A biocompatible PAA-Cu-MOP hydrogel for wound healing

Chen, Linlin; Qin, Yu; Cheng, Jing; Cheng, Yi; Lu, Zhixiang; Liu, Xiaolan; Yang, Shuo; Lu, Shuhan; Zheng, Liyan; Cao, Qiue

doi:10.1039/c9ra10031h

Cited by 17 publications

(10 citation statements)

References 63 publications

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“…In addition, the CP@Tf-hy, which can adhere to the hemorrhage position, can quickly construct a physical barrier to prevent wound bleeding . Moreover, the Cu ions on the hydrogel may also contribute to the hemostatic ability because Cu ions have procoagulant capacity …”

Section: Resultsmentioning

confidence: 99%

“…61 Moreover, the Cu ions on the hydrogel may also contribute to the hemostatic ability because Cu ions have procoagulant capacity. 62 Together, we propose that CP@Tf-hy eliminates bacteria through the following mechanisms: (i) In an acidic bacterial microenvironment, the CP@Tf-hy can generate •OH by the Fenton reaction of copper ions and self-supplied H 2 O 2 to damage bacteria. (ii) The CP@Tf-hy can release Cu 2+ to deplete GSH, and then, the produced Cu + induces an enhanced Fenton reaction with self-supplied H 2 O 2 from CP@Tf NPs and the endogenous H 2 O 2 in bacteria.…”

Section: 7mentioning

confidence: 96%

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A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

Wang

Yao

et al. 2022

ACS Appl. Bio Mater.

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Bacterial infection has been a great threat to wounds due to the abuse of antibiotics and drug resistance. Elaborately constructing an efficient antibacterial strategy for accelerated healing of bacteria-infected wounds is of great importance. Herein, we develop a transferrin-conjugated copper peroxide nanoparticlehydrogel (denoted as CP@Tf-hy) wound dressing with no toxicity to mammalian cells at a test dosage. When exposed to an initial acidic wound environment, the CP@Tf-hy simultaneously displays in situ self-supplied H 2 O 2 and pH-responsive release of Fenton catalytic copper ions accompanied by highly toxic hydroxyl radical (•OH) generation against antibiotic-resistant bacteria. Meanwhile, the positively charged CP@Tf-hy can efficiently trap and restrain negatively charged bacteria to the range of •OH destruction to greatly overcome its intrinsic disadvantages of short life and diffusion distance. Importantly, the CP@Tf-hy consumes the bacterial overexpressed antioxidant glutathione while boosting Fenton catalytic copper(I) ions to generate more •OH. The synergistic effects of the enhanced Fenton reaction, responsive copper ion release, and bacterial trapping can achieve high bacterial elimination efficacy (7 log reduction). In vivo investigations demonstrate that the porous CP@Tf-hy significantly promotes hemostasis, cell proliferation, and migration of the wound, consequently accelerating bacteria-infected wound healing. The safe, low-cost, and all-in-one CP@Tf-hy holds great prospects as an antibacterial dressing for rapid resistant bacteria-infected purulent wound healing.

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Section: Resultsmentioning

confidence: 99%

Section: 7mentioning

confidence: 96%

A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

Wang

Yao

et al. 2022

ACS Appl. Bio Mater.

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“…After testing, PaA-Cu-MOP hydrogel can promote cell proliferation and blood vessel generation, up-regulate cytokines, and even outperform recombinant human epidermal growth factors. Therefore, PaA-Cu-MOP hydrogel has excellent biocompatibility and can accelerate wound healing [ 99 ].…”

Section: Performance Of Antibacterial Hydrogelsmentioning

confidence: 99%

Progress in Antibacterial Hydrogel Dressing

Liu

Jiang

et al. 2022

Gels

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Antibacterial hydrogel has excellent antibacterial property and good biocompatibility, water absorption and water retention, swelling, high oxygen permeability, etc.; therefore, it widely applied in biomedicine, intelligent textiles, cosmetics, and other fields, especially for medical dressing. As a wound dressing, the antibacterial hydrogel has the characteristics of absorbing wound liquid, controlling drug release, being non-toxic, being without side effects, and not causing secondary injury to the wound. Its preparation method is simple, and can crosslink via covalent or non-covalent bond, such as γ-radiation croFsslinking, free radical polymerization, graft copolymerization, etc. The raw materials are easy to obtain; usually these include chondroitin sulfate, sodium alginate, polyvinyl alcohol, etc., with different raw materials being used for different antibacterial modes. According to the hydrogel matrix and antibacterial mode, the preparation method, performance, antibacterial mechanism, and classification of antibacterial hydrogels are summarized in this paper, and the future development direction of the antibacterial hydrogel as wound dressing is proposed.

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“…[4,7,8] Owing to their intriguing structures and their potential for a variety of applications, MOP have recently attracted considerable attention such as biomedicine, [9][10][11][12] catalysis, [7,[12][13][14] molecular sensing, [16] gas adsorption [17][18][19] and drug delivery. [20,21] Inspired by the superior performance of copper complexes in catalyzing oxidation ability in nature, our group have reported that Cu-MOP display excellent peroxidase mimicking enzyme activity in the physiological pH environment and were widely utilized in biosensing, [22] antibacterial [23] and cell protection [24] in recent years.…”

Section: Introductionmentioning

confidence: 99%

Morphology‐Dependent Peroxidase Mimicking Enzyme Activity of Copper Metal‐Organic Polyhedra Assemblies

Liu

Bao-ru

Bian

et al. 2021

Chemistry A European J

Self Cite

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The morphology of nanomaterials (geometric shape and dimension) play a significant role in its various physical and chemical properties. Thus, it is essential to link morphology with performance in specific applications. For this purpose, the morphology of copper metal-organic polyhedra (Cu-MOP) can be modulated through distinct assembly process, which facilitates the exploration of the relationship between morphology and catalytic performance. In this work, the assemblies of Cu-MOP with three different morphologies (nanorods, nanofibers and nanosheets) were facilely prepared by the variation of solvent mixture of N, N-dimeth-ylformamide (DMF) and methanol, revealed the important role of the interaction between the surface group and the solvent on the morphology of these assemblies. Cu-MOP nanofibers exhibited the highest mimetic peroxidase enzyme activity over the Cu-MOP nanosheets and nanorods, which have been utilized in the detection of glucose. Cu-MOPs assemblies with tunable morphology accompanied with adjustable mimic peroxidase activity, had great potential applications in the field of bioanalytical chemistry and biomedicals.

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A biocompatible PAA-Cu-MOP hydrogel for wound healing

Abstract: PAA-Cu-MOP hydrogel prepared by a facile mixing and ultrasonic procedure showed an excellent wound healing behavior which was better than that of commercial recombinant human epidermal growth factor.

Cited by 17 publications

References 63 publications

A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

A Copper Peroxide Fenton Nanoagent-Hydrogel as an In Situ pH-Responsive Wound Dressing for Effectively Trapping and Eliminating Bacteria

Progress in Antibacterial Hydrogel Dressing

Morphology‐Dependent Peroxidase Mimicking Enzyme Activity of Copper Metal‐Organic Polyhedra Assemblies

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