A bacteria-triggered wearable colorimetric band-aid for real-time monitoring and treating of wound healing

Rapid Detection of Staphylococcus aureus Using Paper-Derived Electrochemical Biosensors

“…11 When deployed as point-of-care (POC) sensors, these devices can provide appropriate sensitivity to detect not only metabolites but also pathogens such as SARS-CoV-2 virus, 12 ebola virus, 13 Escherichia coli (E. coli), 14 or Staphylococcus aureus (S. aureus). 15,16 Considering that paper represents one of the most appealing materials to be attached to the skin (being inert, low-cost, non-toxic, and flexible), several groups have recently explored the idea of developing paper-based wearable devices, specifically targeting metabolites in sweat. 17,18 In general, these sensors can not only play an essential role as non-invasive tools to monitor multiple analytes in real time 19−21 but also provide information complementary to that potentially obtained by more complex (and invasive) systems.…”

“…coli), or Staphylococcus aureus (S. aureus). , Considering that paper represents one of the most appealing materials to be attached to the skin (being inert, low-cost, non-toxic, and flexible), several groups have recently explored the idea of developing paper-based wearable devices, specifically targeting metabolites in sweat. , In general, these sensors can not only play an essential role as non-invasive tools to monitor multiple analytes in real time − but also provide information complementary to that potentially obtained by more complex (and invasive) systems. ,− In addition, while these sensors have the potential to diversify the substrates available for wearable devices, one key challenge is to ensure that the analytical performance of these sensors is not significantly affected during use (bending, movement, etc. ) , and over multiple detection cycles.…”

Near-IR-Regulated Composite Hydrogel with Real-Time Infection Monitoring and a Combined Antibacterial Effect for Efficient Wound Management

“…It is of great significance to detect bacterial infection in situ for the timely diagnosis and treatment of wound infection. The environment of normal physiology is neutral, while that of a wound infected by bacteria is acidic. ,, Based on the slight acidic environment in an infected wound, the Au NCs@AIPH/BTB hydrogel is expected to be used for the monitoring of infected wounds due to the fact that BTB is sensitive to pH changes and is accompanied by color changes . We first studied the responsiveness of Au NCs@AIPH/BTB to the pH buffer and bacterial solution (Figure b).…”

“…14,21,42 Based on the slight acidic environment in an infected wound, the Au NCs@AIPH/ BTB hydrogel is expected to be used for the monitoring of infected wounds due to the fact that BTB is sensitive to pH changes and is accompanied by color changes. 43 We first studied the responsiveness of Au NCs@AIPH/BTB to the pH buffer and bacterial solution (Figure 3b). As shown in Figure 3c, the Au NCs@AIPH/BTB hydrogel was treated with different pH solutions for 30 min.…”

Recent advances in nanomaterial-mediated bacterial molecular action and their applications in wound therapy

“…13B). 162 More interestingly, Sun et al developed a liquid band-aid based on microneedles loaded with MOF-derived nanoparticles. As prepared liquid band-aid, which not only can enhance the penetration of the drug and facilitate microneedles to melt forming a liquid via photothermal effect but also realize nanozyme activity for antibacterial applications, could decrease skin inflammation and accelerate wound healing efficiently (Fig.…”