A 73-Year-Old Man with Interstitial Lung Disease Due to Dronedarone

Voth, Ana R. Hernández; Catalán, Javier; Mañas, Pedro D. Benavides; Martínez, Régulo José Ávila; Paolini, Carlos L. Peñalver; Rodríguez, María J. Díaz de Atauri

doi:10.1164/ajrccm.186.2.201

Cited by 11 publications

(7 citation statements)

References 3 publications

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“…Amiodarone is the most effective antiarrhythmic drug for maintaining sinus rhythm in atrial fibrillation patients. Unfortunately, droneradone is clearly less effective in maintaining sinus rhythm than amiodarone [154,155]. Beyond isolated case reports, there is little evidence that dronedarone has significant efficacy in treatment of ventricular arrhythmias [155,156].…”

Section: Is Dromedarone An Alternative Drug To Avoid Ait?mentioning

confidence: 99%

Amiodarone and thyroid physiology, pathophysiology, diagnosis and management

Trohman

Sharma

McAninch

et al. 2019

Trends in Cardiovascular Medicine

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Although amiodarone is considered the most effective antiarrhythmic agent, its use is limited by a wide variety of potential toxicities. The purpose of this review is to provide a comprehensive “bench to bedside” overview of the ways amiodarone influences thyroid function. We performed a systematic search of MEDLINE to identify peer-reviewed clinical trials, randomized controlled trials, meta-analyses, and other clinically relevant studies. The search was limited to English-language reports published between 1950 and 2017. Amiodarone was searched using the terms adverse effects, hypothyroidism, myxedema, hyperthyroidism, thyroid storm, atrial fibrillation, ventricular arrhythmia, and electrical storm. Google and Google scholar as well as bibliographies of identified articles were reviewed for additional references. We included 163 germane references in this review. Because amiodarone is one of the most frequently prescribed antiarrhythmic drugs in the United States, the mechanistic, diagnostic and therapeutic information provided is relevant for practicing clinicians in a wide range of medical specialties.

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Section: Is Dromedarone An Alternative Drug To Avoid Ait?mentioning

confidence: 99%

Amiodarone and thyroid physiology, pathophysiology, diagnosis and management

Trohman

Sharma

McAninch

et al. 2019

Trends in Cardiovascular Medicine

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“…This is supported by a study demonstrating that at equimolar concentrations dronedarone had greater alveolar macrophage toxicity than amiodarone. 4 There have been three case reports of organising pneumonia with dronedarone implicated as a contributing factor, 5,6 with a fatality in one of the three cases despite removal of the causative agent and administration of pulsed methylprednisolone in all cases. There has also been one reported case of diffuse alveolar damage attributed to dronedarone again treated with methylprednisolone with a successful outcome.…”

Section: Discussionmentioning

confidence: 99%

Organising pneumonia due to dronedarone

Thornton

Avery

Edey

et al. 2015

Journal of the Royal College of Physicians of Edinburgh

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Organising pneumonia is one of the responses of the lung to injury and can mimic bacterial pneumonia but importantly it does not respond to antibiotic therapy. We present the case of a 67-year-old male who was diagnosed with organising pneumonia secondary to dronedarone. Drug reactions are a common cause and early identification of the culprit is mandatory to prevent further morbidity and ensure a favourable outcome. On chest radiography there may be fleeting peripheral consolidation, while computed tomography can show a range of stereotyped patterns including perilobular consolidation. Bronchoscopic biopsy may not always be possible but response to steroids is often rapid following removal of the culprit drug. Dronedarone should be included in the list of possible drugs and the Pneumotox database remains a useful resource for the clinician when acute drug-related pneumotoxicity is suspected.

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“…Nonetheless, there are case reports which implicate dronedarone as causing pulmonary toxicity with its use. 81–83 Dronedarone-related pulmonary toxicity has also been described in patients with prior amiodarone use, which raises concerns of cross-reactivity. 84 The use of dronedarone is contraindicated in patients with advanced heart failure.…”

Section: Rate Controlmentioning

confidence: 99%

Atrial arrhythmias in chronic lung disease‐associated pulmonary hypertension

2020

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Atrial arrhythmias are common during episodes of acute respiratory failure in patients with chronic lung disease-associated pulmonary hypertension. Expert opinion suggests that management of atrial arrhythmias in patients with pulmonary hypertension should aim to restore sinus rhythm. This is clinically challenging in pulmonary hypertension patients with coexisting chronic lung disease, as there is controversy on the use of rhythm control agents; generally, in regard to either their pulmonary toxicity profile or the lack of evidence supporting their use. Rate control methods are largely focused on the use of beta blockers and calcium channel blockers. Concerns regarding their use involve their negative inotropic properties in cor pulmonale, the risk of bronchospasm associated with beta blockers, and the potential for ventilation/perfusion mismatching associated with calcium channel blockers. While digoxin has been associated with promising outcomes during acute right ventricular failure, there is limited evidence to suggest its routine use. Electrical cardioversion is associated with a high failure rate and it frequently requires multiple attempts. Radiofrequency catheter ablation is a more definitive approach, but concerns surrounding mechanical ventilation and sedation limit its applicability in decompensated pulmonary hypertension. Individual approaches are needed to address atrial arrhythmia management during acute episodes of respiratory failure.

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A 73-Year-Old Man with Interstitial Lung Disease Due to Dronedarone

Cited by 11 publications

References 3 publications

Amiodarone and thyroid physiology, pathophysiology, diagnosis and management

Amiodarone and thyroid physiology, pathophysiology, diagnosis and management

Organising pneumonia due to dronedarone

Atrial arrhythmias in chronic lung disease‐associated pulmonary hypertension

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