A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

Gurusamy, Veeraraghavan; Kanchana, Madurai Padmanabhan; Srinivasan, Lakshmi Narasimhan

doi:10.18203/2320-1770.ijrcog20164353

Cited by 2 publications

(4 citation statements)

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“…Right salpingectomy was performed and a histopathological examination of the fallopian tube revealed choriocarcinoma in both cases. This was similar to the study conducted by Veeraraghavan G et al 2 In their study, the patient presented with suspicion of ruptured ectopic pregnancy, however, histopathological examination failed to reveal molar tissue. Post-operatively, after 1 month, the patient had rising beta-hCG levels so single-agent chemotherapy was started.…”

Section: Discussionsupporting

confidence: 90%

“…10 The mean age of presentation in this study was 25.4 years which was in concordance with other studies by Jagtap SV et al and Veeraraghavan G et alwith 24.5, and 23.5 years respectively. 2,5 However, a study conducted by Koirala A et al showed a mean age of 22 years. 8 Early age of marriage may be related to early occurrence of GTD in this region.…”

Section: Discussionmentioning

confidence: 99%

“…GTD is characterized by abnormal trophoblastic proliferation inside the uterus soon following conception resulting from abnormal fertilization. The spectrum of GTD includes heterogeneous groups of interrelated histologically distinct diseases: [1][2][3]  Hydatidiform moles (complete, partial, and invasive moles)  Trophoblastic tumor-like lesions (exaggerated placental site and placental site nodule)  Gestational Trophoblastic Neoplasia /GTN (Choriocarcinoma, Placental site trophoblastic tumor, and Epithelioid trophoblastic tumor),  Abnormal (non-molar) villous lesions such as hydropic abortions, chromosomal trisomy syndromes, and placental mesenchymal dysplasia.…”

Section: Introductionmentioning

confidence: 99%

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Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

et al. 2022

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Introduction: Gestational trophoblastic diseases, because of their diverse presentation and the malignant lesions being associated with recurrence, metastasis, and mortality, early diagnosis is important with the help of ultrasonogram preoperatively, serial Beta human chorionic gonadotropin, and histopathological examination for prompt treatment and timely management of the patients. The study aimed to identify the overall prevalence and relative frequencies of Gestational trophoblastic diseases and to assess the association of different gestational trophoblastic diseases with maternal age, parity, and gestational age.Materials and Methods: This is a retrospective cross-sectional study conducted for five years from January 2016 to December 2020 in the Department of Pathology, and Department of gynecology and obstetrics of Dhulikhel Hospital, Kavre Nepal. This study included a spectrum of gestational trophoblastic diseases. All the details were obtained from the patient’s record file and register book. Results: Out of 65 cases, the most common was Hydatidiform mole with 59 (90.78%) cases. Bleeding per vagina was the most common clinical presentation. The most commonly affected age group was 21-25 years. Most of the gestational trophoblastic diseases were detected in the first trimester and primigravida.Conclusions: Any pregnant woman presenting with abnormal uterine bleeding should be evaluated for the presence of underlying Gestational trophoblastic disease. Beta-hCG is a sensitive marker, however, histopathology remains a gold standard modality for the detection of gestational trophoblastic diseases. The judicious use of ultrasonograms and appropriate clinicopathological approach helps the clinician to decide the treatment modalities, especially between evacuation and hysterectomy.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

et al. 2022

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“…Similarly, all cases of ectopic pregnancy (14) and spontaneous abortion (06) which were included in posttreatment monitoring of β-hCG value shown reduced serum level. Amongst 8 cases of MGCT, 1 patient died in follow-up, and all 5 cases who shown elevated β-hCG were monitored post-treatment for prognostic purpose and effectiveness of therapy or surgery.…”

Section: Discussionmentioning

confidence: 96%

Study of clinical significance and histopathological correlation of serum β- hCG level

Mulla

Inaniya

2017

Int J Res Med Sci

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Background: β-hCG is a marker useful in diagnosis of gestational trophoblastic disease (GTD), ectopic gestation (EG), spontaneous abortion (SA) and malignant germ cell tumors (MGCT) and it is helpful to clinician as an excellent tumor marker. It is useful to monitor treatment whether tumor is responding to treatment or the disease is progressing.Methods: β-hCG is a marker useful in diagnosis of gestational trophoblastic disease (GTD), ectopic gestation (EG), spontaneous abortion (SA) and malignant germ cell tumors (MGCT) and it is helpful to clinician as an excellent tumor marker. It is useful to monitor treatment whether tumor is responding to treatment or the disease is progressing.Results: p value is highly significant in Gestational Trophoblastic Diseases, EG and SA, as p value is < 0.005 in all these three categories. But in case of MGCT it is 0.452 which is not significant because study group was very small and one case who developed recurrence affected the value significantly. These findings suggest that β-hCG has definitive prognostic role (p value<0.005) in GTD, EG and SA.Conclusions: ELISA is rapid, sensitive, reliable and cost effective test for measurement of β-hCG. Pre-and post-therapeutic β-hCG serum levels seem to be useful in the therapy monitoring of trophoblastic gynaecological conditions i.e. GTD, EG and SA.

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A 3 year retrospective study on gestational trophoblastic disease in a government obstetrical tertiary care centre

Cited by 2 publications

References 7 publications

Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

Gestational Trophoblastic Diseases at a Tertiary care Hospital in Nepal: A Five Years Retrospective Study

Study of clinical significance and histopathological correlation of serum β- hCG level

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