Prokaryote–eukaryote interactions identified by using
            <i>Caenorhabditis elegans</i>

Peleg, Anton Y.; Tampakakis, Emmanouil; Fuchs, Beth Burgwyn; Eliopoulos, George M.; Moellering, Robert C.; Mylonakis, Eleftherios

doi:10.1073/pnas.0805048105

Cited by 169 publications

(174 citation statements)

References 35 publications

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“…Filament formation has been shown to be a key C. albicans virulence mechanism in mammals. When the worms were infected with A. baumannii and C. albicans, no fungal filaments were produced, and the worms survived for a longer period of time compared to infection with C. albicans alone (41). Thus, A. baumannii was affecting the viability and virulence of C. albicans.…”

Section: Use Of In Vivo Non-mammalian Model Systems To Study a Baumamentioning

confidence: 94%

“…A further study extended the paradigm of using C. elegans to study microbial pathogenesis by using the model system to study polymicrobial infections (41). This study investigated the interactions between C. albicans, the most common human fungal pathogen, and A. baumannii within a living host.…”

Section: Use Of In Vivo Non-mammalian Model Systems To Study a Baumamentioning

confidence: 99%

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Insights into Acinetobacter baumannii pathogenicity

2011

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SummaryAcinetobacter spp. have justifiably received significant attention from the public, scientific, and medical communities. Over recent years, Acinetobacter, particularly Acinetobacter baumannii, has become a ''red-alert'' human pathogen, primarily because of its exceptional ability to develop resistance to all currently available antibiotics. This characteristic is compounded by its unique abilities to survive in a diverse range of environments, including those within healthcare institutions, leading to problematic outbreaks. Historically, the virulence of the organism has been questioned, but recent clinical reports suggest that Acinetobacter can cause serious, life-threatening infections. Furthermore, its metabolic adaptability gives it a selective advantage in harsh hospital environments. This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism.

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Section: Use Of In Vivo Non-mammalian Model Systems To Study a Baumamentioning

confidence: 94%

Section: Use Of In Vivo Non-mammalian Model Systems To Study a Baumamentioning

confidence: 99%

Insights into Acinetobacter baumannii pathogenicity

2011

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“…Bacteria and fungi indisputably interact physically and chemically with one another within an ecosystem (Peleg et al 2010). These interactions influence overall survival, colonization and virulence.…”

Section: Cross-kingdom Interactionsmentioning

confidence: 99%

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

2015

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Abstract:We have entered the Age of the Microbiome, with new studies appearing constantly and whole journals devoted to the human microbiome. While bacteria outnumber other gut microbes by orders of magnitude, eukaryotes are consistently found in the human gut and are represented primarily by the fungi. Compiling 36 studies 1917-2015 we found at least 267 distinct fungal taxa have been reported from the human gut, and seemingly every new study includes one or more fungi not previously described from this niche. This diversity, while impressive, is illusory. If we examine gut fungi, we will quickly observe a division between a small number of commonly detected species (Candida yeasts, Saccharomyces and yeasts in the Dipodascaceae, and Malassezia species) and a long tail of taxa that have been reported only once. Furthermore, an investigation into the ecology of these rare species reveals that many of them are incapable of colonization or long-term persistence in the gut. This paper examines what we know and have yet to learn about the fungal component of the gut microbiome, or "mycobiome", and an overview of methods. We address the potential of the field while introducing some caveats and argue for the necessity of including mycologists in mycobiome studies.

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“…Another important issue in this context is the existence of mixedspecies colonization. Several reports have shown that colonization by more than one species has an impact on the microbial community and the quorum-sensing system (Hogan et al, 2002(Hogan et al, , 2004Peleg et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

Weber

Schulz

Ruhnke

2010

Yeast

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Diseases caused by Candida species are an increasing problem. Candida species are associated with high overall mortality, due to a variety of virulence factors such as the yeast-to-hyphal switch and proteolytic enzymes. The phenomenon of microbial communication known as quorum sensing also seems to play an important role. The main characteristics of the quorum-sensing molecule E ,E -farnesol are well known for C. albicans. The present study focused on two questions. One of them concerned the secretion of E ,E -farnesol by C. albicans and involved a close examination of the effect of the medium (serum) and the origin of the isolates used. The second one dealt with the activity of E ,E -farnesol in non-C. albicans species, such as C. tropicalis and C. parapsilosis, e.g. its impact on biofilm formation and growth. Under serum conditions, C. albicans produced up to 58% more E ,E -farnesol at 37• C than at 30• C. The growth of all isolates was reduced and delayed by the administration of E ,Efarnesol. Of all Candida species, C. tropicalis isolates were most strongly affected by the addition of E ,E -farnesol. Biofilm formation on polystyrene was affected by E ,Efarnesol treatment in all non-C. albicans species and C. albicans. E ,E -farnesol exerts its main effect by altering the metabolic activity and growth inhibition of treated Candida species. The results obtained indicate that the presence of E ,E -farnesol in the environment not only regulates the morphology of the Candida species but also affects its fitness. In this regard, the secretion of E ,E -farnesol might provide an advantage for members of the microbial community.

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Prokaryote–eukaryote interactions identified by using Caenorhabditis elegans

Cited by 169 publications

References 35 publications

Insights into Acinetobacter baumannii pathogenicity

Insights into Acinetobacter baumannii pathogenicity

The human gut mycobiome: pitfalls and potentials--a mycologists perspective

The quorum‐sensing molecule E,E‐farnesol—its variable secretion and its impact on the growth and metabolism of Candida species

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