A-90 day gavage safety assessment of Boswellia serrata in rats

Abstract

The present study deals with the evaluation and assessment of the safety/toxic potential of Boswellia serrata, a well known Ayurvedic herb used to treat disorders of digestive system, respiratory ailments and bone related diseases. A repeated dose oral (90 days) toxicity study of Boswellia serrata was carried out. For this, 10 rats of each sex were treated with the Boswellia serrata at three different doses i.e. 100, 500 and 1000 mg/kg B. wt. /day. As a control, 10 rats of each sex were treated with corn oil only which was the vehicle. Two groups consisting of five male and five female rats were kept as control recovery and high dose recovery group which were treated with the vehicle (corn oil) and the Boswellia serrata at the dose of 1000 mg/kg B. wt. Animals of control recovery and high dose recovery groups were further observed for 28 days without any treatment. From this study, it was found that the rats treated with high dose of the Boswellia serrata gained their body weight with much less rate than that of the control group. However, during the recovery period, the loss in body weight gain as observed during the study period exhibits a reversible effect on the metabolic activity and recovered. The results also indicate that Boswellia serrata is relatively safe in rat up to the dose of 500 mg/kg B.wt. as no adverse impact on health factors was observed. Thus, the No observed adverse effect level is 500 mg/kg B. wt.

The Beneficial Effect of Boswellic Acid on Bone Metabolism and Possible Mechanisms of Action in Experimental Osteoporosis

“…In the current study, the choice of AKBA was based on the various therapeutic potential described in the literature [ 10 , 12 , 13 , 14 , 15 ]. The literature also signifies that the boswellic acid is safe and is free from toxicity as no pathological changes were noticed in animals when assessed for subacute toxicity study where biochemical, hematological and histopathological parameters were determined at a dose up to 1000 mg/kg [ 38 ]. Moreover, the LD 50 of boswellic acid was reported to be >2 g/kg [ 39 ].…”

Immunomodulant feed supplement Boswellia serrata to support broiler chickens' health and dietary and technological meat quality

“…In addition, a positive impact on the nutritional and dietary value of animal-derived products has been revealed ( Al-Yasiry et al., 2017b , Kiczorowska et al., 2017 ). Comprehensive animal and human research has proved that BSR has antihyperglycemic and lipid-lowering effects ( Zutshi et al., 1986 , Singh et al., 2012 ). However, no such effect of Boswellia serrata on the lipid profile in the broiler blood was noted in the present study, which may be related to the form of the additive, that is, unpurified and unprocessed resin.…”

The In Vitro Antifungal Activity of Sudanese Medicinal Plants against Madurella mycetomatis, the Eumycetoma Major Causative Agent

“…Furthermore, although the Boswellia papyrifera extracts in overall appear to be effective and safe to administer [ 37 – 38 – 39 – 40 ], identification of the active phytoconstituents is still mandatory. This is important to decrease the probabilities of expected adverse effects and to dramatically increase the prospective extract efficacy when the isolated compounds are used as medication.…”