Atrial arrhythmias in chronic lung disease‐associated pulmonary hypertension

Vahdatpour, Cyrus; Luebbert, Jeffrey; Palevsky, Harold I.

doi:10.1177/2045894020910685

Cited by 13 publications

(8 citation statements)

References 108 publications

(272 reference statements)

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“…Up-to-date studies have shown that anticancer therapies may induce cardiotoxicities, such as corrected QT interval prolongation and arrhythmia [ 101 ]. Additionally, Vahdatpour et al found that atrial arrhythmia can be secondary to chronic lung disease-associated pulmonary hypertension [ 102 ]. Due to its prevalence and accompanying adverse events, investigation about arrhythmia has deepened, and we are now looking at the implications between gut microbiota and arrhythmia.…”

Section: Implications Of Gut Microbiota In Cvdsmentioning

confidence: 99%

Implication of Gut Microbiota in Cardiovascular Diseases

Zhou

Cheng

Zhu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Emerging evidence has identified the association between gut microbiota and various diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has been described in detail in CVDs, such as hypertension, atherosclerosis, myocardial infarction, heart failure, and arrhythmia. In contrast, the importance of fermentation metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and secondary bile acid (BA), has also been implicated in CVD development, prevention, treatment, and prognosis. The potential mechanisms are conventionally thought to involve immune regulation, host energy metabolism, and oxidative stress. However, numerous types of programmed cell death, including apoptosis, autophagy, pyroptosis, ferroptosis, and clockophagy, also serve as a key link in microbiome-host cross talk. In this review, we introduced and summarized the results from recent studies dealing with the relationship between gut microbiota and cardiac disorders, highlighting the role of programmed cell death. We hope to shed light on microbiota-targeted therapeutic strategies in CVD management.

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Section: Implications Of Gut Microbiota In Cvdsmentioning

confidence: 99%

Implication of Gut Microbiota in Cardiovascular Diseases

Zhou

Cheng

Zhu

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Arrhythmias are related to the severity of COVID-19 disease and could be the result of direct or indirect damage to myocardial tissue caused by multiple mechanisms ( 8 ). Pulmonary damage and its progression determine the prognosis during COVID-19 infection ( 9 ) and inflammation in pulmonary infections has been described as a trigger factor for arrhythmias ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Incidence and Predictors of Cardiac Arrhythmias in Patients With COVID-19

Mouram

Pannone

Gauthey

et al. 2022

Front. Cardiovasc. Med.

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BackgroundCoronavirus disease 2019 (COVID-19) is a systemic disease caused by severe acute respiratory syndrome coronavirus 2. Arrhythmias are frequently associated with COVID-19 and could be the result of inflammation or hypoxia. This study aimed to define the incidence of arrhythmias in patients with COVID-19 and to correlate arrhythmias with pulmonary damage assessed by computed tomography (CT).MethodsAll consecutive patients with a COVID-19 diagnosis hospitalized at Universitair Ziekenhuis Brussel, Belgium, between March 2020 and May 2020, were screened. All included patients underwent a thorax CT scan and a CT severity score, a semiquantitative scoring system of pulmonary damage, was calculated. The primary endpoint was the arrhythmia occurrence during follow-up.ResultsIn this study, 100 patients were prospectively included. At a mean follow-up of 19.6 months, 25 patients with COVID-19 (25%) experienced 26 arrhythmic episodes, including atrial fibrillation in 17 patients, inappropriate sinus tachycardia in 7 patients, atrial flutter in 1 patient, and third-degree atrioventricular block in 1 patient. No ventricular arrhythmias were documented. Patients with COVID-19 with arrhythmias showed more often need for oxygen, higher oxygen maximum flow, longer QTc at admission, and worse damage at CT severity score. In univariate logistic regression analysis, significant predictors of the primary endpoint were: the need for oxygen therapy (odds ratio [OR] 4.59, 95% CI 1.44–14.67, p = 0.01) and CT severity score of pulmonary damage (OR per 1 point increase 1.25, 95% CI 1.11–1.4, p < 0.001).ConclusionsIn a consecutive cohort of patients with COVID-19 the incidence of cardiac arrhythmias was 25%. The need for oxygen therapy and CT severity score were predictors of arrhythmia occurrence during follow-up.

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“… 24 Similarly, the abovementioned gap was reinforced in recent reviews on AF, COPD, and pulmonary hypertension. 25 , 26 …”

Section: Discussionmentioning

confidence: 99%