“…Silyl protecting groups occupy a significant position in synthetic organic chemistry and more so in carbohydrate chemistry. , It is well established that the silyl protecting groups that, in general, demand a huge steric space, and hence impose conformational restriction, offer better anomeric selectivities in glycosylation reactions. , However, the influence of silyl protecting groups in the chemistry of 2-deoxysugars, versatile intermediates in carbohydrate chemistry, has been under-explored because of the difficulty in synthesizing the 2-deoxy-hemiacetal precursors. The current methods for the synthesis of sugar lactols from glycals involve the use of highly acidic conditions like 4–8 M HCl or triphenylphosphine/HBr, under which some of the silyl protecting groups are usually unstable and lead to reduced yields or the decomposition of starting materials (Scheme a).…”