A bioactive triterpene from Lantana camara

Barre, Juanita T.; Bowden, Bruce F.; Coll, John C.; Jesus, J. de; Fuente, V. E. De La; Janairo, Gerardo C.; Ragasa, Consolacion Y.

doi:10.1016/s0031-9422(96)00805-9

Cited by 113 publications

(61 citation statements)

References 3 publications

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“…Lantana camara has been studied in detail from a phytochemical stand point in diverse parts of the world, and some have reported antimicrobial activity for these extracts. In contrast to our results, bioactive triterpenes with antimicrobial activity against Staphylococcus aureus and Salmonella typhimurium have been reported in Lantana camara (Barre et al, 1997).…”

Section: Resultscontrasting

confidence: 99%

“…The species examined in this study have not been reported previously as having medicinal properties, except for Allionia incarnata, antiproliferative activity ( Donaldson & Cates, 2004), Lantana camara, antiinflammatory, antithrombin and antimalarial activity (Weenen et al, 1990;Barre et al, 1997;O'Neill et al, 1998, Weir et al, 1998Subhalakshmi & Banasri, 2006); Guazuma ulmifolia,antibacterial and antihyperglycemic activities (Cáceres et al, 1990;Alarcón-Aguilera et al, 1998;Camporese et al, 2003); Baccharis glutinosa (Verastegui et al, 1996); Ambrosia confertiflora, antiproliferative activity (Donaldson & Cates, 2004); Antigonon leptopus, antithrombin activity (Chistokhodova et al, 2002); Lysiloma divaricata, anti-inflammatory and antibacterial activities (Bork et al, 1996;Perez et al, 2001); Parkinsonia aculeata, antispermatogenic activity (Gupta et al, 2007); and Pithecellobium dulce, antibacterial activity (Shanmugakumar et al, 2006). Baccharis glutinosa ethanolic extracts have been investigated previously and their antimicrobial activity against bacteria and fungi was determined (Verastegui et al, 1996).…”

Section: Resultsmentioning

confidence: 94%

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Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Salazar

Verdugo

López

et al. 2008

Pharmaceutical Biology

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Antibacterial activities of methanol and hexane extracts of thirty plants, traditionally used to cure gastrointestinal diseases by six native groups living in Sonora, Mexico, were evaluated against four enteropathogenic bacteria: Salmonella typhimorium (ATCC14028), Shigella flexneri (ATCC 12022), Escherichia coli (ATCC 25922), Escherichia coli (ATCC 35218). The antimicrobial activity was determined using the standard Disk Diffusion Method (DDM) protocol, and assessed by the presence or absence of inhibition zones. Fifteen methanol and four hexane crude extracts had activity against at least one strain. Methanol extracts from Acacia constricta Benth (Mimosaceae), Lysiloma divaricata J.F. MacBride (Fabaceae), Lysiloma watsonii Rose (Fabaceae), and Pithecellobium dulce (Roxb.) Benth (Fabaceae) showed activity against all evaluated enteropathogenic bacteria. The methanol extract of Struthanthus haenkeanus Standley (Loranthaceae) had strong antimicrobial activity against S. flexneri. Only Coursetia glandulosa Gray (gum) (Fabaceae) and Mascagnia macroptera Niedensu (Malpighiaceae) hexane extracts had activity against enterophatogenic bacteria. This is the first evaluation of these medicinal plants against bacterial pathogens that cause gastrointestinal disorders, such as diarrhea and dysentery in the Mexican population.

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Section: Resultscontrasting

confidence: 99%

Section: Resultsmentioning

confidence: 94%

Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Salazar

Verdugo

López

et al. 2008

Pharmaceutical Biology

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“…camara (roots) Pan et al (1993b) hederagenin (20), 25-hydroxy-3-oxoolean-12-en-28-oic acid (21) Singh et al (1996) 21,22β-epoxy-3β-hydroxyolean-12-en-28-oic methyl ester (22) Misra & Laatsch (2000) camarin (23), lantanone (24) L. camara (leaves) Begum et al (2006Begum et al ( , 2008b 22β-tigloyloxylantanolic acid (25) camarilic acid (26) L. camara (aerial parts) Begum et al (1995) L. camara (roots) Misra & Laatsch (2000) 19α-hydroxy ursolic (42), lantaiursolic acid (43) Pan et al (1993b) ursonic acid (44) L. camara (aerial parts) Begum et al (1995) lantacin (45) Begum et al (2006Begum et al ( , 2008b Singh et al (1990) 24-hydroxy-3-oxours-12-en-28-oic acid (48) L. trifolia (leaves) Rwangabo et al (1988) 3,24-dioxo-urs-12-en-28-oic acid (49) L. camara (leaves) Yadav & Tripathi (2003) α-amyrin (50) L. camara (leaves, flowers and stems) Ahmed et al (1972a;1972b) methyl 3-oxours-late (51) L. camara (leaves) Barua et al (1969) methyl-24-hydroxy-3-oxoursolate (52) L. indica (aerial parts) Singh et al (1989a) camaranoic acid (53) L. camara (aerial parts) Begum et al (2008a) lantoic acid (54) Begum et al (2008b); Roy & Barua (1985) camarinic acid (55) L. camara (leaves, 1 stems 2 ) Siddiqui et al (1995) 1 ; Barre et al (1997) 1 ; Saleh et al (1999) …”

Section: Triterpenoidsmentioning

confidence: 99%

“…By comparison, chloramphenicol against S. aureus and tetracycline against S. typhi had an index of respectively 1.6 and 0.8 at the same concentration (Barre et al, 1997). Rwangabo et al (1988) reported that umuhengerin (90) …”

Section: Antibacterial Antifungal Activitymentioning

confidence: 99%

Genus Lantana: chemical aspects and biological activities

Sousa¹,

Costa²

2012

Rev. bras. farmacogn.

