A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation

Blacklock, Hilary; Katz, F; Michalevicz, Rita; Hazlehurst, G. R.; Davies, Lindsay C.; Prentice, HG; Hoffbrand, A. V.

doi:10.1111/j.1365-2141.1984.tb06085.x

Cited by 53 publications

(20 citation statements)

References 28 publications

(13 reference statements)

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“…The red-cell pro duction of the present patient began to recover when the isoagglutinin titre had decreased to 1:16, which is in accordance with the findings of Sniecinski et al [2], In vitro cultures of erythroid progenitors from bone marrow during total red-cell aplasia showed greatly reduced numbers or total absence of CFU-E colonies, while the numbers of BFU-E colonies were only modestly subnormal. These results are in good accordance with the report of Blacklock et al [7] who found that A and B blood group antigens are present in more than 80% of CFU-E, but in only half of BFU-E.…”

Section: Discussionsupporting

confidence: 83%

Pure Red-Cell Aplasia of Long Duration after Major ABO-Incompatible Bone Marrow Transplantation

Volin

Ruutu²

1990

Acta Haematol

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We describe a patient with an exceptionally long-lasting red-cell aplasia of 330 days following ABO-incompatible bone marrow transplantation (BMT). Before BMT, the anti-B titre was high, 1:1,024, and it was only temporarily reduced by extensive plasma exchange. The anti-B titre remained above the level of 1:64 for 270 days, and host-derived isoagglutinin could still be detected 3 years after BMT. In vitro bone marrow cultures during the red-cell aplasia showed greatly reduced numbers or total absence of CFU-E, while the number of BFU-E colonies was only moderately subnormal. Six years after BMT, bone marrow and peripheral-blood cell counts are normal.

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Section: Discussionsupporting

confidence: 83%

Pure Red-Cell Aplasia of Long Duration after Major ABO-Incompatible Bone Marrow Transplantation

Volin

Ruutu²

1990

Acta Haematol

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“…Several examples of ABO incompatibility as a risk factor after bone marrow grafts have been reported (Blacklock et al, 1984;Bar et al, 1995;Fujisawa et al, 1996;Benjamin et al, 1999). Several examples of ABO incompatibility as a risk factor after bone marrow grafts have been reported (Blacklock et al, 1984;Bar et al, 1995;Fujisawa et al, 1996;Benjamin et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Time‐course expression of polypeptides carrying blood group antigens during human erythroid differentiation

et al. 1999

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The time course expression of blood group antigens was examined by flow cytometry using a two-phase liquid culture system that supports the proliferation and maturation of human erythroid progenitors from adult peripheral blood. The progression towards erythroid differentiation was followed by the expression changes of the transferrin receptor (CD71++) and glycophorin A (GPA+). Four main categories of blood group markers were identified: (i) those characterized by an early expression like ABO (A), Kell (K:2) and Rh50 which were detected in the Epo-independent phase 1, (ii) those including GPC (Gerbich, Ge antigens) and Fy6 which were expressed in the late phase 1, (iii) GPA (MN antigens), Wrb (Band 3/GPA interaction), Rh(D, Cc/Ee) and LW which appeared during the Epo-dependent phase 2 and (iv) those like Jk3 and Lub which were expressed in late phase 2. Regarding blood group molecules exhibiting adhesive properties (LW/ICAM-4, Oka and Lu) the most significant event was a sharp decrease of Oka (neurothelin) expression with the concomitant loss of ICAMs expression during the later stage of differentiation. These studies suggest that Oka, ICAMs and LW might contribute to the adhesive interactions involved in the formation of erythroblastic islands and attachment to stroma cells and the extracellular matrix. We also noted an asynchronous expression of the proteins that compose the core of the Rh complex, since Rh50 glycoprotein was expressed earlier than Rh(D, CE) proteins.

