A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain

Razquín, Cristina; Martínez, J. Alfredo; Martínez‐González, Miguel Ángel; Mitjavila, M. T.; Estruch, Ramón; Martí, Amelia

doi:10.1038/ejcn.2009.106

Cited by 157 publications

(106 citation statements)

References 35 publications

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“…There has been no report of an inhibitory effect of oleic acid on octanoylated ghrelin production. Mediterranean diets rich in virgin olive oil are associated with decreased weight gain 37 . Since olive oil is rich in oleic acid, the suppression of octanoylated ghrelin production by oleic acid could potentially lead to a reduction in body weight gain.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Oleic Acid on Octanoylated Ghrelin Production

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Oleic Acid on Octanoylated Ghrelin Production

et al. 2015

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“…Indeed, the decrease in bifidobacteria occurring in obese mice fed with * Corresponding author: Dr J. R. Mujico, fax þ 34 915493627, email jorge.mujico@csic.es Abbreviations: CD, control diet; GM, gut microbiota; HFD, high-fat diet; HFD-S1, high-fat diet supplemented with an oleic acid-derived compound; HFD-S2, high-fat diet in combination with n-3 fatty acids; qPCR, quantitative PCR. (15,16) was counteracted through the administration of non-digestible oligosaccharides such as inulin-type fructans (17) .The Mediterranean diet has been related to lower rates of obesity (18,19) . In this diet, there is a high consumption of olive oil, which contains the MUFA oleic acid, and fish, a rich source (especially oily fish) of n-3 PUFA.…”

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confidence: 99%

Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice

et al. 2013

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Consumption of a high-fat diet (HFD), which is associated with chronic 'low-grade' systemic inflammation, alters the gut microbiota (GM). The aim of the present study was to investigate the ability of an oleic acid-derived compound (S1) and a combination of n-3 fatty acids (EPA and DHA, S2) to modulate both body weight and the GM in HFD-induced obese mice. A total of eighty mice were fed either a control diet or a HFD, non-supplemented or supplemented with S1 or S2. At week 19, faeces were collected in order to analyse the GM. Groupspecific primers for accurate quantification of several major bacterial groups from faecal samples were assayed using quantitative PCR. The HFD induced an increase in body weight, which was reduced by supplementation with S1. Furthermore, S1 supplementation markedly increased total bacterial density and restored the proportions of bacteria that were increased (i.e. clostridial cluster XIVa and Enterobacteriales) or decreased (i.e. Bifidobacterium spp.) during HFD feeding. S2 supplementation significantly increased the quantities of Firmicutes (especially the Lactobacillus group). Correlation analysis revealed that body weight correlated positively with the phylum Firmicutes and clostridial cluster XIVa, and negatively with the phylum Bacteroidetes. In conclusion, the consumption of a HFD induced changes in the faecal microbiota, which were associated with the appearance of an obese phenotype. Supplementation of the HFD with S1 counteracted HFD-induced gut dysbiosis, together with an improvement in body weight. These data support a role for certain fatty acids as interesting nutrients related to obesity prevention.Key words: Gut microbiota: Fatty acids: Obese mice: Quantitative PCR The worldwide prevalence of overweight and obesity has increased dramatically in the past decades, reaching epidemic levels (1) . It is well known that a high-fat diet (HFD) leads, especially in genetically predisposed individuals, to an accumulation of adipose tissue (2) and to the development of a cluster of metabolic and cardiovascular disorders such as type 2 diabetes, atherosclerosis, hypertension and stroke (3) .The gut microbiota (GM) has an important role in supplying nutrients and vitamins, giving colonisation resistance against pathogenic bacteria and interacting with the host immune system and intestinal epithelium (4) . The possible involvement of the host genotype, particularly as it relates to immunophenotype, has been frequently postulated as a major influence on GM composition and stability. Other variables known to broadly influence the composition of the GM include the type of delivery (vaginal or caesarean), age, the use of antibiotics and other drugs, and 'lifestyle' (such as diet, physical activity and stress) (5 -9) . The significance of the protective role of the GM has been highlighted by the profound impact seen when the GM is absent or disrupted. Germ-free mice have poorly developed mucosal architecture and rudimentary development of the mucosa-associated lymphoid tissue, b...

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“…These findings have largely been supported by a limited number of intervention trials [6][7][8][9][10].…”

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confidence: 84%

Nutritional modulation of cognitive function and mental health

Parletta

Milte

Meyer

2013

The Journal of Nutritional Biochemistry

239

187

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The important role of diet in cardiometabolic health is generally well recognised; for mental health, it is not so well understood. However, lifestyle risk factors for poor physical health are the same risk factors for mental illness, including poor diet. This is reflected by the high level of poor physical health in people with mental illness. Mediterranean, whole food diets have been associated with reduced risk for chronic disease, but very little research has investigated their mental health benefits. We provide a model for the pathways by which food components provided by a Mediterranean-style diet can facilitate healthy brain function. We then review evidence for the role of selected nutrients/food components -antioxidants, omega-3 fatty acids and B vitamins -in the brain and, hence, modulation of cognitive function and mental health. Converging evidence indicates multiple pathways by which these nutrients can assist in brain function, drawing from studies investigating them in isolation. There is very little work done on synergistic actions of nutrients and whole diets, highlighting a need for human intervention studies investigating benefits of Mediterranean-style diets for mental, as well as cardiometabolic health. ABSTRACTDietary risk factors for cardiometabolic health are generally well recognised; for mental

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A 3 years follow-up of a Mediterranean diet rich in virgin olive oil is associated with high plasma antioxidant capacity and reduced body weight gain

Cited by 157 publications

References 35 publications

Inhibitory Effect of Oleic Acid on Octanoylated Ghrelin Production

Inhibitory Effect of Oleic Acid on Octanoylated Ghrelin Production

Changes in gut microbiota due to supplemented fatty acids in diet-induced obese mice

Nutritional modulation of cognitive function and mental health

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