A 3-Month Comparison of Efficacy and Safety of Brimonidine-Purite 0.15% and Brimonidine 0.2% in Patients with Glaucoma or Ocular Hypertension

Abstract

Brimonidine Purite 0.15% dosed BID provides equal IOP-lowering efficacy to brimonidine 0.2% BID. Patients previously controlled on brimonidine 0.2% can be successfully switched to brimonidine Purite 0.15%.

Absorption of Brimonidine 0.1% and 0.15% Ophthalmic Solutions in the Aqueous Humor of Cataract Patients

“…11 Formulation differences between 0.15% BP and 0.2% brimonidine benzalkonium chloride, and of other ophthalmologic agents, are known to affect corneal penetration of active therapeutic agents into the AH of human eyes. [12][13][14][15] Accordingly, we expected that relatively higher maximum AH concentrations would be detected in the eyes of patients undergoing routine cataract surgery given 0.1% BP versus 0.15% BP, similar to findings in rabbit eyes (data on file, Allergan study report PK-02-229; November 2002).…”

Quantitative analysis of conjunctival goblet cells after chronic application of topical drops

“…5,11,12 Brimonidine preserved with the oxidising agent Purite ® (Alphagan ® P ® ; Allergan, Irvine, CA, USA) has been shown to maintain the IOP-lowering efficacy of brimonidine preserved with BAK (Alphagan ® ; Allergan) but appears to have less harmful effect on the ocular surface. 5,13 This preservative appears to be less toxic to human cells because they contain large reserves of antioxidants that can overcome the effects of oxidising preservatives. 10 Travoprost preserved with sofZia ® a (Travatan ® Z ® ; Alcon, Fort Worth, TX, USA) is the first prostaglandin analogue not preserved with BAK.…”

Comparison of Corneal and Conjunctival Changes After Dosing of Travoprost Preserved With sofZia, Latanoprost With 0.02% Benzalkonium Chloride, and Preservative-free Artificial Tears

“…1,7,8 Brimonidine preserved with purite (Alphagan P; Allergan, Irvine, CA) has been available for several years and has been shown to be as effective in lowering intraocular pressure (IOP) as brimonidine preserved with BAK (Alphagan) while having a lower side effect profile. 1,9 Travoprost preserved with sofZia (Travatan Z; Alcon, Fort Worth, TX), is the first prostaglandin analog to be preserved with a non-BAK system. This preparation of travoprost has been proven as effective at lowering increased IOP as travoprost with BAK (Travatan; Alcon).…”