A 2D analysis of correlations between the parameters of the Gompertz–Makeham model (or law?) of relationships between aging, mortality, and longevity

Golubev, A. G.

doi:10.1007/s10522-019-09828-z

Cited by 18 publications

(13 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors, e.g. (Flatt 2012 ; Golubev 2009 , 2019a , b ), even associate aging with specific, such as exponential, trajectories of increases in chances of dying upon increasing time of living.…”

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

“…Attitudes to the GM law currently range from treating it as merely a convenient statistical model or tool for presenting survival data, as it is epitomized in (Stroustrup 2018 ), in which case most or the above reasoning is just empty, to believing that the law has a sound natural basis, which may be obscured by the default assumption that the age-associated decrease in viability is linear throughout the entire lifespan, which is not generally true (Golubev 2009 , 2019a , b ). The former approach does not imply any natural restrictions for changes in survival patterns and thus for the quest for a longer life.…”

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

“…This is evident from analyses of the respective published survival curves: only the pre-exponent term of the Gompertz-Makeham law ( μ 0 in Eq. 1 ) is reduced by any of the putative geroprotectors (Golubev 2019a , b ). Moreover, increases in viability, which are reflected in decreases in the pre-exponent term, are usually associated with increases in the term that reflects the rate of aging ( γ in Eq.…”

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

“…1 ). This effect, which is known as the Strehler-Mildvan correlation or the compensation effect of mortality, may be partly attributed to the mathematical artifacts of survival curve fitting (Tarkhov et al 2017 ); however, the components that are irreducible to such artifacts may be distinguished in the correlation (Golubev 2019a , b ).…”

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

See 3 more Smart Citations

An essay on the nominal vs. real definitions of aging

Golubev

2021

Biogerontology

View full text Add to dashboard Cite

In the current literature, the definitions of aging range from relying on certain sets of distinctive features at the molecular, organismal, populational and/or even evolutional levels/scales to declaring it a treatable disease and, moreover, to treating aging as a mental construct rather than a natural phenomenon. One reason of such a mess may be that it is common in the natural sciences to disregard philosophy of science where several categories of definitions are recognized, among which the nominal are less, and the so-called real ones are more appropriate in scientific contexts. E.g., water is, by its nominal definition, a liquid having certain observable features and, by its real definition, a specific combination (or a product of interaction) of hydrogen and oxygen atoms. Noteworthy, the real definition is senseless for people ignorant of atoms. Likewise, the nominal definition of aging as a set of observable features should be supplemented, if not replaced, with its real definition. The latter is suggested here to imply that aging is the product of chemical interactions between the rapidly turning-over free metabolites and the slowly turning-over metabolites incorporated in macromolecules involved in metabolic control. The phenomenon defined in this way emerged concomitantly with metabolic pathways controlled by enzymes coded for by information-storing macromolecules and is inevitable wherever such conditions coincide. Aging research, thus, is concerned with the elucidation of the pathways and mechanisms that link aging defined as above to its hallmarks and manifestations, including those comprised by its nominal definitions. Esoteric as it may seem, defining aging is important for deciding whether aging is what should be declared as the target of interventions aimed at increasing human life and health spans.

show abstract

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

Section: What the Allegedly Anti-aging Interventions Can Really Do If There Is Such Thing As Aging Consistent With The Real Definition Thmentioning

confidence: 99%

See 2 more Smart Citations

An essay on the nominal vs. real definitions of aging

Golubev

2021

Biogerontology

View full text Add to dashboard Cite

show abstract

“…There are numerous publications on the feasibility and applicability of the Gompertz law (or model) to the relationship between age and the risk of death (e.g., [14,15], which provide references to different points of view). As for Fig.…”

Section: Introductionmentioning

confidence: 99%

Theory and Practice of Aging during the COVID-19 Pandemic

Golubev

Sidorenko

2020

Adv Gerontol

View full text Add to dashboard Cite

Never before in history has population aging been a driving factor in epidemics to the same extent as with the current COVID-19 pandemic, with its dramatic shift in mortality towards older age groups. The paper presents the results of an analysis of the COVID-19-related mortality data for Spain, Italy, and Sweden, which show that within the 30- to 90-year age range, the logarithms of mortality rate depend on age linearly, and all regression lines are strictly parallel to the lines corresponding to the dependencies of the general mortality on age in accordance with the Gompertz law. In all cases, irrespective of the countries and epidemic stages, the mortality doubling times within this age range are close to 7.5 years. The probabilities of infection with the SARS-CoV-2 coronavirus, the causative agent of COVID-19, and of the development of the clinical symptoms of infection depend on age to a much lesser extent. Based on these observations, three main points are proposed for discussion: (1) Older people have become the main victims not only of SARS-CoV-2 itself but also of the measures undertaken to prevent its spread; (2) At the same time, older people are not the main force driving the spread of SARS-CoV-2, and (3) Older people can and should participate in the fight against the pandemic and in overcoming its consequences, but not through their selective isolation and other forms of discrimination. People over 65 years of age make up a considerable segment of the population and have at least as much right as other age groups to have their needs and interests be respected and observed, including the right to as high quality of life as is accessible even in extreme situations. The prospects for full control over SARS-CoV-2 are vague. This is why those who are in charge of decisions that concern people over 65 years of age should mind that, unlike the situation in the Middle Ages, the age of 65+ is the individual future of almost everyone.

show abstract

An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law

Golubev

2023

Biogerontology

View full text Add to dashboard Cite

A 2D analysis of correlations between the parameters of the Gompertz–Makeham model (or law?) of relationships between aging, mortality, and longevity

Cited by 18 publications

References 83 publications

An essay on the nominal vs. real definitions of aging

An essay on the nominal vs. real definitions of aging

Theory and Practice of Aging during the COVID-19 Pandemic

An underappreciated peculiarity of late-life human mortality kinetics assessed through the lens of a generalization of the Gompertz-Makeham law

Contact Info

Product

Resources

About