Marine Algae Derived Polysaccharides for Bone Tissue Regeneration

Venkatesan, Jayachandran; Kim, Se‐Kwon

doi:10.1002/9783527679577.ch30

Cited by 6 publications

(4 citation statements)

References 63 publications

(69 reference statements)

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“…Generally speaking, the scaffolds have been used in two different ways to assist osteogenesis or chondrogenesis: i) in combination with growth factors to facilitate differentiation of cells via controlled release of growth factors, or ii) in the absence of any growth factors by solely relying on intermolecular interactions with important cell-membrance receptors. [55,56] This paper, reviews the most recent progress in sulfated polysaccharide-based scaffolds for skeletal tissue engineering, with particular focus on bone and cartilage tissue engineering. Specifically, three different groups of sulfated polysaccharides -sulfated GAGs, marine sulfated glycans and chemically sulfated polysaccharides, and their usage as building blocks in orthopaedic scaffolds are reviewed; since these polysaccharides present the most promising avenues in this field.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering

et al. 2019

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Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering. Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralization and strong growth factor binding and signalling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds. Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity. Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering.

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering

et al. 2019

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“…Jeong et al observed two times higher mineralization in fucoidan/nanohydroxyapatite scaffolds than in nanohydroxyapatite scaffolds, suggesting that the former matrices could be promising biomaterials for bone tissue engineering (Jeong et al 2013). Jin et al developed structures of PCL/ fucoidan using rapid prototyping technique (Gyuhyun Jin 2011), with mechanical properties and mineralization promotion superior to the ones composed by pure PCL (Gyuhyun Jin 2011;Venkatesan and Kim 2015). A recent approach to treat bone diseases involves the effect of fucoidan on human mesenchymal stem cells, observing that the fucoidan improved the stem cell behavior regarding osteogenic differentiation, namely by registering an increase in the expression of ALP, osteopontin, type I collagen, RUNX-2, and osteocalcin (Park et al 2012;Venkatesan and Kim 2015).…”

Section: Fucoidan Composites For Bone Tissue Engineeringmentioning

confidence: 99%

Marine‐origin Polysaccharides for Tissue Engineering and Regenerative Medicine

Reys

Silva

Oliveira

et al. 2020

Encyclopedia of Marine Biotechnology

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“…Alginat merupakan komponen polisakarida terbesar dalam alga perang dan dilaporkan menyumbang kepada 40% berat kering alga perang (Mohammad Latifi et al 2015;Venkatesan & Kim 2015). Menurut McHugh (1987), alginat kebanyakannya diekstrak daripada Laminaria sp., Macrocystis sp.…”

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