IR, electron spectroscopy, and elemental analysis methods. The formation of complexes with Gd(III) and Dy(III) ions involving fumarate and maleate groups of the polyester was proved by IR and electron spectroscopy methods. It was established that the structure of the coordination units has the form of a square antiprism. The compositions and conditional logarithms of the stability constants of the complexes were determined. It was established that complexation with lanthanide ions promotes emission enhancement in the ligand.

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Cyclodextrins: promising scaffolds for MRI contrast agents

Abstract: This review highlights that supramolecular associations using host–guest inclusion complexation and covalent linkages can improve the image contrast, the sensitivity, and the efficiency of MRI diagnosis.

Cited by 7 publications

References 106 publications

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Exploring the Potential of Nanogels: From Drug Carriers to Radiopharmaceutical Agents

Advances in MRI: Peptide and peptidomimetic‐based contrast agents

Hyperbranched Polyester Polyfumaratomaleate Doped with Gd(III) and Dy(III) Ions: Synthesis, Structure and Properties

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