Recent advances in nanomaterial-mediated bacterial molecular action and their applications in wound therapy

Abstract

Nanomaterials antibacterial mechanisms and main action targets were highlighted in detail. Then, products enabled by nanomaterials used in wound therapy were elaborated, providing a theoretical foundation for broader nanomedicine applications.

The Combination of Antibiotic and Non-Antibiotic Compounds Improves Antibiotic Efficacy against Multidrug-Resistant Bacteria

“…Nanoenzymes are diverse but most of them mediate catalytic reactions (mainly redox reactions) [205]. The redox-catalyzed activity of nanoenzymes generates a free radical storm that breaks the ROS balance, thus destroying the integrity of cell membranes, degrading a wide range of molecules, including nucleic acids, proteins, polysaccharides, and lipids, and destroying the morphology of bacteria, thereby killing MDR bacteria [206][207][208][209]. Yao et al [210] reported the use of pathogen-targeting bimetallic BiPt nanozymes exhibiting dual-enzymatic activities, including peroxidase-mimic and oxidase-mimic activities, for the nanocatalytic treatment of an MDR pathogen.…”