Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial

Aasted, Christopher M.; Yücel, Meryem A.; Cooper, Robert J.; Dubb, Jay; Tsuzuki, Daisuke; Becerra, Lino; Petkov, Mike P.; Borsook, David; Dan, Ippeita; Boas, David A.

doi:10.1117/1.nph.2.2.020801

Cited by 312 publications

(348 citation statements)

References 26 publications

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“…The probe was positioned per international 10–20 coordinates such that the interior medial corner of the probe was aligned with FpZ. The probe was designed to extend over Brodmann areas 10, the ventrolateral prefrontal cortex, and 46, the dorsolateral prefrontal cortex, on each hemisphere using AtlasViewer software (Aasted et al., ). Given the reduced spatial sensitivity of fNIRS compared to fMRI, we describe this region as the “LPFC”, consistent with our prior studies (Perlman et al., ; Perlman et al., ).…”

Section: Methodsmentioning

confidence: 99%

Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation

Grabell

Huppert

Fishburn

et al. 2017

Developmental Science

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Individual differences in young children’s frustration responses set the stage for myriad developmental outcomes and represent an area of intense empirical interest. Emotion regulation is hypothesized to comprise the interplay of complex behaviors, such as facial expressions, and activation of concurrent underlying neural systems. At present, however, the literature has mostly examined children’s observed emotion regulation behaviors and assumed underlying brain activation through separate investigations, resulting in theoretical gaps in our understanding of how children regulate emotion in-vivo. Our goal was to elucidate links between young children’s emotion regulation-related neural activation, facial muscular movements, and parent-rated temperamental emotion regulation. Sixty-five children (age 3–7) completed a frustration-inducing computer task while lateral prefrontal cortex (LPFC) activation and concurrent facial expressions were recorded. Negative facial expressions with eye constriction were inversely associated with both parent-rated temperamental emotion regulation and concurrent LPFC activation. Moreover, we found evidence positive expressions with eye constriction during frustration may be associated with stronger LPFC activation. Results suggest a correspondence between facial expressions and LPFC activation that may explicate how children regulate emotion in real time.

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Section: Methodsmentioning

confidence: 99%

Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation

Grabell

Huppert

Fishburn

et al. 2017

Developmental Science

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“…G). Additionally, a spatial sensitivity profile based on the Monte Carlo photon migration forward modeling was calculated using the AtlasViewer software (HOMER2 software package, http://www.nitrc.org/projects/homer2; RRID:SCR_009586) (Aasted et al., ) in order to assure that the specific probe placement enabled proper measurement of the ROIs (see Fig. A–D).…”

Section: Methodsmentioning

confidence: 99%

Different mechanosensory stimulations of the lower back elicit specific changes in hemodynamics and oxygenation in cortical sensorimotor areas—AfNIRSstudy

et al. 2016

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Background and ObjectivesThis study aimed at investigating the feasibility of functional near‐infrared spectroscopy (fNIRS) to measure changes in cerebral hemodynamics and oxygenation evoked by painful and nonpainful mechanosensory stimulation on the lower back. The main objectives were to investigate whether cortical activity can be (1) detected using functional fNIRS, and (2) if it is possible to distinguish between painful and nonpainful pressure as well as a tactile brushing stimulus based on relative changes in oxy‐ and deoxyhemoglobin ([O2Hb] and [HHb]).MethodsTwenty right‐handed subjects (33.5 ± 10.7 years; range 20–61 years; 8 women) participated in the study. Painful and nonpainful pressure stimulation was exerted with a thumb grip perpendicularly to the spinous process of the lumbar spine. Tactile stimulation was realized by a one‐finger brushing. The supplementary motor area (SMA) and primary somatosensory cortex (S1) were measured bilaterally using a multichannel continuous‐wave fNIRS imaging system.ResultsCharacteristic relative changes in [O2Hb] in the SMA and S1 after both pressure stimulations (corrected for multiple comparison) were observed. [HHb] showed only much weaker changes (uncorrected). The brushing stimulus did not reveal any significant changes in [O2Hb] or [HHb].ConclusionThe results indicate that fNIRS is sensitive enough to detect varying hemodynamic responses to different types of mechanosensory stimulation. The acquired data will serve as a foundation for further investigations in patients with chronic lower back pain. The future aim is to disentangle possible maladaptive neuroplastic changes in sensorimotor areas during painful and nonpainful lower back stimulations based on fNIRS neuroimaging.

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“…The probe arrangement was fixed in each of the caps in order to assure comparable probe placement over all subjects (see Figures 1E,F). Additionally, in order to assure appropriate placement of the probes for reaching the determined ROIs a spatial sensitivity profile of our specific probe placement was calculated based on the Monte Carlo photon migration forward modeling (Wang et al, 1995) using the AtlasViewer software (HOMER2 software package 1 ; see Aasted et al, 2015; Figure 1H). This Monte Carlo photon migration modeling was calculated for 10 million photons, revealing that our probe setup is capable of measuring in the cerebral compartment of the S1 and SMA.…”

Section: Methodsmentioning

confidence: 99%

Cortical Sensorimotor Processing of Painful Pressure in Patients with Chronic Lower Back Pain—An Optical Neuroimaging Study using fNIRS

Vrana

Meier

Hotz‐Boendermaker

et al. 2016

Front. Hum. Neurosci.

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In this study we investigated sensorimotor processing of painful pressure stimulation on the lower back of patients with chronic lower back pain (CLBP) by using functional near-infrared spectroscopy (fNIRS) to measure changes in cerebral hemodynamics and oxygenation. The main objectives were whether patients with CLBP show different relative changes in oxy- and deoxyhemoglobin ([O2Hb] and [HHb]) in the supplementary motor area (SMA) and primary somatosensory cortex (S1) compared to healthy controls (HC). Twelve patients with CLBP (32 ± 6.1 years; range: 24–44 years; nine women) and 20 HCs (33.5 ± 10.7 years; range 22–61 years; eight women) participated in the study. Painful and non-painful pressure stimulation was exerted with a thumb grip perpendicularly to the spinous process of the lumbar spine. A force sensor was attached at the spinous process in order to control pressure forces. Tactile stimulation was realized by a one-finger brushing. Hemodynamic changes in the SMA and S1 were measured bilaterally using a multi-channel continuous wave fNIRS imaging system and a multi-distant probe array. Patients with CLBP showed significant stimulus-evoked hemodynamic responses in [O2Hb] only in the right S1, while the HC exhibited significant [O2Hb] changes bilaterally in both, SMA and S1. However, the group comparisons revealed no significant different hemodynamic responses in [O2Hb] and [HHb] in the SMA and S1 after both pressure stimulations. This non-significant result might be driven by the high inter-subject variability of hemodynamic responses that has been observed within the patients group. In conclusion, we could not find different stimulus-evoked hemodynamic responses in patients with CLBP compared to HCs. This indicates that neither S1 nor the SMA show a specificity for CLBP during pressure stimulation on the lower back. However, the results point to a potential subgrouping regarding task-related cortical activity within the CLBP group; a finding worth further research.

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Anatomical guidance for functional near-infrared spectroscopy: AtlasViewer tutorial

Cited by 312 publications

References 26 publications

Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation

Using facial muscular movements to understand young children's emotion regulation and concurrent neural activation

Different mechanosensory stimulations of the lower back elicit specific changes in hemodynamics and oxygenation in cortical sensorimotor areas—AfNIRSstudy

Cortical Sensorimotor Processing of Painful Pressure in Patients with Chronic Lower Back Pain—An Optical Neuroimaging Study using fNIRS

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