A behavioral study of the nature of verb production deficits in Alzheimer’s disease

Beber, Bárbara Costa; Cruz, Aline Nunes da; Chaves, Márcia Lorena Fagundes

doi:10.1016/j.bandl.2015.07.010

Cited by 23 publications

(28 citation statements)

References 51 publications

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“…Therefore, in the current pilot study, we tested individuals with dementia and cognitively healthy older adults (without a diagnosis of dementia) not only to compare their brain activation patterns, but also to determine brain regions closely associated with verb fluency performance. It was hypothesized that individuals with dementia will show significant upregulation of frontal lobe areas given the increased burden of search strategies dealing with degraded semantic information and access (Melrose et al, 2009;Reilly et al, 2011;Beber et al, 2015;Methqal et al, 2019); this hypothesis is also consistent with prior work documenting that impairments in verb fluency are associated with frontal lobe lesions (Piatt et al, 1999;Davis et al, 2010;Beber and Chaves, 2014). Additionally, it was hypothesized that there will be subcortical and deep brain regions exhibiting significant correlations with verb fluency performance.…”

Section: Introductionsupporting

confidence: 67%

“…For instance, verb fluency (originally referred to as action fluency; see Piatt et al, 1999 for validity;Woods et al, 2005 for normative data) appears sensitive to cognitive deficits stemming from frontal-striatal impairments (Kochhann et al, 2018). Indeed, individuals with mild cognitive impairment (MCI) or subjective cognitive decline (SCD) have been found to show impaired verb fluency performance (Östberg et al, 2005Forlenza et al, 2012;Alegret et al, 2018;Macoir et al, 2019) as have individuals with Alzheimer's disease (AD; Östberg et al, 2007;McDowd et al, 2011;Beber et al, 2015;Dubois et al, 2016;Alegret et al, 2018) and individuals with Parkinson's disease (PD) dementia (Piatt et al, 1999). Verb fluency tasks have also been used to predict dementia severity (e.g., Lai and Lin, 2013) and aid in the differential diagnosis of frontotemporal lobar degeneration (FTLD) vs.…”

Section: Introductionmentioning

confidence: 99%

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Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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Currently there are ∼6 million Americans who are affected by dementia. Verbal fluency tasks have been commonly and frequently utilized to document the disease progression in many forms of dementia. Verb fluency has been found to display substantial potential to detect and monitor the cognitive declines of individuals with dementia who have fronto-striatal involvement. The neural substrates underlying verb fluency task performance, however, have remained unclear so far, especially in individuals with dementia. Therefore, in the current study, brain activation patterns of seven individuals with dementia and nine healthy older adults were investigated using functional MRI. The participants performed in the scanner an overt, subject-paced verb fluency task, representative of fluency tasks used in clinical settings. The brain activation patterns during the verb fluency task were compared between the two groups, and a correlational analysis was conducted to determine the neural correlates of verb fluency performance. The results suggest that compared to healthy older adults, individuals with dementia demonstrated poorer verb fluency performance and showed higher activation in specific neural regions, such as the bilateral frontal lobe. In addition, the correlational analysis revealed that poorer verb fluency performance lead to increased activation in certain cortical and subcortical areas, including left hippocampus and right supramarginal gyrus. The current findings are consistent with previous neurophysiological findings related to semantic (noun) fluency performance in older adults and individuals with dementia and add to the empirical evidence that supports the role of the frontal lobe and hippocampus in verb retrieval and search. Declines in verb fluency performance cannot only be used as a cognitive marker, but also represent neuropathological changes due to the neurodegenerative disease.

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Section: Introductionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Paek

Murray

Newman

2020

Front. Aging Neurosci.

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“…The verb fluency refers to the generation of as many verbs (or actions or things that people do) as possible in a given time, allowing the production of verbs denoting concrete actions (i.e., to run) or internal states (i.e., to think) [21]. This type of verbal fluency task assesses language and executive functions and it is sensitive to dysfunctions in fronto-subcortical networks linking primary and secondary motor cortex, frontal lobes and basal ganglia [19][20][21]23,[40][41][42][43][44]. Since the generation of verbs has also been related to neocortical-hippocampal interaction, mainly the perirhinal cortex, which receives reciprocal inputs from associative regions (prefrontal, insular and anterior cingulate cortices) [45], verb fluency has been proposed as a sensitive test detecting early dysfunctions associated with AD.…”

Section: Introductionmentioning

confidence: 99%

The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer’s Disease

Alegret

Peretó

Pérez

et al. 2018

JAD

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“…It is suggested that picture naming is a task predominantly dependent on temporal or posterior brain areas, whereas verbal fl uency is more dependent on frontal or frontalsubcortical brain areas. Even though patients with AD have no frontal brain atrophy, they do experience diffi culty in naming and fl uency tasks involving verbs (Beber, Cruz & Chaves, 2015).…”

Section: Discussionmentioning

confidence: 99%

Language Changes in Late-Onset Alzheimer’s Disease

Can

Kuruoğlu

2019

Psycholing.

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Alzheimer’ s disease (AD) is the most common cause of cognitive decline and dementia in the elderly. Language disturbances appear early in AD and constitute an important element of the diagnosis, although they are usually overshadowed by impairment of memory and executive functions. It is known that language is impaired disproportionally in AD: the semantic and pragmatic language systems are more impaired than syntax. However, syntactic features can also be impaired in the moderate and severe stages of AD. The features of language can be different depending on the onset of AD. AD is classified into two subtypes: early-onset (before 65 years of age) and late-onset (over 65 years of age). Late-onset is the most common form of AD and the aim of this study is to reveal the language changes of 39 patients with late-onset AD and compare it with an age/education-matched control group that has no neurological and psychological problems. The data was transcribed using transcript symbols following Du Bois. The results revealed that although the number of the sentences were more, the speech amount of late-onset AD patients was smaller than the control group. Late-onset AD patients mostly produced sentences in “Picnic” picture description test and fewer sentences in random speech test. Moreover, the sentence length of LAD patients was bigger in “Cookie theft” picture description test and smaller in “Picnic” picture description test. However, their general performance about the speech amount was poor. The other findings were about the coordinated and compound sentences. It was revealed that late-onset AD patients used similar number of coordinated and compound sentences compared to their aged matched peers. In conclusion, it is clear that the syntactic features of LAD patients is not completely different from the people with normail aging.

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A behavioral study of the nature of verb production deficits in Alzheimer’s disease

Cited by 23 publications

References 51 publications

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

Neural Correlates of Verb Fluency Performance in Cognitively Healthy Older Adults and Individuals With Dementia: A Pilot fMRI Study

The Role of Verb Fluency in the Detection of Early Cognitive Impairment in Alzheimer’s Disease

Language Changes in Late-Onset Alzheimer’s Disease

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