A Bibliometric and Visualized Analysis of Uremic Cardiomyopathy From 1990 to 2021

Abstract

BackgroundUremic cardiomyopathy is commonly presented in chronic kidney disease (CKD), and it severely affects the prognosis of patients with CKD. In the past few decades, the investigation of uremic cardiomyopathy has developed rapidly. However, no report has summarized the situation of uremic cardiomyopathy research to date. This study aimed to evaluate the state of uremic cardiomyopathy research in the last 30 years and identify important topics and achievements, as well as emerging trends through bibliometric analysis.Materials and MethodsPublications related to uremic cardiomyopathy were collected from Science Citation Index Expanded. HistCite, VOSviewer, CiteSpace, and the Bibliometrix Package were used for bibliometric analysis and visualization, including the analysis of the overall distribution of the annual publication, leading countries, and active institutions and authors, core journals, co-cited references, and keywords.ResultsA total of 2,403 studies related to uremic cardiomyopathy were obtained, and progress related to uremic cardiomyopathy was slower in past 3 years. A total of 10,077 authors from 2,697 institutions in 89 countries or regions reported investigations on uremic cardiomyopathy. The United States of America was the most productive and the most cited country. Myles Wolf, Joseph I Shapiro, and Carmine Zoccali published most articles in uremic cardiomyopathy, and journals in nephrology possessed core status in the field. Phosphate metabolism was the hotspot in uremic cardiomyopathy research in recent years, and future progress may concentrate on phosphate metabolism, endogenous natriuretic factors, and novel biomarkers.ConclusionThe United States of America and European countries played central roles in uremic cardiomyopathy research, while Chinese scholars should be more involved in this field. Global publications on uremic cardiomyopathy have entered platform stage, and the fibroblast growth factor-23-klotho axis remained a hotspot in this field. Endogenous natriuretic factors and novel biomarkers may be potential directions in future investigations.

Emerging trends and hotspots evolution in cardiotoxicity: A bibliometric and knowledge-Map analysis From 2010 to 2022

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Associations of Traditionally Determined Left Ventricular Mass Indices and Hemodynamic and Non-Hemodynamic Components of Cardiac Remodeling with Diastolic and Systolic Function in Patients with Chronic Kidney Disease

“…Uremic cardiomyopathy comprises diastolic dysfunction, underlying fibrosis and left ventricular hypertrophy [ 2 , 3 ]. The pathophysiological mechanisms that link chronic kidney disease with uremic cardiomyopathy include increased pre-load mediated by volume overload and anaemia and increased afterload due to arteriosclerosis and hypertension, as well as a wide range of biochemical factors, including chronic kidney disease bone and mineral disorder, renin–angiotensin–aldosterone and sympathetic nervous system overactivity, transforming growth-β, uremic toxins and endogenous cardiotonic steroids [ 1 , 2 , 3 , 4 ]. Diastolic dysfunction that can lead to heart failure with preserved ejection fraction is the most prevalent cardiac function abnormality in patients with chronic kidney disease [ 5 ].…”

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