Associations of Traditionally Determined Left Ventricular Mass Indices and Hemodynamic and Non-Hemodynamic Components of Cardiac Remodeling with Diastolic and Systolic Function in Patients with Chronic Kidney Disease

Hsu, Hon-Chun; Tade, Grace; Robinson, Chanel; Dlongolo, Noluntu; Teckie, Gloria; Solomon, Ahmed; Woodiwiss, Angela J.; Dessein, Patrick H

doi:10.3390/jcm12134211

Cited by 1 publication

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“…Each patient provided informed written consent prior to participation. The study design was reported previously ( 28 – 30 ). One hundred and fifteen patients participated.…”

Section: Methodsmentioning

confidence: 99%

“…Methods that were employed in this study have been reported previously ( 28 – 30 ). Recorded baseline characteristics comprised demographic features, anthropometric measures, major traditional cardiovascular risk factors, non-traditional or renal cardiovascular risk factors and the use of cardiovascular drugs and erythropoietin stimulating agents.…”

Section: Methodsmentioning

confidence: 99%

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The relative potential contribution of volume load and vascular mechanisms to hypertension in non-dialysis and dialysis chronic kidney disease patients

Tade,

Hsu,

Robinson

et al. 2024

Front. Cardiovasc. Med.

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BackgroundHypertension is highly prevalent and particularly difficult to treat adequately in patients with chronic kidney disease (CKD). The relative contribution of volume overload and vascular mechanisms to blood pressure measures in CKD and whether these effects differ in non-dialysis compared to dialysis patients is unknown.MethodsWe determined the potential impact of volume load (stroke volume) and vascular mechanisms (inverse of total arterial compliance (inv TAC) and systemic vascular resistance (SVR)) on mean and brachial and aortic systolic blood pressures in 67 non-dialysis and 48 dialysis chronic kidney disease (CKD) patients. Relationships were determined in confounder adjusted regression models.ResultsStroke volume (p value = 0.003) was more strongly associated with mean arterial pressure than SVR (p value = 0.9) (p value for difference = 0.03). When stroke volume and SVR were entered in the same regression model (model R2 = 0.324), they contributed equally to the variation in mean arterial pressure (p value for difference = 0.5). Stroke volume (p value ≤ 0.002) and inv TAC (p value ≤ 0.001) contributed equally to the variation in systolic pressures (p value for difference ≥ 0.9). When stroke volume and inv TAC were entered in the same regression model (model R2 = 0.752 to 0.765), they contributed equally to the variation in systolic blood pressures (p value for difference = 0.7). Stroke volume, TAC and SVR were similar (p value ≥ 0.5) and associated to the same extent with blood pressure measures in non-dialysis and dialysis CKD patients (p value for difference ≥ 0.1). In receiver operator characteristic curve analysis, elevated systolic blood pressure was determined by stroke volume (p value = 0.005) and inv TAC (p value = 0.03) but not SVR (p value = 0.8). The calculated power of the study was 0.999 based on α = 0.05.ConclusionsThe present investigation suggests that both volume load and vascular mechanisms should be considered in the management of hypertension among patients with CKD. The extent and relative potential impact of volume load and vascular mechanisms on blood pressure measures are as large in non-dialysis compared to dialysis CKD patients.

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“…Each patient provided informed written consent prior to participation. The study design was reported previously ( 28 – 30 ). One hundred and fifteen patients participated.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%