A 4D neonatal head model for diffuse optical imaging of pre-term to term infants

Brigadoi, Sabrina; Aljabar, Paul; Kuklisova‐Murgasova, Maria; Arridge, Simon; Cooper, Robert J.

doi:10.1016/j.neuroimage.2014.06.028

Cited by 60 publications

(63 citation statements)

References 55 publications

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“…Using the 10-5 positions of the DOT fiber bundles and the TOAST++ finite element photon transport modeling package, 33 a forward model was computed in an age-matched, 5-layer volumetric finite element mesh selected from the UCL 4D neonatal head model. 34 Images of changes in oxyhemoglobin concentration (HbO) and de-oxyhemoglobin concentration (HbR) were reconstructed for every 1 s of data, relative to the mean of the first 10 s of data in each HRF. Images were reconstructed in the volumetric mesh, using a multispectral linear reconstruction and zeroth-order Tikhonov regularization.…”

Section: Image Reconstructionmentioning

confidence: 99%

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

et al. 2016

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Abstract. Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.

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Section: Image Reconstructionmentioning

confidence: 99%

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

et al. 2016

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“…19 Over time, more atlases will be incorporated into the AtlasViewer distribution, including MNI152 and atlases for infants and children, and users will have access to them through the menu item "File → Change Atlas." For instance, neonatal head models for preterm and term infants have recently been published 20 and integrated into the AtlasViewer distribution. In the lower left of the GUI, controls are provided for displaying the head surface, controlling the opacity of the head, displaying the pial surface, showing the 10-20 reference points on the scalp of the atlas, and displaying the location of reference points and sources and detectors that have been digitized on a specific subject.…”

Section: Atlasviewer Interfacementioning

confidence: 99%

Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial

et al. 2015

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Abstract. Functional near-infrared spectroscopy (fNIRS) is an optical imaging method that is used to noninvasively measure cerebral hemoglobin concentration changes induced by brain activation. Using structural guidance in fNIRS research enhances interpretation of results and facilitates making comparisons between studies.AtlasViewer is an open-source software package we have developed that incorporates multiple spatial registration tools to enable structural guidance in the interpretation of fNIRS studies. We introduce the reader to the layout of the AtlasViewer graphical user interface, the folder structure, and user files required in the creation of fNIRS probes containing sources and detectors registered to desired locations on the head, evaluating probe fabrication error and intersubject probe placement variability, and different procedures for estimating measurement sensitivity to different brain regions as well as image reconstruction performance. Further, we detail how AtlasViewer provides a generic head atlas for guiding interpretation of fNIRS results, but also permits users to provide subject-specific head anatomies to interpret their results. We anticipate that AtlasViewer will be a valuable tool in improving the anatomical interpretation of fNIRS studies.

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“…The average concentration changes across channels were calculated for dataset 1 to obtain a mean haemodynamic signal to help identify the dominant features of the global haemodynamic data. Whole head image reconstruction: An age-matched voxelized tissue mask (identifying scalp, skull, cerebrospinal fluid, grey & white matter), taken from UCL's 4D neonatal head model package [15] was spatially registered to an upsampled clinical MRI image for subject 1, while an un-registered, age-matched atlas was used for subject 2. Volumetric whole head and a grey matter surface meshes were then produced with the iso2mesh package [16].…”

Section: Methodsmentioning

confidence: 99%

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

Singh

Cooper

Lee

et al. 2016

Advances in Experimental Medicine and Biology

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Neurological brain injuries such as hypoxic ischaemic encephalopathy (HIE) and associated conditions such as seizures have been associated with poor developmental outcome in neonates. Our limited knowledge of the neurological and cerebrovascular processes underlying seizures limits their diagnosis and timely treatment. Diffuse optical tomography (DOT) provides haemodynamic information in the form of changes in concentration of de/oxygenated haemoglobin, which can improve our understanding of seizures and the relationship between neural and vascular processes. Using simultaneous EEG-DOT, we observed distinct haemodynamic changes which are temporally correlated with electrographic seizures. Here, we present DOT-EEG data from two neonates clinically diagnosed as HIE. Our results highlight the wealth of mutually-informative data that can be obtained using DOT-EEG techniques to understand neurovascular coupling in HIE neonates.

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A 4D neonatal head model for diffuse optical imaging of pre-term to term infants

Cited by 60 publications

References 55 publications

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain

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