A bibliometric analysis of the application of stem cells in glaucoma research from 1999 to 2022

Abstract

Background: Glaucoma, a neurodegenerative disease of the retina, is the leading cause of irreversible blindness. Stem cells have therapeutic potential for glaucoma. However, few bibliometric studies have been published in this field. Concerning a visual map, this article aims to characterize the research context, cooperation relationship, hotspots, and trends concerning the application of stem cells in glaucoma research.Methods: Publications focusing on stem cell research and glaucoma were retrieved from the Web of Science Core Collection. VOSviewer, CiteSpace, Microsoft Excel, and Scimago Graphica were used to map the contributions of countries or regions, authors, organizations, and journals. Journal Impact Factor data were obtained from the Web of Science Core Collection. We analyzed the tendencies, hotspots, and knowledge networks using VOSviewer, and CiteSpace.Results: We analyzed 518 articles published from 1999 through 2022. In the first decade, the number of articles in this field increased slowly, and there was a marked acceleration in publication frequency after 2010. The United States, China, and England were the main contributors. Yiqin Du was the most prolific author, and among the top 10 prolific writers, Keith R. Martin’s work was cited most frequently. Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Cornea published the most articles in this domain. The three most commonly co-cited journals were Investigative Ophthalmology and Visual Science, Experimental Eye Research, and Proceedings of the National Academy of Sciences of the United States of America. The Central South University, the University of Pittsburgh, and the National Institutes of Health National Eye Institute were highly prolific institutions in this research area. Our keywords analysis with VOSviewer suggested directions of future research and yielded the following recent key themes, extracellular vesicles, exosomes, mitochondria, growth factors, oxidative stress, and ocular diseases. Four co-cited references had a citation burst duration until 2022.Conclusion: With improvements in overall quality of life and demographic transitions toward population aging, research and clinical focus on eye care has increased, with glaucoma as a key area of emphasis. This study added to our understanding of the global landscape and Frontier hotspots in this field.

Publication trends of primary angle-closure disease during 1991-2022: a bibliometric analysis

“…Therefore, using "primary angle-closure" as the search topic can accurately target all relevant publications regarding to PACD. Previous bibliometric analysis have focused on glaucoma [21][22][23] , POAG [31] , application of stem cells in glaucoma [32] . As far as we know, this is the first bibliometric analysis regarding to PACD.…”

The Application of MicroRNAs in Glaucoma Research: A Bibliometric and Visualized Analysis

“…Next, we obtained the research hotpots and trends by analyzing the co-occurrence of keywords [24]. This bibliometric information was analyzed by VOSviewer as follows: there were 1040 keywords in total, of which 59 appeared a minimum of five times, with a total of five clusters (Figure 6A).…”

“…Bibliometric analysis is a commonly used scientific and quantitative research approach for publications, which includes collecting, processing, and managing the data from previous scientific publications to summarize the advancements in research topics and analyze the contributions of authors, institutions, journals, and countries or regions [22,23]. In addition, bibliometric analysis can identify hotspots, emerging tendencies, and knowledge networks in a particular field [24]. However, there are minimal studies available that have applied a bibliometric analysis to the field of miRNAs in glaucoma.…”

ANALYSIS OF GLOBAL RESEARCH TRENDS IN THE INTERNET OF THINGS (IoT) AREA WITH NETWORK MAP TECHNIQUE

“…VOSviewer was used to perform co-occurrence analyses and create visualized collaboration network maps for countries/regions, institutions, and authors. The software has been used in various fields, including health sciences and social sciences, especially for displaying large bibliometric maps in an easily interpretable manner (Ling, 2022; Pradhan and Samanta, 2022;Song, 2023;Tao, 2023). The figure above shows a network visualization map of the most cited researchers in IoT studies written in management and public administration.…”