A bi-faceted role of estrogen receptor β in breast cancer

Leygue, Etienne; Murphy, Leigh C.

doi:10.1530/erc-12-0389

Cited by 68 publications

(68 citation statements)

References 118 publications

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“…Previous results from this cohort suggested that the prognostic role of AR in breast cancer was dependent on the ERa status of the tumor (20). Similar hypotheses have been proposed for ERb (10), and an in vitro study suggested ERb to be the link between AR and ERa interactions (28). However, in the current study, unlike AR, ERb1 75 þ was prognostically beneficial irrespective of ERa expression.…”

Section: Discussionsupporting

confidence: 82%

“…One in vitro study reported that ERb agonists reduced cell invasion and the metastatic potential of TNBC (30). Also, new ways of directing ligands to nuclear hormone targets are under way (31), which was recently suggested as a future possibility for ERb targeting (10).…”

Section: Discussionmentioning

confidence: 99%

“…Valid tumor ERb1 scores were obtained from 911 patients (88.8% 10 expression was not significantly associated with the four germline ERb htSNPs or the two haplotypes "any TCAC" or the number of CCGC, either overall or in patients with BMI !25 kg/m 2 , where two htSNPs and the two haplotypes were differently associated with DFS depending on BMI in our previous report (3).…”

Section: Patient and Tumor Characteristics By Erb1 Statusmentioning

confidence: 99%

“…Contrasting findings of ERb-driven proliferative effects, foremost in ERa À tumors, have suggested a differential role for ERb, depending on breast cancer subtype (9,10). As the results from clinical studies have been inconsistent, large prospective trials that examine isoform-specific ERb expression stratified by ERa status have been called for (5).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

High Estrogen Receptor β Expression Is Prognostic among Adjuvant Chemotherapy–Treated Patients—Results from a Population-Based Breast Cancer Cohort

Elebro

Borgquist

Rosendahl

et al. 2017

Clinical Cancer Research

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Purpose: Isoform-specific tumor estrogen receptor b (ERb) expression may hold prognostic information in breast cancer, especially among endocrine-treated breast cancer patients. The study's purpose was to evaluate ERb isoform 1 (ERb1) expression in relation to tumor characteristics, ESR2 genotypes, and prognosis in different treatment groups.Experimental Design: A population-based prospective cohort of 1,026 patients diagnosed with primary invasive breast cancer in Lund, Sweden, between October 2002 and June 2012 was followed until June 2014 (median 5 years). Associations between immunohistochemical ERb1 expression, patient and tumor characteristics, as well as outcome within treatment groups were analyzed.Results: Tumor ERb1 expression was available for 911 patients (89%) and was not associated with ESR2 genotypes. ERb1 positivity, defined as >75% ( ERb1 75

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Patient and Tumor Characteristics By Erb1 Statusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High Estrogen Receptor β Expression Is Prognostic among Adjuvant Chemotherapy–Treated Patients—Results from a Population-Based Breast Cancer Cohort

Elebro

Borgquist

Rosendahl

et al. 2017

Clinical Cancer Research

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“…For this reason, the role of ERb in the development and progression of breast cancer has been defined as ''bi-faceted''. Therefore, selective ERb ligands could help in shedding light on this issue, by broadening the molecular understanding of the involvement of ERb in this kind of tumor, but they also might represent a valid alternative to its canonic ERa-targeted therapeutic treatments 8,9 . Finally, very recently ERb proved to have a deep impact in neuroinflammation, by promoting neuroprotecting effects in oligodendrocytes.…”

Section: Introductionmentioning

confidence: 99%

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

Tuccinardi

Poli

Dell'Agnello

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this paper, a receptor-based virtual screening study for the identification of estrogen receptor b (ERb) ligands was developed. Starting from a commercial database of 400 000 molecules, only six compounds resulted to be potential active ligands of ERb. Interestingly, all the six molecules possess scaffolds that had already been reported in known ERb ligands. Therefore, the results obtained herein confirm the reliability of our virtual screening procedure, thus encouraging the application of this protocol to larger commercial databases in order to identify new ERb ligands.

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miR‐191/DAB2 axis regulates the tumorigenicity of estrogen receptor‐positive breast cancer

Tian

Zhang

2017

IUBMB Life

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Disabled-2 (DAB2) has been shown to be downregulated in a variety of human cancer types including breast tumors. However, the role of DAB2 in estrogen receptor positive (ER+) breast cancer cells has not been reported. In this context, we demonstrated that DAB2 expression was significantly decreased in ER+ breast cancer cell lines and ER+ clinical specimens, compared with ER- breast cancer cell lines and ER- tissues, respectively. Depletion of estrogen significantly elevated DAB2 expression in ER+ MCF7 and T-47D cells. Treatment with estradiol (E2) reduced the expression of DAB2 and administration of tamoxifen upregulated DAB2 expression in a dose-dependent manner. Functionally, silencing of DAB2 in hormone-starved MCF7 and T-47D cells promoted cellular proliferation and enforced expression of DAB2 in normal-cultured or E2-treated cells suppressed cellular proliferation. Mechanistically, estrogen-induced miR-191 was identified as a direct upstream regulator of DAB2 in ER+ cells. Luciferase reporter assay indicated that miR-191 inhibited DAB2 expression by directly targeting the 3'-UTR of DAB2. Importantly, the expression and function of miR-191 showed the opposite tendency with DAB2 in ER+ cells. In vivo, inhibition of miR-191 significantly suppressed the xenograft growth induced by E2, and silencing of DAB2 could restored the growth arrest induced by miR-191 inhibition. Taken together, our data unveil that the miR-191-DAB2 axis seems to be an important pathway associated with estrogen signaling in breast cancer and may serve as a potential diagnostic biomarker and a powerful therapeutic target for ER+ breast cancer patients. © 2017 IUBMB Life, 70(1):71-80, 2018.

show abstract

A bi-faceted role of estrogen receptor β in breast cancer

Cited by 68 publications

References 118 publications

High Estrogen Receptor β Expression Is Prognostic among Adjuvant Chemotherapy–Treated Patients—Results from a Population-Based Breast Cancer Cohort

High Estrogen Receptor β Expression Is Prognostic among Adjuvant Chemotherapy–Treated Patients—Results from a Population-Based Breast Cancer Cohort

Receptor-based virtual screening evaluation for the identification of estrogen receptorβligands

miR‐191/DAB2 axis regulates the tumorigenicity of estrogen receptor‐positive breast cancer

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