A Bifunctional Scaffold for Tissue Regeneration and Photothermal Therapy

Wang, Gang; Wu, Xiao Ming; Cen, Dong; He, Hong; Fu, Yongjian; Ren, Zhaohui; Wang, Yifan; Cai, X; Li, Xiang; Han, Gaorong

doi:10.1166/jbn.2018.2548

Cited by 11 publications

(5 citation statements)

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“…Particle-containing bifunctional hybrid scaffolds are the desired design for bone tumor therapy. [105][106][107] Microspheres composed of calcium phosphate-phosphorylated adenosine were prepared with high doxorubicin (DOX) loading for bone tumor therapy. 108 The pH-sensitive properties of microspheres presented a positive therapeutic effect on subcutaneous 143B osteosarcoma tumors in rats.…”

Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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Bone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

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Section: A New Strategy For Tumor Therapy and Bone Regenerationmentioning

confidence: 99%

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

et al. 2021

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“…Tellurite and germanate HMO glasses have been identified as good glass hosts also for metal or semiconductor nanoparticles (NPs) with the objective to enhance their optical properties provided by the surface plasmon resonance (SPR) mechanism [ 21 , 22 ]. Applications have been found for these nanoparticle/glass structures in photothermal therapy [ 23 ], medical sensing of antibodies [ 24 ], and Raman spectroscopy [ 25 ], just to cite several examples. Metallic NPs containing HMO glasses are also promising materials for use in nonlinear optical devices, as the NPs can also be used to enhance the linear and nonlinear properties of the glasses [ 26 , 27 ].…”

Section: Description Of the Tellurite And Germanate Glassesmentioning

confidence: 99%

Radiation-Induced Defects and Effects in Germanate and Tellurite Glasses

et al. 2020

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This review focuses on the radiation-induced changes in germanate and tellurite glasses. These glasses have been of great interest due to their remarkable potential for photonics, in terms of extended transmission window in the mid-infrared, ability of rare-earth loading suitable with a laser, and amplification in the near- and mid-infrared or high nonlinear optical properties. Here, we summarize information about possible radiation-induced defects, mechanisms of their formation, and the influence of the glass composition on this process. Special attention is paid to laser-induced structural modification of these glasses, including possible mechanisms of the laser-glass interaction, laser-induced crystallization, and waveguide writing. It is shown that these methods can be used for photostructuring of the glass and have great potential for practical applications.

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“…Hyperthermal reagents such as iron oxide nanopartciles, gold nanoperticles, carbon nanotubes, graphene, ceramic nanoparticles and polydopamine have been incorporated in biocompatible and biodegradable polymers and bioceramics to generate multifunctional scaffolds for hyperthermal cancer therapy and tissue engineering [1][2][3][4][5][6][7][8][9][10][11][12]. Composite porous scaffolds of iron oxide (Fe 3 O 4 ) nanoparticles have been prepared by incorporating them into gelatin porous matrices [1].…”

Section: Photothermal Tumor Ablationmentioning

confidence: 99%

“…As a new strategy, combination of some of the methods has been proposed by using multi-functional therapeutic scaffolds for cancer therapy [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Photothermal nanoparticles and reagents have been incorporated in porous scaffolds of biodegradable materials to form multi-functional scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Multi-Functional Composite Scaffolds for Cancer Therapy and Tissue Engineering

Chen

2019

BJSTR

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Eradication of remaining and metastatic cancer cells to protect cancer recurrence remains a challenge for cancer therapy. Meanwhile regeneration of large defect after surgical resection is desirable for improving the quality of life of the patients. In recent years, multi-functional composite scaffolds with both excellent ablation effect on cancer cells and promotive effect on tissue regeneration have been reported for simultaneous cancer therapy and tissue engineering. Photothermal conversion nanoparticles and reagents have been hybridized with biocompatible polymers or bioceramics to generate the multi-functional photothermal scaffolds. Photothermal ablation, activation of immune cells and promotive tissue regeneration have been demonstrated by in vitro cell culture and in vivo animal experiments. The review summarizes the latest developments of these multi-functional composite scaffolds.

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A Bifunctional Scaffold for Tissue Regeneration and Photothermal Therapy

Cited by 11 publications

References 0 publications

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Radiation-Induced Defects and Effects in Germanate and Tellurite Glasses

Multi-Functional Composite Scaffolds for Cancer Therapy and Tissue Engineering

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