A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

Kim, Kui-Jin; Lee, Ok‐Hwan; Lee, Hee-Hyun; Lee, Boo-Yong

doi:10.1016/j.tox.2009.11.007

Cited by 64 publications

(38 citation statements)

References 13 publications

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“…Fucoidan consists of L-fucose together with xylose, galactose and mannose [3][4][5]. Since the identification of fucoidan, it has been broadly studied for its numerous biological [6][7][8][9][10][11][12] and toxicological properties [13][14][15]. The biological activity of fucoidan has been reported to be closely related to molecular weight [16,17].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

2012

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Section: Introductionmentioning

confidence: 99%

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

2012

Self Cite

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“…Hayashi et al [6] reported that fucoidan reduces CCl4-induced acute and chronic liver failure with hepatic fibrosis and anti-inflammatory activity of fucoidan has been demonstrated in rats [12]. Moreover, it has been demonstrated that fucoidan is not toxic in rats at high doses [13]. Thus, fucoidan has demonstrated potential to improve human health as a supplement rather than as a drug; however, a detailed mechanism of action of fucoidan has not been verified, and its effects in humans have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer

Ikeguchi¹,

Saito²,

Miki³

et al. 2015

JCT

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In Japan, S-1 plus cisplatin has become a standard regimen for the treatment of unresectable advanced gastric cancer; however, many patients are unable to continue effective chemotherapy because of the regimen's severe side effects. Thus, control of drug toxicity is key to prolonging patient survival. Fucoidan is a major sulfated polysaccharide found in brown seaweeds and has a wide range of biological activities. In the present study, we analyzed the effect of fucoidan on suppressing the toxicity of chemotherapy drugs. Twenty-four patients with unresectable advanced gastric cancer underwent treatment with S-1 plus cisplatin and were randomly allocated into a fucoidan treatment group (n = 12) or a control group without fucoidan treatment (n = 12). The study results demonstrated that fucoidan controlled the occurrence of fatigue during chemotherapy and patients could continue chemotherapy for longer time periods by maintaining the patients' favorable nourishment status. As a result, the survival of patients with fucoidan treatment was longer than that of patients without fucoidan. Thus, fucoidan should be included as a key food supplement for patients with gastrointestinal carcinomas who are suffering from the adverse side effects of chemotherapy.

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“…Fucoidan has different activities such as anticoagulant, antithrombotic, immunomodulations, anticancer, antitumor, and antiviral actions [45]. The toxicity of fucoidan in Sprague-Dawley rats with the concentration of (1350/kg bw/day) for 4 weeks did not show any cytotoxicity with respect to ophthalmoscopy, urinalysis, hematology, and histopathology [62,63].…”

Section: Fucoidan Composites For Bone Tissue Engineeringmentioning

confidence: 99%

Marine Algae Derived Polysaccharides for Bone Tissue Regeneration

Venkatesan

Kim

2015

Marine Algae Extracts

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A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

Cited by 64 publications

References 13 publications

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice

Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer

Marine Algae Derived Polysaccharides for Bone Tissue Regeneration

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