A biocompatible porous Mg-gallate metal–organic framework as an antioxidant carrier

Cooper, Lucy; Hidalgo, Tania; Gorman, Martin; Lozano‐Fernández, Tamara; Simón‐Vázquez, Rosana; Olivier, Camille; Guillou, Nathalie; Serre, Christian; Martineau, Charlotte; Taulèlle, Francis; Borges, Daiane Damasceno; Maurin, Guillaume; González-Fernández, África; Horcajada, Patricia; Devic, Thomas

doi:10.1039/c5cc00745c

Cited by 108 publications

(78 citation statements)

References 28 publications

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“…The thermal behavior of MIL‐163 was evaluated by thermogravimetric analysis under oxygen flow (Figure S17). As observed in the case of other solids built up from gallic acid,31, 32, 37, 40 MIL‐163 has a rather low decomposition temperature (ca. 210 °C) compared to Zr carboxylate MOFs 7.…”

Section: Methodsmentioning

confidence: 69%

A Robust Infinite Zirconium Phenolate Building Unit to Enhance the Chemical Stability of Zr MOFs

et al. 2015

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Section: Methodsmentioning

confidence: 69%

A Robust Infinite Zirconium Phenolate Building Unit to Enhance the Chemical Stability of Zr MOFs

et al. 2015

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“…Su and co-workers reported an anionic Zn-based MOF that exhibited a remarkable capacity for cationic drug hosting and controlled delivery9. Devic and co-workers prepared a biocompatible porous Mg-based MOF under environmentally friendly conditions as an antioxidant carrier10. Although these MOFs exhibit drug hosting and controlled delivery capability, they are not capable of the targeted delivery of drug molecules, resulting in significant toxicity to normal cells and limiting their biomedical applications.…”

mentioning

confidence: 99%

Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport

Gao

Xiao

Baigude

et al. 2016

Sci Rep

127

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An advanced multifunctional, hollow metal-organic framework (MOF) drug delivery system with a high drug loading level and targeted delivery was designed and fabricated for the first time and applied to inhibit tumour cell growth. This hollow MOF targeting drug delivery system was prepared via a simple post-synthetic surface modification procedure, starting from hollow ZIF-8 successfully obtained for the first time via a mild phase transformation under solvothermal conditions. As a result, the hollow ZIF-8 exhibits a higher loading capacity for the model anticancer drug 5-fluorouracil (5-FU). Subsequently, 5-FU-loaded ZIF-8 was encapsulated into polymer layers (FA-CHI-5-FAM) with three components: a chitosan (CHI) backbone, the imaging agent 5-carboxyfluorescein (5-FAM), and the targeting reagent folic acid (FA). Thus, an advanced drug delivery system, ZIF-8/5-FU@FA-CHI-5-FAM, was fabricated. A cell imaging assay demonstrated that ZIF-8/5-FU@FA-CHI-5-FAM could target and be taken up by MGC-803 cells. Furthermore, the as-prepared ZIF-8/5-FU@FA-CHI-5-FAM exhibited stronger cell growth inhibitory effects on MGC-803 cells because of the release of 5-FU, as confirmed by a cell viability assay. In addition, a drug release experiment in vitro indicated that ZIF-8/5-FU@FA-CHI-5-FAM exhibited high loading capacity (51%) and a sustained drug release behaviour. Therefore, ZIF-8/5-FU@FA-CHI-5-FAM could provide targeted drug transportation, imaging tracking and localized sustained release.

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“…This allows reducing the amount of nonactive undesirable compounds to be administered at the benefit of an anticipated decrease of toxicity. Numerous active ligands have been proposed to date to produce bioMOFs: peptides (metal peptide frameworks), nucleobases, carbohydrates, porphyrines, as well as some active ingredients . Unfortunately, most of these bioMOFs are still at their initial stages of development and a very few of them have undergone in vivo preclinical evaluation.…”

Section: Toxicity: From In Vitro To In Vivo Evaluationmentioning

confidence: 99%

“…Indeed, the synthesis of most bioMOFs requires the use of toxic solvents such as dimethylformamide or pyridine . Thus, to prepare suitable nanomaterials relevant for clinical applications, alternative “green” synthesis routes are urgently needed as it has already been done for other MOFs …”

Section: Toxicity: From In Vitro To In Vivo Evaluationmentioning

confidence: 99%

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

et al. 2018

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In the past few years, numerous studies have demonstrated the great potential of nano particles of metal-organic frameworks (nanoMOFs) at the preclinical level for biomedical applications. Many of them were reported very recently based on their bioactive composition, anticancer application, or from a general drug delivery/theranostic perspective. In this review, the authors aim at providing a global view of the studies that evaluated MOFs' biomedical applications at the preclinical stage, when in vivo tests are described either for pharmacological applications or for toxicity evaluation. The authors first describe the current surface engineering approaches that are crucial to understand the in vivo behavior of the nanoMOFs. Finally, after a detailed and comprehensive analysis of the in vivo studies reported with MOFs so far, and considering the general evolution of the drug delivery science, the authors suggest new directions for future research in the use of nanoMOFs for biomedical applications.

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A biocompatible porous Mg-gallate metal–organic framework as an antioxidant carrier

Cited by 108 publications

References 28 publications

A Robust Infinite Zirconium Phenolate Building Unit to Enhance the Chemical Stability of Zr MOFs

A Robust Infinite Zirconium Phenolate Building Unit to Enhance the Chemical Stability of Zr MOFs

Fabrication of functional hollow microspheres constructed from MOF shells: Promising drug delivery systems with high loading capacity and targeted transport

Nanoparticles of Metal‐Organic Frameworks: On the Road to In Vivo Efficacy in Biomedicine

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