Antinociceptive and anti-inflammatory effects of Lantana camara L. extract in mice

Abstract

he Lantana camara L. belongs to the family Verbenaceae, which contains several active compounds in leaves and roots and which are reported to have medicinal and insecticidal properties. Studies of plants within the same family show the existence of anti-inflammatory activity in paw edema induced by carrageenan, serotonin and histamine and analgesic activity in the acetic acid writhing and tail-flick tests. The present study investigated whether the L. camara extract (ACE) also exerts these effects. The ACE toxicity was studied in male mice, and the percentage of mortality recorded 7 days after treatment was assessed. The ACE was evaluated as an antinociceptive agent in the hot plate, tail-flick and acetic acid writhing tests at a nontoxic dose of 1.0 g/Kg. The results showed that 1.5 g/Kg of ACE was not able to cause death, and doses of 3.0 and 4.0 g/Kg caused 50% and 60% death, respectively, in male mice. In all of the antinociceptive tests, 1 g/Kg of ACE markedly reduced responses to pain. Our findings suggest that ACE may have active anti-inflammatory and antinociceptive properties in much smaller doses than toxic.Keywords: Lantana camara, hot plate test, tail-flick test, acetic acid writhing test, mice. RESUMO: Efeitos antinociceptivos do extrato de Lantana camara L. em camundongos.Lantana camara L. pertence à família Verbenaceae, a qual contem muitos princípios ativos em suas folhas e raízes com propriedade medicinais e inseticidas. Estudos com plantas da mesma família mostram a existência de propriedades antinflamatórias no modelo de edema de pata induzido pela carragenina, serotonina e histamina, além da atividade analgésica nos testes de contorção induzida pelo ácido acético e da retirada da cauda por estímulo térmico. O presente trabalho investigou os efeitos tóxicos e antinociceptivos do extrato de L. camara (ACE) em camundongos. Para tanto, investigou-se a porcentagem de mortes em 7 dias após a administração de diferentes doses do extrato. Avaliou-se também os efeitos antinociceptivos do ACE pelos testes da placa quente, estimulação térmica da cauda e contorções abdominais induzidas pelo ácido acético com a dose não-tóxica [1,0 g/Kg]. Os resultados mostraram que 1,5 g/Kg do ACE não causou mortalidade, enquanto que 3,0 e 4,0 g/Kg promoveram 50 e 60% de mortalidade, respectivamente. Em todos os testes antinociceptivos, a dose de 1,0 g/ Kg do ACE reduziu a resposta à dor. Os presentes resultados indicam que o ACE apresenta propriedades antinflamatórias e analgésicas em doses muito menores que a tóxica.Palavras chaves: Lantana camara L., teste da placa quente, estímulo térmico na cauda, teste de contorções abdominais, camundongos.

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

“…However, it is also possible that some other compounds interact synergistically or antagonistically. The anti-inflammatory activity of L. camara extracts has previously been demonstrated in several studies [12,[74][75][76]. However, IC 50 values were lower than 17.75 µg/mL in the present study (IC 50 of L. camara essential oil from Peru was 81.5 µg/mL [7]), indicating that L. camara is a plant with anti-inflammatory properties in various forms, supporting the wide use of this plant in traditional medicine for its anti-rheumatism properties [5].…”

Evaluation of the antidiarrhoeal activity of 80% methanol extract and solvent fractions of the leaves of <i>Lantana camara</i> linn (Verbenaceae) in mice

“…antioxidant (Rabia and Asghari, 2013), wound healing (Mahmood et al, 2009), antimotility (Sagar et al, 2005), antinociceptive and anti-inflammatory (Silva et al, 2015), antimalarial (Gabi et al, 2011), antiulcerogenic (Sathish et al, 2011),…”

Evaluation of the anti-diarrheal activity of the aqueous stem extract of Lantana camara Linn (Verbenaceae) in mice

“…Ethnopharmacological studies revealed that L. camara has been proven to have activities against that diarrhoea causing microorganisms including antibacterial [16], antifungal [17] and anthelmintic [18] activities. In addition, it also possess antimycobacterial [19], antioxidant [20], antinociceptive & anti-inflammatory [21], antimalarial [22], antiulcerogenic [23], and anti-leishmaniasis [24] activities. In vivo studies, indicate the leaves of L.camara and, its constituents (Lanthadne A) have antimotility [13] and antidiarrheal activity in mice model of diarrhoea [14].…”