A benign gonadal stromal tumor of the testis of spindle fibroblastic type

Allen, Philip R.; King, Alan R.; Sage, Martin; Sorrell, V. F.

doi:10.3109/00313029009086667

Cited by 18 publications

(13 citation statements)

References 6 publications

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“…In our case, the patient denied any infection or trauma in the area of the testicle which is consistent with the data from Deveci et al (3). With our patient, there was no pain in the testicle, increase in tumor markers or pathological findings in the analysis of blood and urine, the same as with Pinieux et al, Renshaw et al, and Allen et al (7,5,8). Only a small number of cases of TF grew rapidly and were accompanied by pain (2,3).…”

Section: Discussionsupporting

confidence: 94%

Testicular (gonadal stromal) fibroma: Case report

et al. 2012

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Testicular fibroma is a rare benign tumor of gradual growth, usually in the third and fourth decade, in the form of a hypoechogenous nodule with clear boundaries and is usually not accompanied by hormonal abnormalities. Metastasis and recurrence of disease were not noted. A 40-year-old male saught medical attention due to pain in the lower back that spread to the pubic bones and the groin. During physical examination, a painless nodule with clear boundaries was palpated in the right testicle, and the ultrasonographic examination revealed hypoechogenic zone with vague boundaries of about 10 mm in diameter. Standard biochemical analyses of blood and urine tests and tumor markers (CEA, CA 125, CA 19-9, AFP and βHCG) were within the physiological limit. Histopathologic analysis set a diagnosis of testicular fibroma. The absence of sex cords in the tumor tissue made it possible to diagnose the patient using standard staining methods, but in cases where these elements can be histologically verified, immunohistochemical analysis should be introduced into a routine diagnostic algorithm

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Section: Discussionsupporting

confidence: 94%

Testicular (gonadal stromal) fibroma: Case report

et al. 2012

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“…Intratesticular tumors such as hemangioma, leiomyoma, neurofibroma and fibroma of gonadal stroma are rare 1 . Very few cases of testicular gonadal stromal fibroma have been reported to date 2–12 . These lesions have previously been described under many different names such as unclassified sex cord–stromal tumor (SCST), spindle fibroblastic‐type benign gonadal stromal tumor, testicular stromal tumor with myofilaments, myoid gonadal stromal tumor with epithelial differentiation, testicular fibroma and, recently, fibroma of gonadal stromal origin.…”

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confidence: 99%

Testicular (gonadal stromal) fibroma: Case report and review of the literature

Deveci̇

Deveci

Öngürü

et al. 2002

Pathology International

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A 25-year-old man presented with complaint of a painless enlargement in his left testis. The solid, encapsulated, circumscribed and grayish-white testicular mass displayed the characteristics of testicular fibroma histologically. It was composed of acellular collagenized plaques and hypercellular areas of fibroblastic spindle cells. Immunohistochemically, the neoplastic cells were positive for vimentin and smooth muscle actin, but not for cytokeratin, S-100 protein, desmin, CD99/MIC2 (a protein expressed by Sertoli cells and granulosa cells) and CD34. Only 18 cases of testicular (gonadal stromal) fibroma composed exclusively of spindle cells have been reported to date. An additional case of fibroma, which lacks definite neoplastic sex cord elements, and its differential diagnosis from other mesenchymal lesions of testis are discussed here, together with other cases in the literature.

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“…1,2 Age at presentation ranges widely, between 5 and 69 years. 1,2 Age at presentation ranges widely, between 5 and 69 years.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10] There is some controversy on the nomenclature of these lesions. [1][2][3][4][5][6][7][8][9][10] There is some controversy on the nomenclature of these lesions.…”

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confidence: 99%

Testicular Fibrothecoma

Zhang¹,

Kao

Ulbright

et al. 2013

American Journal of Surgical Pathology

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Benign intratesticular spindle cell lesions are rare. Herein, we report the morphology, immunohistochemical characteristics, and prognosis of 16 cases of testicular fibrothecoma. The mean age at diagnosis was 44 years (16 to 69 y). Of 15 patients with information, 14 presented with a palpable testicular mass and 1 with heaviness in the scrotum. Medical histories included bilateral orchidopexy as a child (n=1) and testicular atrophy receiving testosterone replacement (n=1). The average size was 1.8 cm (median 2 cm; range, 0.5 to 7.6 cm). All cases were intratesticular, although 13 were abutting the tunica albuginea with others centered on the rete testis (n=2), or were indeterminate on biopsy (n=1). Eleven cases were relatively well circumscribed, although not encapsulated, with 1 being infiltrative and 4 not evaluable. Four tumors showed entrapment of seminiferous tubules. Half of the fibrothecomas showed a mixed storiform pattern and short fascicles, with 6 storiform only and 2 short fascicles only. One half of the tumors were very hypercellular. Cases were equally split between having plumper ovoid as opposed to spindled pointed nuclei, with all cases lacking prominent nucleoli. Eleven cases had 0 to 2 mitoses per 10 HPF, 3 had 4 to 5 mitoses per 10 HPF, and 2 had 9 to 10 mitoses per 10 HPF. Collagen deposition either in bands or investing single cells ranged from none to extensive, with 10/16 cases having at least a moderate amount. Immunohistochemical positivity was as follows: inhibin (11/13, patchy to diffuse); calretinin (5/9); Melan-A (4/4); pan keratin (5/8); BCL2 (3/4); CD34 (3/8); S100 (4/8); muscle-specific actin (4/4); and desmin (5/8). Patients were followed up for a mean of 71.8 months (range, 3 to 144 mo). All were well with no evidence of disease. Of the 2 men with 9 to 10 mitoses per 10 HPF, 1 died of other causes 5 years and 8 months later, and the other had no evidence of disease at 4 years and 10 months after surgery. In summary, testicular fibrothecomas are rare with somewhat variable histology and can have worrisome histologic features such as minimal invasion into surrounding testis, high cellularity, and increased mitotic rate. Their immunoprofile is variable and typically not diagnostic. Despite some worrisome histologic features, they appear uniformly benign in their behavior.

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A benign gonadal stromal tumor of the testis of spindle fibroblastic type

Cited by 18 publications

References 6 publications

Testicular (gonadal stromal) fibroma: Case report

Testicular (gonadal stromal) fibroma: Case report

Testicular (gonadal stromal) fibroma: Case report and review of the literature

Testicular Fibrothecoma

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