Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

Schilling, Jan M.; Hughes, Chloe G; Wallace, Mark; Sexton, Michelle; Bačkonja, Miroslav; Moeller-Bertram, Tobias

doi:10.2147/jpr.s278718

Cited by 25 publications

(16 citation statements)

References 44 publications

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“…Our review of survey data is consistent with other survey-based studies of general pain conditions, where most respondents indicated improved pain from cannabis use. 36 However, due to their methodology, these studies had several limitations, including the possibility of selection and response biases. Additionally, it was not possible to compare the effect of cannabis relative to placebo or another analgesic.…”

Section: Discussionmentioning

confidence: 99%

Medical Cannabis for Gynecologic Pain Conditions

Liang

Gingher

Coleman

2022

Obstetrics &Amp; Gynecology

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The endocannabinoid system is involved in pain perception and inflammation. Cannabis contains delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which are cannabinoids that bind to endocannabinoid system receptors. A fatty acid amide called palmitoylethanolamide (PEA) enhances endogenous cannabinoids. Given that use of medical cannabis is increasing, we sought to characterize patterns of cannabis use for gynecologic pain and its effectiveness as an analgesic.DATA SOURCES: We searched PubMed, EMBASE, Scopus, Cochrane, and ClinicalTrials.gov using terms for "woman," "cannabis," and "pain" or "pelvic pain" or "endometriosis" or "bladder pain" or "cancer." The search was restricted to English-language articles published between January 1990 and April 2021 and excluded animal studies. METHODS OF STUDY SELECTION:The initial search yielded 5,189 articles with 3,822 unique citations. Studies were included if they evaluated nonpregnant adult women who used cannabinoids for gynecologic pain conditions (eg, chronic pelvic pain, vulvodynia, endometriosis, interstitial cystitis, malignancy). Study types included were randomized controlled trials (RCTs), cohort studies, and cross-sectional studies. Covidence systematic review software was used.

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Section: Discussionmentioning

confidence: 99%

Medical Cannabis for Gynecologic Pain Conditions

Liang

Gingher

Coleman

2022

Obstetrics &Amp; Gynecology

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“…A survey investigating patients’ perspectives and attitudes about CBD for the treatment of pain symptoms showed that 62% of the participants used a CBD product. Furthermore, the majority of patients (59%) who ever used CBD products perceived reductions in pain and in 67.6% of these patients, the use of CBD allowed them to reduce their pain medications ( Schilling et al, 2021 ). Another explorative study evaluated the effect of CBD treatment on self-reported quality of life and showed that patients with (non-)cancer chronic pain symptoms reported reductions in pain scores upon CBD treatment, while patients with neurological symptoms did not perceive any improvements ( Gulbransen et al, 2020 ).…”

Section: Implications For the Potential Of Cbd As A Therapeutic Agentmentioning

confidence: 99%

Cannabidiol and brain function: current knowledge and future perspectives

Schouten,

Dalle,

Mantini

et al. 2024

Front. Pharmacol.

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Cannabidiol (CBD) is a naturally occurring non-psychoactive cannabinoid found in Cannabis sativa, commonly known as cannabis or hemp. Although currently available CBD products do not meet the safety standards of most food safety authorities to be approved as a dietary supplement or food additive, CBD has been gaining widespread attention in recent years due to its various potential health benefits. While primarily known for its therapeutic effects in managing epileptic seizures, psychosis, anxiety, (neuropathic) pain, and inflammation, CBD’s influence on brain function has also piqued the interest of researchers and individuals seeking to enhance cognitive performance. The primary objective of this review is to gather, synthesize, and consolidate scientifically proven evidence on the impact of CBD on brain function and its therapeutic significance in treating neurological and mental disorders. First, basic background information on CBD, including its biomolecular properties and mechanisms of action is presented. Next, evidence for CBD effects in the human brain is provided followed by a discussion on the potential implications of CBD as a neurotherapeutic agent. The potential effectiveness of CBD in reducing chronic pain is considered but also in reducing the symptoms of various brain disorders such as epilepsy, Alzheimer’s, Huntington’s and Parkinson’s disease. Additionally, the implications of using CBD to manage psychiatric conditions such as psychosis, anxiety and fear, depression, and substance use disorders are explored. An overview of the beneficial effects of CBD on aspects of human behavior, such as sleep, motor control, cognition and memory, is then provided. As CBD products remain largely unregulated, it is crucial to address the ethical concerns associated with their use, including product quality, consistency, and safety. Therefore, this review discusses the need for responsible research and regulation of CBD to ensure its safety and efficacy as a therapeutic agent for brain disorders or to stimulate behavioral and cognitive abilities of healthy individuals.

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“…Participants were also questioned regarding the type of products they used, choosing more than one form of use. Inhaled/smoked products were the most common type of products used (62.9%), followed by edibles (54.3%), oral tinctures (52.3%), ointment/oil, and cream (49.7%) [31].…”

Section: Different Forms Of Cannabis and Patient Preferencesmentioning

confidence: 99%

Medical Cannabis for Chronic Nonmalignant Pain Management

Hameed

Prasad

Jain

et al. 2023

Curr Pain Headache Rep

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Purpose of Review Cannabis has been used since ancient times for medical and recreational research. This review article will document the validity of how medical cannabis can be utilized for chronic nonmalignant pain management. Recent Findings Current cannabis research has shown that medical cannabis is indicated for symptom management for many conditions not limited to cancer, chronic pain, headaches, migraines, and psychological disorders (anxiety and post-traumatic stress disorder). Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) are active ingredients in cannabis that modulate a patient's symptoms. These compounds work to decrease nociception and symptom frequency via the endocannabinoid system. Research regarding pain management is limited within the USA as the Drug Enforcement Agency (DEA) classifies it as a schedule one drug. Few studies have found a limited relationship between chronic pain and medical cannabis use. Summary A total of 77 articles were selected after a thorough screening process using PubMed and Google Scholar. This paper demonstrates that medical cannabis use provides adequate pain management. Patients suffering from chronic nonmalignant pain may benefit from medical cannabis due to its convenience and efficacy.

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Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients’ Perspectives and Attitudes

Cited by 25 publications

References 44 publications

Medical Cannabis for Gynecologic Pain Conditions

Medical Cannabis for Gynecologic Pain Conditions

Cannabidiol and brain function: current knowledge and future perspectives

Medical Cannabis for Chronic Nonmalignant Pain Management

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