A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid

Qin, Junyuan; Zeng, Li; Wei, Min; Tan, Licheng; Lv, Ruizhi; Chen, Yiwang

doi:10.1016/j.coco.2019.04.002

Cited by 8 publications

(10 citation statements)

References 24 publications

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“…The positive performance of the novel PAP+ gel adds to previous evidence from in vitro and clinical studies supporting the use of PAP in bleaching gels as a safe and effective alternative in OTC products to HP and CP [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 69%

“…A more recent laboratory study published in 2019 compared a PAP-based gel against a conventional HP gel. While both had similar bleaching effects on bovine teeth, surface morphology and hardness measurements of the bleached teeth revealed that the HP gel caused some reduction in surface microhardness, while the PAP-based gel did not affect the integrity of enamel [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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A Radical-Free Approach to Teeth Whitening

Pascolutti¹,

Oliveira²

2021

Dentistry Journal

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Background: Traditional bleaching agents based on hydrogen peroxide (HP) or carbamide peroxide (CP) have adverse soft and hard tissue effects. Objectives: This study tested a novel formulation of phthalimidoperoxycaproic acid (PAP) with additives to optimise its safety and effectiveness. Methods: A novel gel (PAP+) was formulated. Laboratory studies assessed effects of six 10-minute exposures to PAP+ vs. commercial CP and HP gels, using surface profilometry and microhardness. The effectiveness of PAP+ in vitro against complex polyphenol stains on enamel was compared to 6% HP. Results: Unlike HP gels, PAP+ gel did not erode enamel. Unlike both CP and HP gels, PAP+ gel did not reduce the surface microhardness of enamel. PAP+ gel on used on polyphenol stains was superior to 6% HP. In this model, six repeated 10-minute treatments with PAP+ gel could improve the shade by approximately eight VITA® Bleachedguide shades. Conclusions: These laboratory results support the safety and effectiveness of this new PAP formula and its use as an alternative to CP and HP with superior safety and effectiveness.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

A Radical-Free Approach to Teeth Whitening

Pascolutti¹,

Oliveira²

2021

Dentistry Journal

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“…Diante da eficácia cientificamente comprovada do clareamento dental, a técnica precedente às restaurações estéticas permite um resultado favorável, visto que aumenta o valor e o brilho do esmalte, acentuando as características de translucidez, também diminuindo a quantidade de desgastes do substrato dentário necessárias para a restauração final 2, [27][28][29][30] . No presente trabalho, optou-se pelo clareamento caseiro, supervisionado pelo cirurgião-dentista, com peróxido de carbamida 20%, visando não só realizar as restaurações finais com os dentes mais claros, mas minimizar os desconfortos possíveis frente ao agente clareador e potencializar os resultados do tratamento restaurador 31,32 .…”

Section: Discussionunclassified

Restauração estética de dentes conóides associada a recontorno gengival em paciente jovem: relato de caso

Oliveira

Miguel²,

Magalhães³

2021

Rev Odontol Bras Central

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A busca por tratamentos dentários por razões estéticas tem aumentado muito devido ao grande impacto do sorriso na autoestima e bem-estar dos pacientes em seu convívio social. No planejamento estético reabilitador critérios dento-faciais, labiais, periodontais e pessoais devem ser levados em consideração na indicação de qualquer tratamento. O objetivo deste artigo é relatar um caso de sorriso gengival e dentes conóides em paciente jovem, tratada com uma abordagem minimamente invasiva. No exame físico foi possível observar o sorriso gengival causado pela erupção passiva alterada e microdontia isolada nos incisivos laterais superiores, o que prejudicava a harmonia do sorriso. Foram propostos alguns planos de tratamento e diante do custo-benefício foram realizados aumento de coroa clínica estético sem retalho (“flapless”) dos incisivos centrais e laterais, e pré molares do lado direito superior, associada a clareamento dental caseiro supervisionado e restaurações diretas em resina composta sem preparo prévio da estrutura dentária. As restaurações foram guiadas por uma matriz de silicone obtida imediatamente e desgastada no tamanho final planejado com broca, sem a necessidade de enceramento diagnóstico. O resultado obtido com o tratamento proposto melhorou as proporções dento-faciais e gengivais, solucionando a queixa principal da paciente com preservação de estrutura dental sadia, restabelecendo estética e mantendo a função de forma adequada.

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“…Vital tooth bleaching may lead to sensitivity and mucosal burns [ 5 ]. Moreover, studies on human and bovine teeth have revealed alterations in surface microhardness, surface morphology, and the composition of teeth [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…For this, the bleaching material is loaded in the tray, and the patient is prescribed to wear the tray with material for seven hours daily for two weeks [ 2 ]. Other agents that are used or under research include blue covarine (organic pigment in water/glycerine), peroxy caproic acid, alumina, calcium carbonate and silica particles, sodium perborate, baking soda, peroxides, phosphate salts, and enzymes [ 5 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Investigation of Novel Ionic Liquid-Based Tooth Bleaching Gels: A Step towards Safer and Cost-Effective Cosmetic Dentistry

et al. 2023

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The objective of this study was to synthesize a novel choline hydroxide ionic liquid-based tooth bleaching gel. Ionic liquid-based gels were synthesized and characterized using FTIR along with pH testing. Tooth sample preparation was carried out in line with ISO 28399:2020. The effects of synthesized gels on tooth samples were tested. Tooth samples were stained and grouped into three experimental groups: EAI (22% choline hydroxide gel), EAII (44% choline hydroxide gel), and EB (choline citrate gel) and two control groups: CA (commercial at-home 16% carbamide peroxide gel) and CB (deionized water). The tooth color analysis, which included shade matching with the Vitapan shade guide (n = 2), and digital colorimetric analysis (n = 2) were evaluated. The surface characteristics and hardness were analyzed with 3D optical profilometry, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), and Microhardness testing (n = 3), respectively. The tooth color analysis (Vitapan shade guide) revealed that all the tooth samples treated with synthesized choline citrate gel (EB) showed an A1 shade as compared to the other four groups, giving a range of shades. An analysis of the ΔE values from digital colorimetry; EAI, EAII, CA, and CB showed ΔE values in a range that was clinically perceptible at a glance. However, EB showed the highest value of ΔE. The mean microhardness values for the five groups showed that the effects of three experimental gels i.e., 44% choline hydroxide, 22% choline hydroxide, and choline citrate, on the microhardness of the tooth samples were similar to that of the positive control, which comprised commercial at-home 16% carbamide peroxide gel. SEM with EDX of three tested subgroups was closely related in surface profile, elemental composition, and Ca/P ratio. The roughness average values from optical profilometry of four tested subgroups lie within approximately a similar range, showing a statistically insignificant difference (p > 0.05) between the tested subgroups. The synthesized novel experimental tooth bleaching gels displayed similar tooth bleaching actions without any deleterious effects on the surface characteristics and microhardness of the treated tooth samples when compared with the commercial at-home tooth bleaching gel.

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A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid

Cited by 8 publications

References 24 publications

A Radical-Free Approach to Teeth Whitening

A Radical-Free Approach to Teeth Whitening

Restauração estética de dentes conóides associada a recontorno gengival em paciente jovem: relato de caso

Synthesis, Characterization, and Investigation of Novel Ionic Liquid-Based Tooth Bleaching Gels: A Step towards Safer and Cost-Effective Cosmetic Dentistry

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