A balanced brain asymmetry modulates T cell-mediated events

Renoux, G; Biziere, Kathleen; Renoux, M; Guillaumin, Jean‐Maurice; Degenne, Danielle

doi:10.1016/0165-5728(83)90043-7

Cited by 111 publications

(28 citation statements)

References 23 publications

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“…In one of the first studies Bardos et al [12] found out that NK-cell (natural killers) activity was significantly impaired following left cortical lesions, whereas right cortical lesions exerted no observable influence on NK-cell activity, as compared with normal control animals. Renoux et al [13] observed weight reduction in lymphoid organs (spleen and thymus), and a decreased number of splenic T-cells (Thy-1+) also in left cortical lesioned mice. The study of lymphocyte proliferation in response to mitogen stimulation provided evidence that left cortical ablation significantly suppresses the response of splenic lymphocytes to T-cell specific mitogens such as phytohemagglutinin and concanavalin [5].…”

Section: Hemispheric Lateralization In Neuroimmunomodulationmentioning

confidence: 99%

Brain asymmetry, immunity, handedness

et al. 2011

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AbstractThe principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.

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Section: Hemispheric Lateralization In Neuroimmunomodulationmentioning

confidence: 99%

Brain asymmetry, immunity, handedness

et al. 2011

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“…Left and right brain hemispheres exert opposed actions on peripheral immune response [34,35]. We showed here that IL-6 is asymmetrically distributed in cortex and hippocampus, two structures involved in the central regulation of peripheral immune responses [3,36].…”

Section: Discussionmentioning

confidence: 97%

Asymmetrical Distribution of Brain Interleukin-6 Depends on Lateralization in Mice

Shen

Hébert

Moze

et al. 2005

Neuroimmunomodulation

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The central nervous system can regulate the peripheral immune system. Moreover, differences between left and right hemispheres (neurochemical brain asymmetries) and behavioral lateralization (functional brain asymmetries) affect immune responses. The molecular basis of brain-immune interactions remains insufficiently understood. Cytokines regulate immune responses, possibly through activation of the hypothalamic-pituitary-adrenal (HPA) axis. HPA axis activities are related to behavioral lateralization and brain asymmetry. Given IL-6 plays a role in asymmetrical brain immunomodulation, one might expect the IL-6 distribution in brain to be asymmetrical and to depend on behavioral lateralization. In order to start to test this hypothesis, male C57BL/6J mice were selected for paw preference and assessed for IL-6 levels in right and left cortex and hippocampus by enzyme linked immunosorbent assay. The results showed asymmetrical distribution of brain IL-6 in left-pawed animals and ambidextrous animals, but not in right-pawed animals, both in cortex and hippocampus. Furthermore, we found a correlation between IL-6 hemispheric distribution and the degree of behavioral lateralization both in cortex and hippocampus. Altogether, these results suggest that brain IL-6 could be a mediator of asymmetrical immunomodulation by the central nervous system.

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“…Morphological, neurochemical and behavioral asymmetries have also been described in a number of animal species. Many researchers traditionally studied brain asymmetries underlying cerebral cortical lesions [2]. However, in severe injury models using lesions, feedback mechanisms and the other unstable factors are involved.…”

Section: Introductionmentioning

confidence: 99%

The level of nitric oxide in the cortex correlates well with brain lateralization

Yan³

et al. 2004

NeuroReport

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The correlation between nitric oxide (NO) levels in the cortices and brain lateralization was investigated via the paw preference test in which three groups of mice (left-pawed, ambidextrous and right pawed) were selected. Results showed that the right cortices had higher NO levels than the left cortices for both normal and lipopolysaccharide-treated mice. There were significant differences in NO levels in the right/left cortices depending on the behavioral lateralization as expressed by paw preference. Finally, individual levels of NO in the right/left cortices correlated well with individual paw preference scores. The relationship was parabolic. The results suggest a strong relationship between NO asymmetries as well as the direction and the intensity of behavioral lateralization.

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A balanced brain asymmetry modulates T cell-mediated events

Cited by 111 publications

References 23 publications

Brain asymmetry, immunity, handedness

Brain asymmetry, immunity, handedness

Asymmetrical Distribution of Brain Interleukin-6 Depends on Lateralization in Mice

The level of nitric oxide in the cortex correlates well with brain lateralization

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