In this paper, a receptor-based virtual screening study for the identification of estrogen receptor b (ERb) ligands was developed. Starting from a commercial database of 400 000 molecules, only six compounds resulted to be potential active ligands of ERb. Interestingly, all the six molecules possess scaffolds that had already been reported in known ERb ligands. Therefore, the results obtained herein confirm the reliability of our virtual screening procedure, thus encouraging the application of this protocol to larger commercial databases in order to identify new ERb ligands.
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