Testicular (gonadal stromal) fibroma: Case report and review of the literature

Deveci̇, Mustafa; Deveci, Güzin; Öngürü, Önder; Kilciler, Mete; Celasun, Bülent

doi:10.1046/j.1440-1827.2002.01345.x

Cited by 14 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average age of patients with TF is 31 (2). In our case, the patient denied any infection or trauma in the area of the testicle which is consistent with the data from Deveci et al (3). With our patient, there was no pain in the testicle, increase in tumor markers or pathological findings in the analysis of blood and urine, the same as with Pinieux et al, Renshaw et al, and Allen et al (7,5,8).…”

Section: Discussionsupporting

confidence: 92%

“…With our patient, there was no pain in the testicle, increase in tumor markers or pathological findings in the analysis of blood and urine, the same as with Pinieux et al, Renshaw et al, and Allen et al (7,5,8). Only a small number of cases of TF grew rapidly and were accompanied by pain (2,3). The tumor is most often localized in the central part of the testicular parenchyma having no contact with the tunic albuginea.…”

Section: Discussionsupporting

confidence: 83%

“…The tumor grows unilaterally, gradually, sometimes accompanied by pain (2). Tumor growth is neither accompanied by hormone disorders, nor have there been cases of metastasis or disease relapse (3).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Testicular (gonadal stromal) fibroma: Case report

et al. 2012

View full text Add to dashboard Cite

Testicular fibroma is a rare benign tumor of gradual growth, usually in the third and fourth decade, in the form of a hypoechogenous nodule with clear boundaries and is usually not accompanied by hormonal abnormalities. Metastasis and recurrence of disease were not noted. A 40-year-old male saught medical attention due to pain in the lower back that spread to the pubic bones and the groin. During physical examination, a painless nodule with clear boundaries was palpated in the right testicle, and the ultrasonographic examination revealed hypoechogenic zone with vague boundaries of about 10 mm in diameter. Standard biochemical analyses of blood and urine tests and tumor markers (CEA, CA 125, CA 19-9, AFP and βHCG) were within the physiological limit. Histopathologic analysis set a diagnosis of testicular fibroma. The absence of sex cords in the tumor tissue made it possible to diagnose the patient using standard staining methods, but in cases where these elements can be histologically verified, immunohistochemical analysis should be introduced into a routine diagnostic algorithm

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Testicular (gonadal stromal) fibroma: Case report

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In Sertoli and Leydig cell tumors, features such as >3 or >5 mitoses per 10 HPF, size >5 cm, and an infiltrative border have been associated with an increased 12 In the series by Jones and colleagues, 1 case had up to 4 mitoses per 10 HPF and was without evidence of progression at either 2, 3, or 8 years after surgery (follow-up not specified for individual cases). In the current study, of the 2 men with 9 to 10 mitoses per 10 HPF, 1 died of other causes 5 years and 8 months later, and the other had no evidence of disease at 4 years and 10 months after surgery.…”

Section: Discussionmentioning

confidence: 99%

Testicular Fibrothecoma

Zhang¹,

Kao

Ulbright

et al. 2013

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Benign intratesticular spindle cell lesions are rare. Herein, we report the morphology, immunohistochemical characteristics, and prognosis of 16 cases of testicular fibrothecoma. The mean age at diagnosis was 44 years (16 to 69 y). Of 15 patients with information, 14 presented with a palpable testicular mass and 1 with heaviness in the scrotum. Medical histories included bilateral orchidopexy as a child (n=1) and testicular atrophy receiving testosterone replacement (n=1). The average size was 1.8 cm (median 2 cm; range, 0.5 to 7.6 cm). All cases were intratesticular, although 13 were abutting the tunica albuginea with others centered on the rete testis (n=2), or were indeterminate on biopsy (n=1). Eleven cases were relatively well circumscribed, although not encapsulated, with 1 being infiltrative and 4 not evaluable. Four tumors showed entrapment of seminiferous tubules. Half of the fibrothecomas showed a mixed storiform pattern and short fascicles, with 6 storiform only and 2 short fascicles only. One half of the tumors were very hypercellular. Cases were equally split between having plumper ovoid as opposed to spindled pointed nuclei, with all cases lacking prominent nucleoli. Eleven cases had 0 to 2 mitoses per 10 HPF, 3 had 4 to 5 mitoses per 10 HPF, and 2 had 9 to 10 mitoses per 10 HPF. Collagen deposition either in bands or investing single cells ranged from none to extensive, with 10/16 cases having at least a moderate amount. Immunohistochemical positivity was as follows: inhibin (11/13, patchy to diffuse); calretinin (5/9); Melan-A (4/4); pan keratin (5/8); BCL2 (3/4); CD34 (3/8); S100 (4/8); muscle-specific actin (4/4); and desmin (5/8). Patients were followed up for a mean of 71.8 months (range, 3 to 144 mo). All were well with no evidence of disease. Of the 2 men with 9 to 10 mitoses per 10 HPF, 1 died of other causes 5 years and 8 months later, and the other had no evidence of disease at 4 years and 10 months after surgery. In summary, testicular fibrothecomas are rare with somewhat variable histology and can have worrisome histologic features such as minimal invasion into surrounding testis, high cellularity, and increased mitotic rate. Their immunoprofile is variable and typically not diagnostic. Despite some worrisome histologic features, they appear uniformly benign in their behavior.

show abstract

“…In the testis there is the rare possibility of tumors with exclusive fibrous and spindle cell components which do not involve the paratesticular tissue. Few cases have been reported of benign testicular gonadal stromal tumor with only spindle cells [8]. Few cases have been observed with atypic spindle tumor cells with nuclear pleiomorphism, numerous mitoses and blunt edged nuclei suggesting malignant tumors of smooth muscle origin.…”

Section: Discussionmentioning

confidence: 99%

Primitive Testicular Leiomyosarcoma

Raspollini

Stomaci

Ringressi

et al. 2009

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Primary testicular leiomyosarcoma is an uncommon tumor with only few cases described in literature. In young people this rare tumor seems to be related to radiotherapy and anabolic steroids abuse. In older people there are apparently no risk factors. We describe one further case in a 77-years old man with full histological and ultrastructural evaluation. A short term follow-up of one year signals no recurrence of the disease.

show abstract

Testicular (gonadal stromal) fibroma: Case report and review of the literature

Cited by 14 publications

References 13 publications

Testicular (gonadal stromal) fibroma: Case report

Testicular (gonadal stromal) fibroma: Case report

Testicular Fibrothecoma

Primitive Testicular Leiomyosarcoma

Contact Info

Product

Resources

About