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Species of the genus Lantana, belonging to the family Verbenaceae, is among the various species studied scientifically. These species are mainly native to the tropical and subtropical regions of the Americas. Currently, they are present in various countries, where they are often grown as ornamental plants. For decades, species of Lantana have been of great interest for phytochemical, biological and pharmacological studies, which have been recently intensified. The components isolated from different species of Lantana cited in the literature constitute the focus of this review. Information ethnopharmacology of Lantana, as well as the activities of their different phytochemicals are discussed. In this review, it was observed that the genus Lantana has been widely studied in relation to its phytochemical components and terpenoids, flavonoids and phenylpropanoids are the more common secondary metabolites in Lantana. All these aspects, considered in this review, allow an evaluation of the ethnopharmacological potential of Lantana for the utilization of the large biomass of these plants.

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“…Two active toxic principles -lantadene α and β-are considered the most important, and both target the liver. In addition to lantadenes α and β, previous reports showed that the plant produces other triterpenes of the lantadene type, such as lantanolic acid, lantic acid, 22-b-dimethylacryloyloxylantanolic acid, a mixture of 22-b-dimethylacryloyloxylantanolic acid and 22-b-angeloyloxylantanolic acid, and lantanolic acid (Barre et al, 1997). The presence of flavonoids, iridoids, oligosaccharides, phenylpropanoids glycosides, and naphthoquinones has been reported (Sharma et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of Lantana camara L. extract in mice

Silva

Suffredini

Ricci

et al. 2015

Rev. bras. plantas med.

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he Lantana camara L. belongs to the family Verbenaceae, which contains several active compounds in leaves and roots and which are reported to have medicinal and insecticidal properties. Studies of plants within the same family show the existence of anti-inflammatory activity in paw edema induced by carrageenan, serotonin and histamine and analgesic activity in the acetic acid writhing and tail-flick tests. The present study investigated whether the L. camara extract (ACE) also exerts these effects. The ACE toxicity was studied in male mice, and the percentage of mortality recorded 7 days after treatment was assessed. The ACE was evaluated as an antinociceptive agent in the hot plate, tail-flick and acetic acid writhing tests at a nontoxic dose of 1.0 g/Kg. The results showed that 1.5 g/Kg of ACE was not able to cause death, and doses of 3.0 and 4.0 g/Kg caused 50% and 60% death, respectively, in male mice. In all of the antinociceptive tests, 1 g/Kg of ACE markedly reduced responses to pain. Our findings suggest that ACE may have active anti-inflammatory and antinociceptive properties in much smaller doses than toxic.Keywords: Lantana camara, hot plate test, tail-flick test, acetic acid writhing test, mice. RESUMO: Efeitos antinociceptivos do extrato de Lantana camara L. em camundongos.Lantana camara L. pertence à família Verbenaceae, a qual contem muitos princípios ativos em suas folhas e raízes com propriedade medicinais e inseticidas. Estudos com plantas da mesma família mostram a existência de propriedades antinflamatórias no modelo de edema de pata induzido pela carragenina, serotonina e histamina, além da atividade analgésica nos testes de contorção induzida pelo ácido acético e da retirada da cauda por estímulo térmico. O presente trabalho investigou os efeitos tóxicos e antinociceptivos do extrato de L. camara (ACE) em camundongos. Para tanto, investigou-se a porcentagem de mortes em 7 dias após a administração de diferentes doses do extrato. Avaliou-se também os efeitos antinociceptivos do ACE pelos testes da placa quente, estimulação térmica da cauda e contorções abdominais induzidas pelo ácido acético com a dose não-tóxica [1,0 g/Kg]. Os resultados mostraram que 1,5 g/Kg do ACE não causou mortalidade, enquanto que 3,0 e 4,0 g/Kg promoveram 50 e 60% de mortalidade, respectivamente. Em todos os testes antinociceptivos, a dose de 1,0 g/ Kg do ACE reduziu a resposta à dor. Os presentes resultados indicam que o ACE apresenta propriedades antinflamatórias e analgésicas em doses muito menores que a tóxica.Palavras chaves: Lantana camara L., teste da placa quente, estímulo térmico na cauda, teste de contorções abdominais, camundongos.

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A bioactive triterpene from Lantana camara

Cited by 113 publications

References 3 publications

Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Activity of Medicinal Plants, Used by Native Populations from Sonora, Mexico, Against Enteropathogenic Bacteria

Genus Lantana: chemical aspects and biological activities

Antinociceptive and anti-inflammatory effects of Lantana camara L. extract in mice

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