A bacterial cell–cell communication signal with cross‐kingdom structural analogues

Wang, Lianhui; He, Yanan; Gao, Yunfeng; Wu, Ji En; Dong, Ying; He, Chaozu; Wang, Su Xing; Weng, Lixing; Xu, Jiahao; Tay, L.; Fang, Rong; Zhang, Lian-Hui

doi:10.1046/j.1365-2958.2003.03883.x

Cited by 401 publications

(430 citation statements)

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“…DSF from the crucifer pathogen Xanthomonas campestris pv. campestris (Xcc) has been shown to be the unsaturated fatty acid cis-11-methyl-dodecenoic acid (5). Both the synthesis and perception of the DSF signal require products of the regulation of pathogenicity factors (rpf) gene cluster (1,4,6).…”

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confidence: 99%

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Cell–cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

Ryan

McCarthy²,

Andrade³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

137

183

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confidence: 99%

“…The virulence of these bacteria depends on cell-to-cell signaling mediated by the diffusible signal molecule, diffusible signaling factor (DSF) (1)(2)(3)(4)(5). DSF from the crucifer pathogen Xanthomonas campestris pv.…”

mentioning

confidence: 99%

Cell–cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

Ryan

McCarthy²,

Andrade³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

137

183

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“…campestris DSF molecule was described as cis-11-methyl-2-dodecanoic acid (Barber et al 1997;Wang et al 2004); while X. fastidiosa can respond to Xanthomonas ssp. DSF, the weaker response (Newman et al 2004) suggested that X. fastidiosa synthesizes and responds to a distinct DSF molecule.…”

Section: Host Switching and Cell-cellmentioning

confidence: 99%

Genomic Insights into Xylella fastidiosa Interactions with Plant and Insect Hosts

Retchless

Labroussaa

Shapiro

et al. 2014

Genomics of Plant-Associated Bacteria

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“…These ecological interactions in general and prokaryote-eukaryote interactions in particular, are likely important for the evolution and maintenance of microbial virulence toward humans (4,5). Moreover, humans are often co-infected or colonized with multiple pathogens (1,6), whose interactions may determine the virulence potential of either organism.…”

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confidence: 99%

Prokaryote–eukaryote interactions identified by using Caenorhabditis elegans

Peleg

Tampakakis

Fuchs

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

169

171

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Prokaryote-eukaryote interactions are ubiquitous and have important medical and environmental significance. Despite this, a paucity of data exists on the mechanisms and pathogenic consequences of bacterial-fungal encounters within a living host. We used the nematode Caenorhabditis elegans as a substitute host to study the interactions between two ecologically related and clinically troublesome pathogens, the prokaryote, Acinetobacter baumannii, and the eukaryote, Candida albicans. After co-infecting C. elegans with these organisms, we observed that A. baumannii inhibits filamentation, a key virulence determinant of C. albicans. This antagonistic, crosskingdom interaction led to attenuated virulence of C. albicans, as determined by improved nematode survival when infected with both pathogens. In vitro coinfection assays in planktonic and biofilm environments supported the inhibitory effects of A. baumannii toward C. albicans, further showing a predilection of A. baumannii for C. albicans filaments. Interestingly, we demonstrate a likely evolutionary defense by C. albicans against A. baumannii, whereby C. albicans inhibits A. baumannii growth once a quorum develops. This counteroffensive is at least partly mediated by the C. albicans quorum-sensing molecule farnesol. We used the C. elegans-A. baumannii-C. albicans coinfection model to screen an A. baumannii mutant library, leading to the identification of several mutants attenuated in their inhibitory activity toward C. albicans. These findings present an extension to the current paradigm of studying monomicrobial pathogenesis in C. elegans and by use of genetic manipulation, provides a whole-animal model system to investigate the complex dynamics of a polymicrobial infection.A. baumannii ͉ C. albicans ͉ Acinetobacter ͉ pathogenesis ͉ biofilm

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A bacterial cell–cell communication signal with cross‐kingdom structural analogues

Cited by 401 publications

References 50 publications

Cell–cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

Cell–cell signal-dependent dynamic interactions between HD-GYP and GGDEF domain proteins mediate virulence in Xanthomonas campestris

Genomic Insights into Xylella fastidiosa Interactions with Plant and Insect Hosts

Prokaryote–eukaryote interactions identified by using Caenorhabditis elegans

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