A Balanced Approach for Cannabidiol Use in Chronic Pain

Argueta, Donovan A; Ventura, Christopher; Kiven, Stacy B; Sagi, Varun; Gupta, Kalpna

doi:10.3389/fphar.2020.00561

Cited by 39 publications

(40 citation statements)

References 62 publications

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“…This finding is in alignment with similar reports describing CBD effects ranging from placebo-equivalent to highly effective. 13 The effects of CBM and CBD on painful conditions seem to be context specific, with no effect on pain shown in patients with Crohn’s disease, 26 and pain-relieving effects reported for pain associated with Multiple Sclerosis, spinal cord injury, brachial plexus injury, limp amputation, 27 peripheral neuropathy 28 and fibromyalgia. 29 This cohort also reported that products both with and without THC have helped them to reduce overall pain medication and more specifically opioid medication.…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

Schilling¹,

Hughes²,

Wallace³

et al. 2021

JPR

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Section: Discussionmentioning

confidence: 99%

Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

Schilling¹,

Hughes²,

Wallace³

et al. 2021

JPR

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“…The underlying mechanisms for the analgesic effect of CBD are subject to debate. However, previous studies have proposed CBD's interaction with the glycine and serotonergic systems as possible vehicles ( 63 ). In animal models of arthritis, locally applied CBD has been found to lessen joint pain and inflammation ( 64 – 66 ).…”

Section: Discussionmentioning

confidence: 99%

A Multiple Correspondence Analysis of Patterns of CBD Use in Hemp and Marijuana Users

2021

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Background: With the passing of the 2018 Agriculture Improvement Act that legalized hemp-derived products, i.e., cannabidiol (CBD), the use of CBD has increased exponentially. To date, the few studies that have characterized individuals who use CBD suggest that co-use of CBD and tetrahydrocannabinol (THC)-dominant cannabis, i.e., marijuana, is highly prevalent. It is, therefore, important to investigate the relationship between CBD use and marijuana use to understand the antecedents and consequences of co-use of these two cannabis products.Methods: We conducted an online survey using structured questionnaires to determine differences in CBD users with (CBD+MJ) and without co-morbid marijuana use. Group comparisons were carried out using chi-square tests and ANOVA. Multiple correspondence analysis (MCA) with bootstrap ratio testing was performed to examine the relationship between the categorical data.Results: We received 182 survey responses from current CBD users. CBD+MJ had more types of CBD administration (F = 17.07, p < 0.001) and longer lifetime duration of CBD use (χ2 = 12.85, p < 0.05). Results from the MCA yielded two statistically significant dimensions that accounted for 77% of the total variance. Dimension 1 (representing 57% of the variance) associated CBD+MJ with indication of CBD use for medical ailments, use of CBD for more than once a day for longer than 2 years, applying CBD topically or consuming it via vaping or edibles, being female, and, having lower educational attainment. Dimension 2 (representing 20% of the variance) separated the groups primarily on smoking-related behaviors where CBD+MJ was associated with smoking CBD and nicotine.Conclusions: Identifying the factors that influence use of CBD and marijuana can inform future studies on the risks and benefits associated with each substance as well as the impacts of policies related to cannabis-based products.

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“…Anticancer and antitumor (Lukhele and Motadi 2016 ; Velasco et al 2012 , 2016 ), analgesic (Argueta et al 2020 ; Comelli et al 2008 ), anti-arthritis (Lowin et al 2020 ), anti-spasticity (Hagenbach et al 2007 ; Leussink et al 2012 ), antibacterial, antimicrobial (Appendino et al 2008 , Monika and Kaur, 2014 , Pellegrini et al 2020 )…”

Section: Resultsmentioning

confidence: 99%

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

Shakil

Gowan

Hughes³

et al. 2021

J Cannabis Res

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Background There is a worldwide interest in the use of Cannabis sativa for biomedicine purposes. Cannabis has ethnomedicinal usage as a natural medicine in Bangladesh and cultivated during the British Empire period for revenues. Objective Folk medicine practitioners (FMPs) from different districts of Bangladesh have been using Cannabis sativa, but until now there have not been any compiled studies particularly regarding this practice. Hence, this review is an effort to retrieve the traditional usage of Cannabis sativa as a phytomedicine from published ethnomedicinal studies. Methods and materials Information was searched by using the search terms “ethnomedicinal Cannabis sativa and Bangladesh”; “Bangladesh cannabaceae and ethnomedicinal survey”; “ganja, bhang and folk medicine Bangladesh”; “tetrahydrocannabinol (THC), cannabinoid and therapeutic, clinical trial”; and “cannabis and pharmacological/biological” and retrieved from ethnobotanical articles available on PubMed, Scopus, Science Direct, and Google Scholar databases. A search of the relevant scientific literature also was conducted to assess the efficacy of the ethnomedicinal usage of Cannabis sativa. Results While reviewing over 200 ethnomedicinal plants’ survey articles, we found that FMPs of Bangladesh from 12 different districts used Cannabis sativa to treat cited ailments like sleep-associated problems (n=5), neuropsychiatric and CNS problems (n=5), and infections and respiratory problems (n=5) followed by rheumatism, gastrointestinal, gynecological (n=4 each), cancer, sexual, and other ailments including hypertension, headache, itch, increases bile secretion, abortifacient, dandruff, fever, and urinary problems (n=1 each). There are a total of 15 formulations identified from the 11 out of 18 ethnomedicinal plant survey reports. The leaf was the main plant part used (53.8%), followed by root (23%), seed (7.7%) and flower, inflorescence, resin, and all parts 3.8% respectively. Conclusions Sales and cultivation of Cannabis are illegal at present in Bangladesh, but the use of Cannabis sativa as a natural phytomedicine has been practiced traditionally by folk medicine practitioners of Bangladesh for many years and validated through relevant pharmacological justification. Although Cannabis sativa possesses ethnomedicinal properties in the folk medicine of Bangladesh, it is, furthermore, needed to conduct biological research to consolidate pharmacological justification about the prospects and challenges of Cannabis and cannabinoids’ use in Bangladesh as safer biomedicine in the future.

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A Balanced Approach for Cannabidiol Use in Chronic Pain

Cited by 39 publications

References 62 publications

Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

A Multiple Correspondence Analysis of Patterns of CBD Use in Hemp and Marijuana Users

A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh

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