A 53-year-old man with herpes encephalitis showing acceleration of improvement in higher brain function after general anesthesia with sevoflurane: a case report

Togashi, Naohiko; Kaida, Kenichi; Hongo, Yu; Ogawa, Go; Ishikawa, Yukinobu; Takeda, Kazuya; Kamakura, Keiko

doi:10.5692/clinicalneurol.54.743

Cited by 1 publication

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“…Имеются только единичные публикации. Так, в работе Togashi N. et al (case report) было показано, что после об щей анестезии севофлураном у 53-летнего мужчины с герпесным энцефалитом зафиксировано ускорение улучшения высших функций мозга [49]. В обзоре, посвященном седации севофлураном у пациентов, находящихся на ИВЛ с ОРДС вследствие новой коронавирусной инфекции, отмечался противовирусный эффект ингаляционных анестетиков [50].…”

Section: противовирусный эффект ингаляционных анестетиковunclassified

Possibilities of inhalation anesthetics in blocking an excessive inflammatory response: a review

Sitkin

2022

Annals of Critical Care

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The aim of the review is to analyze the available literature data on the effect of inhalation anesthetics on inflammation. Inflammation is the most important protective and adaptive, genetically determined process that occurs in response to damage or the action of a pathogenic factor, such as bacteria, fungi and viruses. This protective reaction is based on the activation of immune cells (neutrophilic granulocytes, monocytes, macrophages) with subsequent release of reactive oxygen species (ROS), activation of the nuclear factor Kappa B (NF-kB), which causes the expression of inflammation genes and, as a result, the production of pro-inflammatory cytokines. The analysis of the results of experimental and clinical studies on this topic showed that inhalation anesthetics such as isoflurane, sevoflurane, desflurane have a powerful anti-inflammatory effect. The analysis of the results of experimental and clinical studies on this topic showed that inhalation anesthetics, and primarily sevoflurane, have a powerful anti-inflammatory effect. The anti-inflammatory effect of inhalation anesthetics is multifactorial. Experimental studies have shown that inhalation anesthetics reduce the production of reactive oxygen species. Inhalation anesthetics also block the activation of the main trigger of inflammation, namely NF-kB, and reduce the production of pro-inflammatory cytokines. Inhalation anesthetics also block the activation of the main trigger of inflammation, namely NF-kB. In addition to the anti-inflammatory effect, inhalation anesthetics are characterized by an antiviral effect. Serious clinical studies are needed to explore the possibility of using inhalational anesthetics to block the inflammatory response.

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Section: противовирусный эффект ингаляционных анестетиковunclassified

Possibilities of inhalation anesthetics in blocking an excessive inflammatory response: a review

Sitkin

2022

Annals of Critical Care

View full text Add to dashboard Cite

show abstract

A 53-year-old man with herpes encephalitis showing acceleration of improvement in higher brain function after general anesthesia with sevoflurane: a case report

Cited by 1 publication

References 4 publications

Possibilities of inhalation anesthetics in blocking an excessive inflammatory response: a review

Possibilities of inhalation anesthetics in blocking an excessive inflammatory response: a review

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