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“…13,18 Although the in vivo mechanisms responsible for these effects have not been fully elucidated, they presumably involve interactions of antidonor isohemagglutinins with incompatible ABO antigens expressed on primitive donor erythropoietic cells. 10,[19][20][21] Low-intensity, nonmyeloablative hematopoietic stem cell transplants, or NSTs, use potent immunosuppressive conditioning regimens to promote donor engraftment sufficient for the generation of graft-versus-tumor effects against host malignant cells. 22,23 By decreasing the toxicity associated with dose-intensive conditioning, NSTs have expanded the application of SCTs to include patients with advanced age or comorbid medical conditions, as well as those with chronic and debilitating RBC-transfusion-dependent disorders.…”

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confidence: 99%

Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation

Bolan

Leitman

Griffith

et al. 2001

Blood

171

148

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Delayed donor red cell engraftment and pure red cell aplasia (PRCA) are wellrecognized complications of major ABOincompatible hematopoietic stem cell transplantation (SCT) performed by means of myeloablative conditioning. To evaluate these events following reducedintensity nonmyeloablative SCT (NST), consecutive series of patients with major ABO incompatibility undergoing either NST (fludarabine/cyclophosphamide conditioning) or myeloablative SCT (cyclophosphamide/high-dose total body irradiation) were compared. Donor red blood cell (RBC) chimerism (initial detection of donor RBCs in peripheral blood) was markedly delayed following NST versus myeloablative SCT (median, 114 versus 40 days; P < .0001) and strongly correlated with decreasing host antidonor isohemagglutinin levels. Antidonor isohemagglutinins declined to clinically insignificant levels more slowly following NST than myeloablative SCT (median, 83 versus 44 days; P ‫؍‬ .03). Donor RBC chimerism was delayed more than 100 days in 9 of 14 (64%) and PRCA occurred in 4 of 14 (29%) patients following NST, while neither event occurred in 12 patients following myeloablative SCT. Conversion to full donor myeloid chimerism following NST occurred significantly sooner in cases with, compared with cases without, PRCA (30 versus 98 days; P ‫؍‬ .008). Cyclosporine withdrawal appeared to induce graftmediated immune effects against recipient isohemagglutinin-producing cells, resulting in decreased antidonor isohemagglutinin levels and resolution of PRCA following NST. These data indicate that significantly delayed donor erythropoiesis is (1) common following major ABO-incompatible NST and (2) IntroductionThe ABO blood group system is of critical importance in transfusion medicine, but has had less dramatic impact in hematopoietic transplantation. 1-4 ABO antigens are potently immunogenic and are expressed on multiple tissues in addition to red blood cells (RBCs). 5 Human beings begin to produce isohemagglutinins against non-self-ABO antigens shortly after birth and continue to do so throughout adult life. 1 Since ABO and human leukocyte antigens (HLAs) are inherited independently, ABO incompatibility may occur in up to 20% to 40% of HLA-matched allogeneic hematopoietic stem cell transplants (SCTs). 4 Graft failure does not occur with increased frequency, and most studies indicate that the incidence of graft-versus-host disease (GVHD) is also not increased following ABO-incompatible versus ABO-identical SCT. 2,4,6 Although increased transfusion requirements and immunohematologic events occur, the overall impact of ABO incompatibility in SCT is generally considered low, provided that appropriate transfusion practices are followed. 2,4,[7][8][9][10] Major ABO incompatibility in SCTs, defined as incompatibility of donor ABO antigens with the recipient's immune system, has been associated with pure red cell aplasia (PRCA) following conventional myeloablative conditioning. [11][12][13][14][15][16][17] Proposed risks for PRCA in this setting include the use of cyclosporine ...

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A and B blood group antigen expression on mixed colony cells and erythroid precursors: relevance for human allogeneic bone marrow transplantation

Cited by 53 publications

References 28 publications

Pure Red-Cell Aplasia of Long Duration after Major ABO-Incompatible Bone Marrow Transplantation

Pure Red-Cell Aplasia of Long Duration after Major ABO-Incompatible Bone Marrow Transplantation

Time‐course expression of polypeptides carrying blood group antigens during human erythroid differentiation

Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation

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