This paper uses detrital zircon (DZ) provenance and geochronological data to reconstruct paleodrainage areas and lengths for sediment-routing systems that fed the Cenomanian Tuscaloosa-Woodbine, Paleocene Wilcox, and Oligo cene Vicksburg-Frio clastic wedges of the northern Gulf of Mexico (GoM) margin. During the Cenomanian, an ancestral Tennessee-Alabama River system with a distinctive Appalachian DZ signature was the largest system contributing water and sediment to the GoM, with a series of smaller systems draining the Ouachita Mountains and discharging sediment to the western GoM. By early Paleocene Wilcox deposition, drainage of the southern half of North America had reorganized such that GoM contributing areas stretched from the Western Cordillera to the Appalachians, and sediment was delivered to a primary depocenter in the northwestern GoM, the Rockdale depocenter fed by a paleo-Brazos-Colorado River system, as well as to the paleo-Mississippi River in southern Louisiana. By the Oligocene, the western drainage divide for the GoM had migrated east to the Laramide Rockies, with much of the Rockies now draining through the paleo-Red River and paleo-Arkansas River systems to join the paleo-Mississippi River in the southern Mississippi embayment. The paleo-Tennessee River had diverted to the north toward its present-day junction with the Ohio River by this time, thus becoming a tributary to the paleo-Mississippi within the northern Mississippi embayment. Hence, the paleo-Mississippi was the largest Oligocene system of the northern GoM margin. Drainage basin organization has had a profound impact on sediment delivery to the northern GoM margin. We use paleodrainage reconstructions to predict scales of associated basin-floor fans and test our predictions against measurements made from an extensive GoM database. We predict large fan systems for the Cenomanian paleo-Tennessee-Alabama, and especially for the two major depocenters of the early Paleocene paleo-Brazos-Colorado and late Paleocene-earliest Eocene paleo-Mississippi systems, and for the Oligocene paleo-Mississippi. With the notable exception of the Oligocene, measured fans reside within the range of our predictions, indicating that this approach can be exported to other basins that are less data rich.