“…On the distal end of OCT imaging probe, MEMS scanners and actuators play a crucial role in the miniaturization of the endomicroscope. After the first introduction of the electro-thermal scanner based OCT system by Xie et al [ 43 ], researchers have made significant progress on the MEMS based OCT imaging system [ 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ]. The in vivo endomicroscopic imaging with angled vertical comb-drive (AVC) actuated MEMS scanner ( Figure 5 a) based OCT endomicroscope was demonstrated for the first time by Piyawattanametha and colleagues at MIT [ 46 , 47 ].…”